Will the side effects of tretinoin go away?

Author: Miss Ashlee Yundt I  |  Last update: Tuesday, September 2, 2025

Some people will experience tretinoin purging when they first start using it. Tretinoin purging is when the skin gets worse before it gets better. Tretinoin speeds up the skin cell turnover process, causing some initial breakouts, drying, and peeling. These symptoms eventually go away and leave clearer skin underneath.

How long does it take for tretinoin side effects to go away?

How long does a tretinoin skin purge last? The unwanted side effects of tretinoin, in particular, the increased amount of acne breakouts usually last from two to six weeks. How to use tretinoin? What is a tretinoin purge?

Are tretinoin side effects permanent?

Some side effects of tretinoin topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

How do you fix tretinoin side effects?

Your doctor can help you choose the right skin products for you to reduce skin dryness and irritation and may include the following: For patients using tretinoin for the treatment of acne: Regular use of water-based creams or lotions helps to reduce skin irritation or dryness that may be caused by the use of tretinoin.

Does skin go back to normal after tretinoin?

Some people may notice that this side effect goes away within a few weeks of use, while others may have flaky skin for up to two months. Regardless of how long it takes to subside, tretinoin peeling is temporary and will go away once your skin gets used to the product.

Not Seeing Results with Retin-A (TRETINOIN)? Watch This Before You Quit & Avoid My Biggest Mistake

Does tretinoin reverse damage?

Regular use of this medication over time will lead to healthier appearing skin with improved texture and less wrinkles. It can replace dull-appearing skin with a pink rosy glow. In summary, if used over many months and years, tretinoin can reverse signs of excessive sun exposure.

How long until your skin gets used to tretinoin?

Initial Adaptation: The first 2-6 weeks of using Tretinoin generally involve your skin getting used to it.

What is the downside of tretinoin?

Topical tretinoin can cause your skin to become dry, red, swollen, blistered, or flaky. It may also cause your skin to itch, be painful, or feel like it is burning. Stop using topical tretinoin and call your healthcare provider if these symptoms become worse or do not go away.

How long does the tretinoin purge last?

How long does a tretinoin purge last? Results will vary from person to person. The American Academy of Dermatology recommends waiting four to six weeks for any new skin care treatment to start clearing up skin. If you are experiencing purge symptoms after six weeks, talk to your provider.

Will my skin ever adjust to tretinoin?

While you may have experienced initial sensitivity and redness during the first few weeks, after 6 weeks, your skin often becomes less sensitive to tretinoin. It is important to continue using a gentle skincare routine and sunscreen to minimize potential irritation.

Can tretinoin mess up your skin?

According to the FDA drug labeled guidelines, the most common adverse effects in topically administered tretinoin are the following: pruritus, skin pain, skin/subcutaneous irritation, erythema, and pharyngitis.

When should I give up on tretinoin?

Signs you should stop using tretinoin

“If your face is red, tender, or very parched and peeling, these are signs you're overusing your retinoid,” Dr. Ansell says—either you're applying too much, or too frequently.

What moisturizer goes well with tretinoin?

Three inexpensive moisturizers that our physicians love are Vanicream Daily Facial Lotion with Hyaluronic Acid, Neutrogena Hydroboost Gel, and The Ordinary Hyaluronic Acid Serum. All three of these are affordable, non-comedogenic,and blend well with tretinoin.

How do you know if your tretinoin is too strong?

However, with increased strength comes a greater likelihood of side effects. These include purging, redness, peeling, post inflammatory hyperpigmentation and dryness. This is why it is crucial to approach higher concentrations with caution. For this reason, Tretinoin is a prescription only medicine.

Is topical tretinoin bad for the liver?

Retinoids have been implicated in causing mild-to-moderate elevations in routine liver tests, but these elevations are usually asymptomatic and transient, resolving spontaneously even with continued therapy.

How long does tretinoin stay in your system?

The time it takes the body to metabolize (to process) medication is not the same for everyone. In healthy non-pregnant adults, it takes up to 1 day, on average, for most of the tretinoin to be gone from the body.

Is tretinoin once a week enough?

You should aim to use tretinoin every night, however, you must start slowly as your skin needs to get used to it. The first 2 weeks apply it 2 to 3 nights per week, after that try applying it every other day, and then if your skin can handle it, apply it every night.

How long do retinoid uglies last?

The retinol uglies can last anywhere from 4–8 weeks. The exact length of a retinoid purge depends very much on your skin type and sensitivity. The amount and strength of your retinoid product can also play a part. Some people experience a purge flare-up for only a few days, and others don't get it at all.

How to tell if tretinoin is working?

After 4-6 weeks, your skin will get used to Tretinoin and will begin to be noticeably smoother and more even. Depending on how often you use Tretinoin, you may begin to see full benefits by this point. A lot of the initial irritation will settle down and true “retinization” of your skin is in full force.

When do tretinoin side effects go away?

Many tretinoin side effects, like skin peeling, will go away within two to six weeks of treatment. Once the medication starts to stimulate new collagen production, it can begin to fade dark spots, treat pimples, tighten neck skin, and make the skin look younger overall.

Which is safer tretinoin or retinol?

Tretinoin is available by prescription only and is approved to treat both acne and signs of aging. Tretinoin is stronger than retinol but retinol may be gentler for sensitive skin. All topical retinoids come with the potential side effects of possible dryness, redness, and irritation.

Does tretinoin make you gain weight?

If you experience any of the following symptoms, call your doctor immediately: fever; weight gain; swelling of the arms, hands, feet, ankles, or lower legs; shortness of breath; labored breathing; wheezing; chest pain; or cough.

What is the sandwich method of tretinoin?

Option one: The sandwich technique

After washing your face, apply a layer of moisturiser. Allow it to dry down for 5-10 minutes. Then, apply a pea-sized amount of tretinoin to your entire face. Allow this to dry down for 5-10 minutes.

What are the negative long-term effects of tretinoin?

What harm does Tretinoin do to the skin?
  • It makes the skin significantly more vulnerable to UV damage.
  • It causes contact irritant and photosensitivity reactions.
  • It damages the skin's barrier.
  • It increases chronic inflammation which in turn disrupts barrier function.
  • Its use in one study has been linked to premature death.

What does tretinoin purge look like?

Skin purging is common, but doesn't necessarily happen to everyone. In fact some people don't experience it at all. For those of us who do suffer from purging, it can look like: breaking out in pustules (pimples), the appearance of flaky, peeling skin, irritation and dry patches.

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