Why is my Botox not working after 2 weeks?

Author: Earnestine McLaughlin  |  Last update: Monday, June 30, 2025

Botulinum toxin resistance may develop due to frequent exposure or high doses over time. Dr Janine explains, ”Botox can stop working due to recurrent top-ups after the 2-4 week review window.

Is it normal for Botox to not work after 2 weeks?

It is normal. However, if after 14 days you still see no results, you should contact your doctor. Usually, a follow-up appointment is already scheduled to address any lack of effect. Are There Any Long-term Effects of Botox?

Is it normal to not see results from Botox after 10 days?

Answer: Botox Results Typically, Botox injections take between 7-10 days to see the full result. If you still don't see a result after 10 days, you should follow up with your doctor.

What would cause Botox not to work?

So what could be the reasons behind Botox not working on forehead wrinkles? Some of the most common ones involve not getting enough Botox units for your skin issue, Botox not being injected correctly, or it could also be that some wrinkles are at a certain depth and could only be corrected so much.

Why does my Botox only last a few weeks?

There are various reasons why Dysport or Botox might last a shorter period of time in some individuals. These reasons include injection technique issues, storing the product for a long period of time, improper dilution of the product, antibodies, individual metabolism, and inadequate units.

Is Your Botox Not Working? This May Be Why

What causes Botox to wear off faster?

For those with a faster metabolism, the effects of Botox may wear off more quickly as their bodies metabolize the toxin at an accelerated rate. The process by which the body breaks down and eliminates Botox involves digestive proteins in nerve endings, which can vary between individuals and thus affect Botox longevity.

How to make Botox more effective?

How Can You Ensure You Get the Best Results With Botox Treatments?
  1. Avoid Touching or Rubbing the Treated Areas. ...
  2. Stay Upright and Avoid Strenuous Exercise. ...
  3. Avoid Alcohol and Blood-Thinning Medications. ...
  4. Be Patient and Allow Time for Results. ...
  5. Follow Any Specific Instructions. ...
  6. Avoid Excessive Heat or Cold. ...
  7. Stay Hydrated.

What can ruin Botox?

7 Things Not to Do After Botox
  • Rubbing Your Face. ...
  • Sun and Heat Exposure. ...
  • Intense Exercise. ...
  • Taking Blood Thinners. ...
  • Alcohol Consumption. ...
  • Washing Your Face With Soap. ...
  • Applying Topical Products.

Why are my 11 lines still there after Botox?

For instance, if your forehead furrows smoothed out, but your “11” lines are still visible, you may need a touch-up with more units of Botox. Or, we may recommend fillers to resolve the problem. Your two-week evaluation is part of your initial Botox treatment.

What to use if Botox doesn't work?

What to do when botox isn't working for your patient anymore. If your patient didn't respond to the toxin, in three months, I would try another brand of botulinum toxin. I would still treat it the same way, just with a different brand of toxin,” Dr Janine explains.

Is 40 units of Botox a lot?

Usually, an average Botox treatment is in the range of 40-50 units, meaning the average cost for a Botox treatment is between $400 and $600. Forehead injections (20 units) and eyebrow lines (up to 40 units), for example, would be approximately $600 for the full treatment.

Why do you need a Botox top up after 2 weeks?

FIRST RULE OF BOTOX TOP-UPS. The first rule here is to ensure you are not offering a botox top-up before the two week mark. As we know, the botulinum toxin is still taking effect during this time so we need to allow enough time for the administered dose to reach its potential.

What is the best alternative to Botox?

Below are 10 alternatives to BOTOX® that might help if you're seeking smoother or firmer skin on your face.
  • Cosmetic Acupuncture. ...
  • Microneedling. ...
  • Chemical Peels. ...
  • Laser Therapy. ...
  • Cryotherapy. ...
  • Facial Creams. ...
  • Neuropeptides. ...
  • Face Patches.

How do you know if Botox hasn't worked?

What Happens When Botox Doesn't Work. If, after four weeks, you notice little to no change in your ability to move the treated muscles, there is a possibility you have developed Botox resistance. The first thing you should do in this instance is give your Botox provider a call and let them know what's going on.

How do I know if I need a Botox top up?

First, it's key to wait 2 weeks after your initial Botox appointment to see how your results develop; if you are still able to see some movement and form the facial expressions that create the targeted dynamic wrinkles in your face, then you may need a touch-up, adding a few additional units to the same sites.

What causes resistance to Botox?

Botox resistance or Botox immunity is when a patient's immune system develops antibodies that neutralize the active molecule in the injectable – botulinum toxin type A. Upon injection, the antibodies stick to the molecule before it has a chance to act on the nerve and block nerve signals to the target muscle.

When does Botox look the best?

By the 14th day, the full results of your Botox treatment should be evident, showcasing a smoother and more refreshed appearance. It is an ideal time to attend your follow-up appointment to ensure everything has gone smoothly and to discuss any adjustments that may enhance your results.

Why is Botox not working on my forehead?

If you did not receive the right amount of Botox unit needed for your forehead wrinkles, it's highly possible that the treatment may not show your desired results. To avoid this mistake, you should always have an initial consultation with your provider to determine the exact amount of Botox injections you'll need.

How many units of Botox is typical for 11 lines?

Eleven lines can unintentionally leave you looking sad or angry, but BOTOX can help you look smoother and more refreshed. Most patients require 10 to 30 units of BOTOX to treat their 11 lines.

What cancels out Botox?

This is probably the first question an unhappy patient will ask. Unfortunately, there is no reversal treatment for Botox. Unlike dermal fillers that can be reversed by injecting hyaluronidase, there is no procedure to “undo” Botox.

Do any drugs interfere with Botox?

If you are taking any other medicine, please inform your doctor before getting a Botox injection. Interactions with antibiotics, blood thinners, muscle relaxants, sleeping pills, cold or allergy medicine, bronchodilators, and many other prescriptions and over the counter drugs have been reported.

Does retinol break down Botox?

For a minimum of 3 days post-treatment, avoid using anything perceived as 'active' skincare. This includes products which contain Retinol, Vitamin C, Hydroxy Acids or Beta Hydroxy Acid. For 24 hours, avoid sunbathing, intentional direct sunlight and tanning beds. Stay away from swimming for 24 hours post-treatment.

Does drinking lots of water help Botox?

Drink Plenty of Water

Even acute dehydration wreaks havoc on your overall health and is terrible for your skin. To get the most out of your Botox treatments, drink between half a gallon and a full gallon of water per day.

What vitamin helps Botox last longer?

Take a Zinc Supplement

In a study from the Journal of Drugs in Dermatology, researchers found that people who received Botox and then took a 50-milligram zinc supplement saw a significantly longer duration in their results.

Why is my Botox not lasting?

Metabolism: Your metabolism affects how quickly your body breaks down Botox. Individuals with faster metabolisms may find that the effects wear off more quickly. Muscle Activity: The more you use the treated muscles, the faster the Botox may wear off.

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