You can combine niacinamide with all other serums and creams. You can use it with retinol, Hyaluronic acid, Vitamin C, BHAs, or AHAs. Niacinamide and retinol work well together.
If you're using these ingredients in separate products, it's recommended to apply niacinamide first and to then follow with retinol. Applying niacinamide first can help protect your skin from the effects of retinol.
How long after using niacinamide can I apply retinol? The ideal amount of time to leave in between product applications is the minimum of 30 minutes. This allows enough time to pass to help the pH levels of the skin to become rebalanced and ready for the next formulation to be applied.
Don't Mix: Niacinamide and vitamin C. Although they're both antioxidants, vitamin C is one ingredient that's not compatible with niacinamide. "Both are very common antioxidants used in a variety of skincare products, but they should not be used one right after the other," says Dr. Marchbein.
To be specific, you cannot mix retinol with AHAs (Glycolic Acid Toner, Alpha Hydroxy Acid, Lactic Acid, Mandelic Acid Treatment, Apple Cider Vinegar Acid Peel), BHAs (Beta Hydroxy Acid Serum, C-50 Blemish Night Treatment), PHA Toner.
Retinol and Benzoyl Peroxide
The ingredients can cancel the positive effects of each other out and leave skin extremely dry and irritated.
So she suggests using hyaluronic acid to compliment the vitamin-A derivative. “[It's both] hydrating and soothing, without standing in the way of the retinols ability to do its job.”
Per those acne-fighting benefits, niacinamide is often paired with salicylic acid, a beta-hydroxy acid that's a mainstay in acne products, says Dr. Frieling. Combining niacinamide's oil-reducing prowess with salicylic acid's ability to dissolve excess oil is a great way to help keep pores clear and breakouts at bay.
The reaction is likely due to another ingredient in the product. However, a high concentration of niacinamide can cause irritation. Try using a product with lower potency if this is happening. If you have a severe reaction to niacinamide or any skin care ingredient, discuss your symptoms with a dermatologist.
Niacinamide is no different. Apply your serum after cleansing (and toning, if you're a fan), and before heavier or oil-based serums, moisturiser and sunscreen. Applying oil-based serums first can impair the efficacy of your niacinamide serum, which will typically be water-based.
Niacinamide is uniquely compatible with any of the products in your skincare routine, including those that contain retinol, peptides, hyaluronic acid, AHAs, BHA, vitamin C, and all types of antioxidants.
Several blogs, and even some beauty magazine articles, state that while the two ingredients are great on their own, combining them creates a two-fold problem: One, it neutralizes the effectiveness of both ingredients, and two, it might create a substance (nicotinic acid, also known as niacin) that reddens skin.
You can absolutely use vitamin C and niacinamide together, Singh goes on to emphasize. That said, if you ever have any doubts as to whether it's safe to mix two skin care ingredients, a dermatologist can always offer advice.
Yes, you can combine niacinamide and Vitamin C to create a synergistic pairing that provides brightening, anti-aging, and protective benefits for skin.