Why you should stop tretinoin?

Author: Miss Connie Rempel Sr.  |  Last update: Tuesday, May 27, 2025

Signs you should stop using tretinoin It's normal to experience some dryness, peeling, and irritation—maybe even some purging—as you adjust to using tretinoin. But if the side effects become severe or don't go away, it might be time to hit pause and give your skin a breather.

Why you should stop taking tretinoin?

The skin will be more prone to sunburn, dryness, or irritation, especially during the first 2 or 3 weeks. However, you should not stop using this medicine unless the skin irritation becomes too severe.

Why shouldn't you use tretinoin?

Topical tretinoin can cause your skin to become dry, red, swollen, blistered, or flaky. It may also cause your skin to itch, be painful, or feel like it is burning. Stop using topical tretinoin and call your healthcare provider if these symptoms become worse or do not go away.

Is it OK to use tretinoin forever?

Dr. Mohta says that tretinoin can be used long term, even your entire life, as tretinoin is commonly used for the treatment of acne, fine lines, wrinkles, and hyperpigmentation. Dr. Mohta, also says that it may be necessary to use tretinoin for a few weeks before you can notice changes in your skin.

Does tretinoin age your skin?

Unlike over-the-counter anti-aging products, tretinoin has anti-aging ingredients that go deep beneath the outer portion of the skin to the epidermis. It boosts the production of new collagen in around six months, resulting in smoother, younger-looking skin.

6 Month Tretinoin/Retin-A Update: Before & After + My Current Skincare Routine!

When to give up on tretinoin?

Signs you should stop using tretinoin

It's normal to experience some dryness, peeling, and irritation—maybe even some purging—as you adjust to using tretinoin. But if the side effects become severe or don't go away, it might be time to hit pause and give your skin a breather.

What are the negative long-term effects of tretinoin?

What harm does Tretinoin do to the skin?
  • It makes the skin significantly more vulnerable to UV damage.
  • It causes contact irritant and photosensitivity reactions.
  • It damages the skin's barrier.
  • It increases chronic inflammation which in turn disrupts barrier function.
  • Its use in one study has been linked to premature death.

What is the best alternative to tretinoin?

Retinaldehyde is considered the closest over-the-counter alternative to tretinoin and is suitable for all skin types. It provides comparable skin renewing benefits while being less irritating, making it a suitable choice for those looking for effective yet gentle retinoid options.

Should you take a break from tretinoin?

Skipping days gives your skin a rest. Once it starts feeling better, slowly work up to using it every day (or as directed by your healthcare provider). Don't stop using your treatment altogether. As your skin adjusts, dryness and peeling will taper off.

Is tretinoin 3 times a week enough?

When you first start using tretinoin, you may start with a lower percentage that you apply just two or three times a week. After two weeks, if your skin is adjusting well to the tretinoin, you can consider increasing use to every night as tolerated.

What does tretinoin purge look like?

Skin purging is common, but doesn't necessarily happen to everyone. In fact some people don't experience it at all. For those of us who do suffer from purging, it can look like: breaking out in pustules (pimples), the appearance of flaky, peeling skin, irritation and dry patches.

Will my skin go back to normal if I stop using tretinoin?

For many, tretinoin is highly effective at treating acne, but it's still possible to experience breakouts once you stop using it.

Is topical tretinoin bad for the liver?

Retinoids have been implicated in causing mild-to-moderate elevations in routine liver tests, but these elevations are usually asymptomatic and transient, resolving spontaneously even with continued therapy.

Is it bad to use tretinoin every night?

Schwartz suggests easing into it by using tretinoin every other night at first so that your skin can adapt to it and develop a tolerance. Then, if you and your doctor decide that you might need to use it more frequently, you can apply tretinoin daily.

What moisturizer is best with tretinoin?

The La Roche-Posay Cicaplast Baume B5 Multi-Purpose Balm.

It's a shea butter and glycerin-based balm, so it's super-rich and healing-- great for night routines. Tretinoin users have reviewed this product and named it the “holy grail of moisturizers.”

Is there a better cream than tretinoin?

Another double-blind randomized study comparing tazarotene 0.1% to tretinoin 0.05% over a 24 week period also found tazarotene to be more efficacious than tretinoin for fine and coarse wrinkling, overall photodamage, and mottled hyperpigmentation.

How to wean off tretinoin?

After your skin is used to the Tretinoin, you may apply a bit more to areas with more wrinkles. 6. After your desired concentration is achieved, you may taper the Tretinoin: Apply only 3 times per week for 2 weeks, then 2 times per week for 2 weeks, then stop.

What is the highest tretinoin OTC?

The strongest dose (concentration) of tretinoin is 0.1% which is sold as a cream under the brand name of Retin-A and is sold as a gel under the brand name Retin-A micro.

Is it OK to use tretinoin for years?

Conclusion: Long-term treatment with tretinoin emollient cream 0.05% is safe and effective in subjects with moderate to severe facial photodamage.

Is tretinoin bad for the heart?

Treatment with this drug may lead to higher cholesterol and triglycerides. The effect of these changes on heart health is not known. Talk with the doctor.

Does tretinoin thicken or thin skin?

Topical tretinoin stimulates epidermal proliferation and differentiation by upregulating heparin binding epidermal growth factor (HB-EGF), which causes increased exfoliation and thickening of the epidermis.

What are the tretinoin uglies?

A tretinoin purge, also referred to as “tretinoin uglies” is a common skin reaction that occurs when a patient uses tretinoin (Retin-A or Tretin-X) for the first time.

What is the sandwich method for tretinoin?

Option one: The sandwich technique

After washing your face, apply a layer of moisturiser. Allow it to dry down for 5-10 minutes. Then, apply a pea-sized amount of tretinoin to your entire face. Allow this to dry down for 5-10 minutes.

How long should I stay on tretinoin?

Tretinoin helps remove dead skin cells, allowing new cells to rise to the surface more efficiently. This stimulates collagen production and helps to reverse the effects of long-term sun exposure1. Tretinoin should be used for at least 6 months for maximum effect.

Previous article
What is the perfect lip size ratio?
Next article
What not to do after sunbed?