Pairing the two ingredients is safe and can make retinol easier to use. Niacinamide helps hydrate the skin, which reduces the risk of irritation caused by retinol. Niacinamide and retinol can be combined in one product or used as separate products.
Using niacinamide before retinol works well. So does combining them into one product. A 2016 study found that a product containing retinol, niacinamide, hexylresorcinol, and resveratrol improved fine lines, sallowness, wrinkling, hyperpigmentation, and skin tone.
Niacinamide and retinol can be used together with a five-minute gap between application but are likely to be just as effective if you use them at separate times of the day.
Don't Mix: Niacinamide and vitamin C. Although they're both antioxidants, vitamin C is one ingredient that's not compatible with niacinamide. "Both are very common antioxidants used in a variety of skincare products, but they should not be used one right after the other," says Dr. Marchbein.
Retinol is also an ingredient that should be left to absorb sufficiently into the skin before following up with another product. “It is important to leave a 10-20 minute wait time before applying the next product.
The best product you can use in conjunction with retinol, according to Dr. Zeichner, is a moisturizer, which can help hydrate skin and reduce the risk of irritation from retinol. “Some people even prefer to mix their retinol with a moisturizing cream to dilute it out,” he says.
After applying retinol to your skin (while it's dry) allow it to sit for 10-20 minutes. Mist your face with water or a facial spray, and then apply your hyaluronic acid. (HA serums are most effective when they're applied to damp skin.) Finally, follow your HA serum with a moisturizer right away.
Retinoids work best if you use them daily. Specifically, they should be used at night because some types are deactivated by light and air. It's important to start slowly and allow your skin time to adjust. Using too much too quickly can cause redness, dryness, and irritation.
Layering products correctly is important if you want your products to work. If you place one product on your skin, like a serum, and follow up with another product whose molecules are smaller than the first, like a toner, then the second product cannot penetrate the first layer.
Always apply Retinol products at night, as sunlight can diminish their power. If you're a prescription-strength user, use Retinol as the first layer on your skin after washing your face with a cleansing cream and before applying your anti-aging moisturizer.
Hyaluronic Acid and Niacinamide
These water-based treatments are a great pair and are made for all skin types — especially babes with dry, acne-prone skin. You'll find niacinamide, a form of vitamin B3, in my Rewind Retinol Serum. Use hyaluronic acid first, followed by my retinol for the best results.