Yes, you can layer multiple serums in your skincare routine. The best order is to apply serums from the thinnest to the thickest consistency. Start with water-based serums, such as those containing hyaluronic acid, followed by oil-based or creamier serums.
Niacinamide generally works well with most products, but it's best not to combine it with vitamin C (ascorbic acid) in the same routine as it can cause irritation. Additionally, avoid using it with strong exfoliants or retinoids in high concentrations to prevent skin sensitivity. For more, check out my Quora Profile.
A general rule of thumb is to layer 2-3 serums. This ensures skin doesn't become overwhelmed and gives each formula the space to absorb properly. However – as mentioned above, all skin is unique. Some skin concerns could benefit from up to 5 serums, if heightened moisture, protection and firming for example is needed.
To target different skin concerns, you can layer hyaluronic acid with all face serums, be it niacinamide, vitamin C, retinol, salicylic acid, alpha arbutin, azelaic acid, kojic acid, etc.
DON'T MIX: AHA/BHA and niacinamide
Niacinamide is used to treat hyperpigmentation and reduce fine lines and wrinkles, while alpha hydroxy acids (AHAs) and beta hydroxy acids (BHAs) are chemical exfoliants. To understand why niacinamide shouldn't be mixed with AHAs and BHAs, you need to consider pH.
Niacinamide works well with other skincare ingredients, including retinol and hyaluronic acid. However, some ingredients, like vitamin C, may interact negatively with niacinamide. Therefore, it's recommended to use products containing these ingredients at different times of the day or on alternate days.
Salicylic Acid is considered to be one of the most effective peeling agents. Using Salicylic Acid with Retinol or Benzoyl Peroxide can dry out the skin, causing flakiness and redness.
Niacinamide + salicylic acid is what you need in your skincare routine. Salicylic acid is best known for its deep-cleansing properties and deep-penetrating action to unclog pores and slough off dead and dry skin. The antibacterial and anti-inflammatory properties of salicylic acid help clear away pustules and papules.
For that reason, mixing peptides and glycolic acid is not recommended. Why shouldn't these acids be mixed with peptides? The reason peptides and salicylic acid as well as peptides and glycolic acid aren't efficacious ingredient combinations is because peptides are susceptible to hydrolysis when exposed to acids.
Beta Hydroxy Acids
So that salicylic acid of yours should not be mixed with your vitamin C serum. It won't be able to help you with discoloration, collagen production, or protect you from UV rays. Additionally, combining the two can cause irritation and dryness.
We recommend using no more than three serum formulations in a single regimen for optimal layering and ingredient delivery. As a summary, we suggest applying water-based solutions first, followed by anhydrous or oil formulations, and finally cream or suspension formulations.
Combining niacinamide with pure Vitamin C can destabilize both ingredients, potentially reducing their effectiveness. Best Approach: Use them at different times of the day (Vitamin C in the morning, niacinamide at night).
You might be experiencing breakouts if your skin is too sensitive to niacinamide or if you are using it in combination with other irritating products. These breakouts could be new pimples, redness, and inflammation in areas where you do not normally get acne.
Some may also have skin discoloration due to using niacinamide combined with other active ingredients that are too harsh for your skin type. Niacinamide can also cause problems when it's mixed with the following substances: Acids, including lactic acid, glycolic acid, and azelaic acid.
You can (and should) consider layering niacinamide and retinol in the same routine, especially if you have sensitive skin. Retinol is a well-known ingredient that helps reduce the appearance of fine lines, wrinkles and other signs of aging.
There are several active ingredients that can be paired together and are beneficial for your skin. However, glycolic acid and niacinamide cannot be used together at the same time. This is because mixing these two ingredients can make these acids less effective.
The answer to this question isn't a simple yes or no. Serums can be layered, but there are several factors to take into account when doing so. Some of these include ingredient compatibility, time of day, and the order in which the products are applied.
“A serum designed for daytime—which should contain antioxidants like vitamin C, green tea, or resveratrol—should be applied in the morning so it can help protect your skin throughout the day,” says board-certified dermatologist Shari Sperling, MD.
The order of application should start with cleanser and toner, followed by serums and moisturizers from lightest to thickest texture. Antioxidant serums, like vitamin C, should be applied first to protect the skin against environmental damage.