The combination of hydroquinone with a retinoid and a corticosteroid continues to be the most extensively studied approach for treating melasma due to its enhanced tolerability and efficacy [37]. The efficacy of this combination stems from the synergistic action of its individual components.
In conclusion, Korean red ginseng powder showed good tolerability and beneficial effects in patients with melasma. The use of Korean red ginseng would be counted as a useful adjunctive therapy for patients with melasma.
Tri-Luma (fluocinolone/hydroquinone/tretinoin) - Uses, Side Effects, and More. Overview: Tri-Luma is used to treat a condition called melasma, which is where colored areas appear on the face. Tri-Luma contains three medicines.
The most commonly used treatments for melasma are skin lightening medications that are applied topically. These include medications such as hydroquinone, azelaic acid, kojic acid, niacinamide, cysteamine, rucinol, and tranexamic acid.
The combination of hydroquinone, tretinoin and a moderate topical steroid has had the best effect on melasma. Other agents that are being studied to improve melasma include: Absorbic acid (vitamin C).
Most dermatologists start Melasma treatment in India with a topical therapy. The aim of treatment of Melasma on face is to stop the melanocytes from forming any new pigments. Most commonly for the treatment of Melasma on face Hydroquinone is used.
Azelaic acid may be better than hydroquinone in reducing melasma severity (measured by MASI). However, larger studies with long-term follow-up are needed to validate these findings.
Topical proton pump inhibitors (PPIs), such as omeprazole, may also inhibit melanogenesis, and present a promising treatment for melasma. Omeprazole topically applied onto the skin of UV-irradiated human subjects elicited significant reduction of pigment levels after 3 weeks compared to untreated controls46.
Tranexamic acid (TXA), an anti-fibrinolytic drug has shown promising results in patients with melasma. Evidence from several clinical studies has surfaced on efficacy and tolerability of TXA in these patients. It can be used as monotherapy or adjuvant with other therapies.
Acupuncture is a low-injury non-pharmacological treatment. This study more comprehensively assessed the therapeutic effects of acupuncture on melasma. Acupuncture may be a safe and effective treatment option for melasma. The findings are at some risk of publication and regional bias.
Hydroquinone. HQ is the most frequently prescribed depigmenting agent worldwide and it has remained the gold standard for the treatment of melasma, particularly of the epidermal type.
Chemical peels and laser and light therapy can irritate the skin, which can make melasma worse. If you have darker skin, make sure you see a doctor who has experience using these procedures on darker skin.
Aloe vera is a fantastic melasma treatment at home, known for its soothing and healing properties. Applying fresh aloe vera gel to affected areas can help reduce pigmentation and improve overall skin health. Leave the gel on for 20-30 minutes before rinsing.
What Deficiency Causes Melasma? Studies have proved that there is a link between vitamin B12 deficiency and melasma, which means a deficiency of vitamin B12 can cause melasma on the face. Iron deficiency anemia can also lead to melasma.
Prioritizing your skincare routine and using products containing niacinamide, vitamin C and alpha hydroxy acids are essential for helping hyperpigmentation fade over time, celebrity makeup artist, Marco Antonio says. Applying a daily SPF is recommended for preventing and diminishing the appearance of melasma.
Retinol can reduce melasma by inhibiting the activity of melanocytes (the cells responsible for producing melanin). By modulating the skin's response to UV exposure and reducing tyrosinase enzyme activity, retinol helps reduce melasma pigmentation.
Your dermatologist may prescribe one or more of the following: Hydroquinone: This is a common treatment for melasma. It is applied to the skin and works to even out the skin tone. Hydroquinone is no longer available in products that you can buy without a prescription.
Can Melasma Be Treated, or Will I Have These Patches Forever? The good news is that melasma can be treated. Dermatologists have various options, including topical creams, chemical peels, and laser treatments. With the right approach, those patches can fade away.
However, by far the most potent inhibitor of human tyrosinase is 4-n-butylresorcinol with an IC(50) of 21 μmol/L. In artificial skin models, arbutin was least active with an IC(50) for inhibition of melanin production > 5000 μmol/L. Kojic acid inhibited with an IC(50) > 400 μmol/L.
Melasma can fade on its own, especially if the trigger causing it stops. Some people can have melasma for years—or even a lifetime. Sunlight worsens melasma, so avoiding sunlight and wearing an SPF 30 or higher sunscreen every day is vital to treating melasma.
Therefore, eat as many vitamins and antioxidant-rich things as possible, particularly foods high in vitamin C and E like citrus fruits, kiwis, pistachios, almonds, flaxseeds, colorful vegetables and fish (especially salmon). In addition, eat foods high in folate because a folic acid deficiency can lead to melasma.