First, choose the gentlest formula (again, retinyl palmitate or retinol), and start slowly—apply it just one night a week for one week, two nights a week for two weeks, three nights a week for three weeks, and then every other night (for sensitive skin) or every night (for “tough” skin) indefinitely.
Rouleau says the best time to use a scrub is in the morning. Overnight you've loosened up dead skin cells with your glycolic acid or retinol products, making the morning a perfect time to brush them off.
Regardless of your skin type or which product you use first, a layer of moisturizer should always be applied after retinoids.
For prescription retinols, you'll typically apply this step onto dry skin before your moisturizer—but always check with your dermatologist. You may be advised to use it after a moisturizer, which buffers the retinol and lessens risk of irritation.
Don't Mix: Retinol with vitamin C, benzoyl peroxide, and AHA/BHA acids. AHA and BHA acids are exfoliating, which can dry out skin and cause further irritation if your skincare routine already includes retinol. As for benzoyl peroxide and retinol, they cancel each other out.
The truth: You can use vitamin C with retinol and retinoids. Get them as separate products so you can tailor the concentration of each and use them at the right time of day. Although vitamin C can be used day or night, it is ideal for daytime use, while retinol and retinoids should be applied at night.
It's best to apply Vitamin C before Retinol, as Vitamin C has a lower pH than Retinol. Once your skin absorbs the Vitamin C serum, your skin will return to its regular pH levels after 30 minutes or so. (You want your skin to return to its normal pH levels so vitamin C doesn't lower the pH of retinol.)
Retinoids work best if you use them daily. Specifically, they should be used at night because some types are deactivated by light and air. It's important to start slowly and allow your skin time to adjust. Using too much too quickly can cause redness, dryness, and irritation.
“AHA, BHA, retinol, and benzoyl peroxide can be mixed with moisturizing ingredients like hyaluronic acid, ceramides, and rosehip oil to get effective results — just ensure you are not using retinol as well as AHA or BHA's during the day," says Graf.
Niacinamide and retinol can be combined in one product, which may be easier and more convenient. But they're also available as separate products. If you're using these ingredients in separate products, it's recommended to apply niacinamide first and to then follow with retinol.
Dr. Mariwalla says coating your skin with Vaseline after applying retinoids or AHA acids would increase penetration of these ingredients, potentially leading to irritation.
L'Oréal Paris RevitaLift Night Serum with Pure Retinol
Goldenberg's go-to recommendation for timing between serums and moisturizers is about one minute. This wait has the same reasoning: Sixty seconds — give or take — gives each product a moment to delve into your pores.
Should you use retinol under your eyes? Yes, definitely. While it is true that retinol – a form of vitamin A – is a powerful ingredient and the skin under your eyes is delicate, there's no reason why you should miss out on the amazing benefits of retinol.
If you're a prescription-strength user, use Retinol as the first layer on your skin after washing your face with a cleansing cream and before applying your anti-aging moisturizer. Otherwise, follow the instructions on your over-the-counter formula.
Do not use this medicine in or around the eyes or lips, or inside of the nose. Spread the medicine away from these areas when applying. If it accidentally gets on these areas, wash with water at once. Before applying tretinoin, wash the skin with a mild soap or cleanser and warm water by using the tips of your fingers.
The best product you can use in conjunction with retinol, according to Dr. Zeichner, is a moisturizer, which can help hydrate skin and reduce the risk of irritation from retinol. “Some people even prefer to mix their retinol with a moisturizing cream to dilute it out,” he says.
Hyaluronic acid is best if they're looking to moisturize dry skin, while retinol works better by encouraging better skin by boosting collagen production. They have several benefits that can work in tandem for better results, though patients need to be careful with the exact formulations they use.
Using niacinamide before retinol works well. So does combining them into one product. A 2016 study found that a product containing retinol, niacinamide, hexylresorcinol, and resveratrol improved fine lines, sallowness, wrinkling, hyperpigmentation, and skin tone.
What Are the Benefits of Combining the Two? Good news: Retinol and hyaluronic acid actually have a synergistic effect. “They can be combined so that the benefits of retinol can be achieved more easily with concomitant use of hyaluronic acid, which helps to prevent retinol irritation,” says Hartman.
Mix It Up. One tip to help your skin adjust to retinol is to mix your retinol with your face moisturizer and then apply it to your skin. This allows the retinol to be a little gentler on your skin, which is great if you have sensitive skin.
Retinol (leave to absorb for 10-20 minutes)
“It is important to leave a 10-20 minute wait time before applying the next product. Retinols are powerful antioxidants and it is important to allow it to fully absorb if you want to avoid your skin becoming sensitive,” says Dr Liakas.
Apply topical retinoids
Retinoids, which are topical vitamin A-based derivatives, may help reduce fine lines and wrinkles by increasing collagen production. If you use retinoids on your face, extend the treatment area to your neck and chest at night. Retinoid products are available by prescription or over the counter.
While Vitamin C serum predominantly protects your skin from damage, retinol serum actively heals the damage on your skin. Vitamin C serum protects the collagens while the Retinol serum helps in cell turn over thereby creating new collagens.