When is the best time to put tretinoin?

Author: Mortimer Bahringer  |  Last update: Monday, July 14, 2025

Apply Tretinoin at Night Apply retinoids, like tretinoin and retinol, at night. Retinoids, like tretinoin and retinol are deactivated when exposed to light so it's best to put them on right before you turn out your light to go to sleep.

Is it better to use tretinoin at night or in the morning?

Using Tretinoin Correctly

The best time to use Tretinoin is at night. This is because light can degrade Tretinoin and make it less effective. Even more importantly, your skin regenerates the most at night and so your skills will get the maximum benefits from Tretinoin when it is applied during this period.

Do you put tretinoin on before or after moisturizer?

The first key with starting to integrate tretinoin is to know when to apply it. Tretinoin should be applied to the entire face nightly — AFTER washing your face and in combination with a moisturizer. When you first start tretinoin, your goal is to apply a pea-sized amount to your entire face 2-3 nights a week.

How can I make tretinoin more effective?

How do you maximize tretinoin results? To maximize the results of tretinoin, start slowly, apply tretinoin at night on perfectly dry skin and between two layers of moisturizer, wear sunscreen with SPF 50 every morning, and combine with niacinamide or hyaluronic acid to minimize irritation.

How do you use tretinoin cream for best results?

Apply just enough medicine to very lightly cover the affected areas, and rub in gently but well. A pea-sized amount is enough to cover the whole face. You may need to use a moisturizer while you are using the lotion.

THE BEST TIME TO USE RETINOL | Dermatologist @DrDrayzday

Why do I have to wait 30 minutes to apply tretinoin?

Cleanse and wait 10-20 minutes before applying tretinoin

Never apply it on damp or wet skin because it can absorb quickly and cause skin irritation.

What not to do after applying tretinoin?

Unless your skin care specialist tells you otherwise, it is especially important to avoid using the following skin products on the same area as tretinoin: benzoyl peroxide, salicylic acid, *lactic acid, *glycolic acids, *citric acid, high strength ascorbic acid. These acids & actives will increase skin irritation.

How do you make tretinoin penetrate deeper?

Exfoliate to Amp It Up

You can further boost the efficacy of both retinol and tretinoin by exfoliating for better penetration. Treatments featuring the alpha hydroxy acid (AHA), glycolic acid, can be great for unblocking the skin's surface by removing dead cells.

What works faster than tretinoin?

Tazarotene may get you results much faster than tretinoin, especially if you have a lot of very visible sun damage on your face, and in one study tazarotene worked more effectively for photodamage, fine wrinkling, mottled hyperpigmentation, and coarse wrinkling.

Is tretinoin 3 times a week enough?

Conclusion: After 48 weeks of once-daily treatment, the continued use of tretinoin emollient cream 0.05% at a dose of three times per week maintains and, in some cases, may further enhance improvement in photodamage.

What cannot be mixed with tretinoin?

Avoid other topical retinoids, and skin care products containing retinol, with tretinoin. You may also want to avoid salicylic acid, glycolic acid, and erythromycin gel (Erthygel), as these ingredients and products can cause dryness.

Can I put tretinoin on my neck?

The skin on the neck is thinner and more sensitive, so it may not tolerate tretinoin well, causing irritation. However, if you want to address signs of ageing on your neck, you may benefit from using tretinoin there. To avoid irritation, start with a lower frequency on your neck and build up as your skin tolerates it.

Can you put tretinoin under eyes?

Yes, tretinoin can be used to treat dark circles under the eyes. It has been found to effectively reduce darkness related to pigment and improve overall skin texture. However, it's important to consult a dermatology provider before starting tretinoin treatment for dark circles.

What is the sandwich method of tretinoin?

Option one: The sandwich technique

After washing your face, apply a layer of moisturiser. Allow it to dry down for 5-10 minutes. Then, apply a pea-sized amount of tretinoin to your entire face. Allow this to dry down for 5-10 minutes.

How long does tretinoin purge last?

Skin purging typically lasts anywhere between four to six weeks which is roughly in line with how long it takes for your skin cells to naturally turnover. During this phase, it might seem like your skin is getting worse but it should settle down and improve after you've passed this period.

Should tretinoin be rubbed in?

So, when you're gently rubbing in the treatment, keep that fingernail-width buffer in mind, and you'll be good to go. Tretinoin is safe to use in the T-Zone. The T-Zone includes your forehead, nose and chin. Tretinoin is often used to treat a range of skin concerns in this area, which includes your forehead and chin.

Can I use hyaluronic acid with tretinoin?

Hyaluronic acid can also be used in combination with Clindamycin gel and Tretinoin when treating acne because it helps moisturize the skin. Hyaluronic acid can be combined with almost all other skin care ingredients because it helps to hydrate, plump, and protect the skin.

How long to let tretinoin sit before moisturizer?

The 15+ minute wait allows the skin barrier to recover and minimizes irritation. This helps reduce the risk of tretinoin induced retinoid dermatitis, a common issue for many tretinoin users.

Does tretinoin cause weight gain?

If you experience any of the following symptoms, call your doctor immediately: fever; weight gain; swelling of the arms, hands, feet, ankles, or lower legs; shortness of breath; labored breathing; wheezing; chest pain; or cough.

Can I use vitamin C with tretinoin?

Dr Malvina Cunningham: Retinoids like tretinoin and vitamin C work well together as they both promote collagen production and enhance each other's effect. Vitamin C is generally less of an irritant so these can often be applied in combination. Retinoids like tretinoin and niacinamide work well too.

Does tretinoin affect hair growth?

In conclusion, tretinoin has shown promise in promoting hair growth due to its ability to stimulate cell growth and enhance blood supply to hair follicles. While many have reported positive outcomes, it's essential to consult with a dermatologist to determine if it's the right option for you.

How to tell if tretinoin is working?

After 4-6 weeks, your skin will get used to Tretinoin and will begin to be noticeably smoother and more even. Depending on how often you use Tretinoin, you may begin to see full benefits by this point. A lot of the initial irritation will settle down and true “retinization” of your skin is in full force.

Is tretinoin gel or cream better?

Tretinoin gel is typically more potent and suitable for oily or acne-prone skin due to its quick absorption and stronger formulation. Tretinoin cream, on the other hand, is gentler and more appropriate for dry or sensitive skin, providing a more controlled release of the active ingredient.

Is tretinoin twice a week enough?

I tell my patients that it is important to begin using tretinoin gradually to allow the skin to adjust. I have my patients use it twice a week (every third night) for the first couple of months.

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