What does hyaluronic acid conflict with?

Author: Bonita Donnelly  |  Last update: Saturday, January 10, 2026

Hyaluronic Acid and Derivatives have no noted serious interactions with any other drugs.

What should not mix with hyaluronic acid?

For instance, Alpha Hydroxy Acids (AHAs), such as Lactic Acid and Glycolic Acid, and Synthetic Retinol are a pair that can easily cause irritation.

Does hyaluronic acid clash with anything?

Some active ingredients such as retinol and vitamin C can irritate the skin if used in conjunction with exfoliants such as acids, while more gentle humectants such as hyaluronic acid can make a harmonious pairing with just about everything.

Does hyaluronic acid interact with anything?

How does hyaluronic acid interact with other products? Products that combine hyaluronic acid with other medications or compounds may have some risks of side effects. It's important to tell your healthcare provider about all medications that you're taking, including supplements, vitamins, etc.

Who should avoid hyaluronic acid?

However, people who have a history of severe allergic reactions, such as anaphylaxis, should be cautious when using hyaluronic acid. Its effects during pregnancy and while breastfeeding remain unknown, so women may want to avoid taking hyaluronic acid supplements during these times.

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What is the bad side of hyaluronic acid?

The most common adverse effects associated with hyaluronic acid filler are pain, bruising, redness, itching, and swelling. These side effects are self-limited and typically last no more than seven days.

Can I use hyaluronic acid with vitamin C?

While vitamin C and hyaluronic acid can be used separately for impressive outcomes, they are also a power duo when applied in tandem. In fact, vitamin C and hyaluronic acid are often mixed - either in one serum formula, or layered in a skincare regime.

When should you not use hyaluronic acid?

If you are receiving radiation therapy, don't use hyaluronic acid on your skin. Hardening of skin and connective tissue (scleroderma): Applying hyaluronic acid to the skin might make skin ulcers worse in people who have a condition called scleroderma. If you have scleroderma, don't use hyaluronic acid on your skin.

What are the restrictions of hyaluronic acid?

You may receive between one and five injections, usually a week apart, depending on which brand of hyaluronic acid your healthcare professional uses. For at least two days after the injection, you should avoid jogging, high-impact sports or being overly active.

What happens if you use too much hyaluronic acid on your face?

That's right—using too much HA in a dry climate can make your skin drier. Imagine applying HA in your serum, moisturizer, and those enticing sheet masks you love so much—a triple threat. In a dry environment, all that HA could backfire, sucking moisture from your own skin's reserves.

What is the rule of hyaluronic acid?

The Only Rule for Hyaluronic Acid? Always Apply It on Damp Skin! It might sound surprising, but when hyaluronic acid is applied to dry skin, it can have the opposite effect, leaving your skin even more dehydrated.

Is there a problem with hyaluronic acid?

Topical Use: Most people can tolerate the topical application of hyaluronic acid products, like serums or creams. However, some individuals may encounter mild skin irritation, redness, or dryness, especially if they have sensitive skin.

Can I mix retinol with hyaluronic acid?

So, if you are looking for an answer to “Can you use retinol and hyaluronic acid together? The answer is yes. The combination of these two ingredients can help you treat multiple skin concerns and give you a more youthful, radiant complexion.

What is the best pair for hyaluronic acid?

As a pair, vitamin C and hyaluronic acid benefit the skin in numerous ways, though the duo is most often used to help combat the visible signs of aging.

What depletes hyaluronic acid?

As is the case for other natural skin-strengthening components, such as collagen and elastin, our bodily reserves of hyaluronic acid deplete with age. Other lifestyle factors, including unprotected exposure to UV rays, pollution and tobacco smoke, can speed up this natural decline.

What not to mix with peptides?

For that reason, mixing peptides and glycolic acid is not recommended. Why shouldn't these acids be mixed with peptides? The reason peptides and salicylic acid as well as peptides and glycolic acid aren't efficacious ingredient combinations is because peptides are susceptible to hydrolysis when exposed to acids.

What Cannot be paired with hyaluronic acid?

Niacinamide and Salicylic Acid: Niacinamide is a popular skincare ingredient that can help minimize pores and improve skin texture. Salicylic acid, on the other hand, is often used to treat acne. While both ingredients have their own benefits, using them together with hyaluronic acid may cause irritation or dryness.

Is hyaluronic acid hard on the liver?

10. Is Hyaluronic Acid Bad For Your Liver? In the case of patients with liver diseases, it is advised to avoid using HA as the increased levels of HA in the bloodstream can cause thrombosis. Hence, user discretion and medical supervision are advised.

What is not good with hyaluronic acid?

Things to Avoid With Hyaluronic Acid

While hyaluronic acid is a great hydrator, overusing it can lead to dehydrated skin. This happens because hyaluronic acid can only attract and retain a limited amount of moisture, and using too much can cause it to pull moisture from deeper layers of the skin.

Is there a downside to hyaluronic acid?

There are no known side effects to topical lotions and creams with hyaluronic acid, as it's already present in your body. Still, you could have an allergic reaction to a specific formulation or brand. Potential side effects of hyaluronic acid dermal filler include: Bruising.

Can I use multiple products with hyaluronic acid?

Yes. HA provides hydration, which can counteract the potential drying effects of retinoids. Since Hyaluronic Acid 2% + B5 is a water-based serum, it would be applied first and then after, you would apply retinoids, such as Retinol 1% in Squalane, as it's an anhydrous formulation.

Why is my face burning after hyaluronic acid?

Hyaluronic Acid is unlikely to cause burns. However, certain individuals may experience a stinging sensation triggered by allergies. You can avert this problem by starting with a lower concentration of Hyaluronic Acid.

Is it better to use hyaluronic acid in the morning or at night?

Incorporating a hyaluronic acid serum into your skincare regimen is easy. This versatile ingredient can be used morning and night and works well with other formulations. As always, we recommend following the 3 core stages of a skincare regimen to layer your formulations.

What should you not mix vitamin C with?

Vitamin C is effectively an acid (it's sometimes known as ascorbic acid), so layering it with AHAs and BHAs like glycolic, salicylic, and lactic acids is a big no-no.

Which serum goes first, vitamin C or hyaluronic acid?

After rinsing off your cleanser, simply massage your hyaluronic acid serum first on damp skin and allow it to soak in. Once dry, top with your vitamin C serum and finish off with a moisturizer.

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