Does hyaluronic acid interact with anything?

Author: Emely Jerde  |  Last update: Saturday, January 10, 2026

How does hyaluronic acid interact with other products? Products that combine hyaluronic acid with other medications or compounds may have some risks of side effects. It's important to tell your healthcare provider about all medications that you're taking, including supplements, vitamins, etc.

What should be avoided with hyaluronic acid?

However, there are certain ingredients that should not be mixed with hyaluronic acid:
  • AHAs and BHAs: AHAs (alpha hydroxy acids) and BHAs (beta hydroxy acids) are chemical exfoliants that can help improve skin texture and unclog pores. ...
  • Benzoyl Peroxide: Benzoyl peroxide is a common ingredient found in acne treatments.

What does hyaluronic acid react with?

Hyaluronic Acid is a gentle ingredient that works well with almost everything! Because Hyaluronic Acid is primarily a moisturizing and soothing agent, it's actually ideal to mix this particular ingredient with other, harsher ingredients to help tone down the irritation.

What does hyaluronic acid conflict with?

Hyaluronic Acid and Derivatives have no noted serious interactions with any other drugs. Hyaluronic Acid and Derivatives have no noted severe interactions with any other drugs.

Does hyaluronic acid clash with anything?

Some active ingredients such as retinol and vitamin C can irritate the skin if used in conjunction with exfoliants such as acids, while more gentle humectants such as hyaluronic acid can make a harmonious pairing with just about everything.

Most Don't Know This About Hyaluronic Acid

Is there a downside to hyaluronic acid?

The most common adverse effects associated with hyaluronic acid filler are pain, bruising, redness, itching, and swelling. These side effects are self-limited and typically last no more than seven days.

Can I use vitamin C and hyaluronic acid together?

While vitamin C and hyaluronic acid can be used separately for impressive outcomes, they are also a power duo when applied in tandem. In fact, vitamin C and hyaluronic acid are often mixed - either in one serum formula, or layered in a skincare regime.

What drugs interact with hyaluronic acid?

Medications known to interact with hyaluronan
  • benzalkonium chloride topical.
  • cetylpyridinium topical.
  • COVID-19 mRNA (Moderna) vaccine.
  • COVID-19 mRNA (Pfizer) vaccine.
  • sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 308)
  • sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 309)
  • sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 310)

Is hyaluronic acid hard on the liver?

10. Is Hyaluronic Acid Bad For Your Liver? In the case of patients with liver diseases, it is advised to avoid using HA as the increased levels of HA in the bloodstream can cause thrombosis. Hence, user discretion and medical supervision are advised.

What is the rule of hyaluronic acid?

The Only Rule for Hyaluronic Acid? Always Apply It on Damp Skin! It might sound surprising, but when hyaluronic acid is applied to dry skin, it can have the opposite effect, leaving your skin even more dehydrated.

What are the restrictions of hyaluronic acid?

You may receive between one and five injections, usually a week apart, depending on which brand of hyaluronic acid your healthcare professional uses. For at least two days after the injection, you should avoid jogging, high-impact sports or being overly active.

What precautions should be taken after hyaluronic acid?

Temporary pain or swelling in the knee joint may occur after receiving hyaluronic acid injection. Call your doctor if the pain or swelling in the knee persists or becomes worse after receiving this medicine. Do not use this medicine with disinfectants containing quaternary ammonium salts (e.g., benzalkonium chloride).

What happens if you put too much hyaluronic acid on your face?

But like all good things, moderation is crucial. Overloading your skin with HA can lead to the paradoxical drying effect or even irritation. Less is often more. Tune into your skin's needs.

Is hyaluronic acid inflammatory?

Hyaluronic acid (HA), a large glycosaminoglycan protein found in extracellular matrix [5], has kinds of function like hyaline cartilage protection in clinical use and anti-inflammatory effect on reducing proinflammatory cytokines by acting at CD44 as its receptor [6,7].

What compliments hyaluronic acid?

What Ingredients Does Hyaluronic Acid Pair Well With?
  • Vitamin C. Yes, these two superstars can give your skin a super anti-ageing boost with Hyaluronic Acid's plumping and hydrating qualities along with Vitamin C's antioxidant and brightening properties. ...
  • Ceramides. ...
  • Retinol. ...
  • Panthenol. ...
  • AHAs & BHAs.

Who should not use hyaluronic acid?

Allergic reaction: If you are allergic to Hyaluronic Acid, you should avoid using products that contain it. Medical conditions: If you're experiencing a medical condition, such as diabetes or a bleeding disease, or if you are pregnant or nursing, you should see a doctor before taking Hyaluronic Acid.

Does hyaluronic acid affect your heart?

Hyaluronic acid binds water in the heart muscle and improves both the mechanical and electrophysiological functions of the heart. Thus, it was suggested that application of HA in the heart muscle after infarction could be a possible treatment 8.

Why do some dermatologists not like hyaluronic acid?

Kiran Mian, M.D., a board-certified dermatologist at Hudson Dermatology and Laser Surgery, “too much HA will cause it to pull moisture from deeper in the dermis into your epidermis, leaving the deeper layers of your skin dehydrated.” Given just how obsessed the skin care industry is with hyaluronic acid, you may be ...

What you Cannot mix with hyaluronic acid?

Retinol and Hyaluronic Acid

Though, using both an AHA or BHA and a retinol at the same time can be harmful to your skin.

Does hyaluronic acid affect the kidneys?

Over the past 15 years, HA has been observed to induce varying effects in kidney injury and disease that largely depend on the study model but are considerably influenced by its MW. For example, Ito et al. showed that HMW-HA bound to CD44 promotes proximal tubular cell (PTC) migration in vitro via MAPK activation [41].

What medications should you not take with collagen?

There are no well-known drug interactions and we don't yet know what the best dose of collagen is.

Is it better to use hyaluronic acid in the morning or at night?

If you have dehydrated skin, use hyaluronic acid serum both in the morning and at night. In the morning, it might help hydrate your skin and prepare it for the day ahead. At night, it might help repair and rejuvenate your skin while you sleep. Be sure to follow up with a moisturizer to lock in the hydration.

What should you not mix vitamin C with?

Vitamin C is effectively an acid (it's sometimes known as ascorbic acid), so layering it with AHAs and BHAs like glycolic, salicylic, and lactic acids is a big no-no.

Which serum goes first, vitamin C or hyaluronic acid?

After rinsing off your cleanser, simply massage your hyaluronic acid serum first on damp skin and allow it to soak in. Once dry, top with your vitamin C serum and finish off with a moisturizer.

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