BOTOX resistance is a situation in which a patient either has built up antibodies against the botulinum toxin, or happens to metabolize the BOTOX drug exceptionally quickly. As a result, for these patients BOTOX injections provide underwhelming results, a very short-lived effect, or no effect at all.
If Botox is not working for you, you may have developed Botox resistance. Immunity to Botox happens when the immune system develops antibodies that neutralize Botox proteins, rendering them ineffective. If you are immune to Botox, the drug will have partial to no paralyzing effect on your treated muscles.
“Botox resistance is a rare and not yet well-understood phenomenon that occurs when the body develops neutralizing antibodies,” explains Dr. Yang. The development of antibodies can be in response to either the active ingredient botulinum toxin or the supporting proteins in the given formula, adds Dr. Murphy.
"After receiving Botox, a patient may unconsciously attempt to re-create the facial expressions in the area where treatment has paralyzed their facial muscles, "said Dr. Becker. "What can happen is that other, nearby muscles compensate--this can have the effect of actually creating new wrinkles."
Thankfully, there are multiple alternatives to Botox you can use if aren't responding. Dysport, Xeomin, Jeuveau are the more common ones. Daxxify is a newer neuromodulator that is supposed to last a bit longer but not widely available at this point.
BOTOX resistance is a situation in which a patient either has built up antibodies against the botulinum toxin, or happens to metabolize the BOTOX drug exceptionally quickly. As a result, for these patients BOTOX injections provide underwhelming results, a very short-lived effect, or no effect at all.
Alternatives to Botox include different types of injectable neurotoxins and fillers, laser resurfacing, and cosmetic surgeries. Diet and a healthy lifestyle can also help reduce the signs of aging.
Some of the most common ones involve not getting enough Botox units for your skin issue, Botox not being injected correctly, or it could also be that some wrinkles are at a certain depth and could only be corrected so much.
The appearance of vertical lines after Botox is due to its unique utilization and weaving. The corrugator muscle is responsible for creating the inter-brow number “11” creases. Once these muscles are crippled, the brain recruits the orbicularis oculi to produce the same expression.
Your physical activity level – Proteins needs time to get into the muscles after they are injected. The facial expressions made while working out could make your muscles contract much faster and cause the Botox to wear off.
Risks aside, it's worth noting that those 65 and up might not receive the results they're looking for after receiving Botox, which is one reason the FDA lists this age as their recommended cut-off. Ultimately, the decision to receive or reject Botox at any age rests with you and your doctor.
This is probably the first question an unhappy patient will ask. Unfortunately, there is no reversal treatment for Botox. Unlike dermal fillers that can be reversed by injecting hyaluronidase, there is no procedure to “undo” Botox.
Your skin can be very sensitive after your procedure and you may find retinol irritating. It is best to avoid anything that might promote inflammation while the area heals. Avoid using anything that might promote inflammation while the area heals.
To answer this question, let's look at the 3 reasons why BOTOX will not work for you: You are not getting enough units. You are not being injected correctly. You have developed antibodies.
Our cases demonstrated the temporary appearance of new wrinkles after botulinum toxin treatment. These may be caused by hyperactivity and overcompensation of untreated muscles.
When comparing the efficacy of Dysport and Botox, much depends on personal preference. Both have proven effective in diminishing wrinkles and fine lines. Some individuals might appreciate Dysport's swifter action, while others might gravitate towards the precision Botox offers.
What to do when botox isn't working for your patient anymore. If your patient didn't respond to the toxin, in three months, I would try another brand of botulinum toxin. I would still treat it the same way, just with a different brand of toxin,” Dr Janine explains.
Botox is FDA- approved and Kardashian-approved since almost all sisters have gotten an injection at some point. The beauty of Botox is that it can also delay any new lines, which is a win for anyone concerned about aging, which is probably everyone.
Daxxify (daxibotulinumtoxinA-lanm) is the most recently approved injectable Botox alternative. It's approved to treat frown lines and neck spasms. In a clinical study, Daxxify improved the appearance of frown lines better than Botox. The biggest differentiator of Daxxify is that it can last longer than Botox.
Not everyone is a good candidate for Botox. If you are in poor general health, your skin is very thick or you have existing muscle weakness in the proposed injection site, you may not be a good candidate for Botox. Patients with sensitive skin may experience an allergic reaction at the injection site.
This is an effective, well-tolerated treatment6 requiring repeat injections every 6–9 months. However, the failure rate varies from 6% to 32% depending on the studies, and increases over time.
Other patients are simply fast metabolizers of the product. Several factors can contribute to this including genetics, exercise and stress. While genetics are out of our hands, you can try to improve stress reduction and reduce high intensity workouts to see if this affects your neurotoxin longevity.