Who cannot use niacinamide?

Author: Kaitlyn Volkman  |  Last update: Wednesday, October 1, 2025

Gallbladder disease: Niacinamide might make gallbladder disease worse. Kidney dialysis: Taking niacinamide seems to increase the risk of low platelet levels in people with kidney failure who are on dialysis. Stomach or intestinal ulcers: Niacinamide might make ulcers worse.

Does niacinamide interact with any medications?

If you take certain drugs to lower blood fats (bile acid-binding resins such as cholestyramine or colestipol), take niacinamide at least 4 to 6 hours before or after taking these medications. These products may bind with niacinamide, preventing its full absorption.

Can everyone use niacinamide?

Yes, niacinamide is safe and beneficial for people of all ages, including 19-year-olds. It helps with acne, improves skin tone, and strengthens the skin barrier. It's gentle and works well in combination with other ingredients, making it an excellent choice for maintaining healthy skin.

Why i can't use niacinamide?

Niacinamide is a goodie and if your skin likes it, use it! That said, it can cause irritation and/or texture/breakouts for some people, especially so at high percentages (its most effective at 2-5%, anything above 5% only causes higher chance and higher amount of irritation with no added effextiveness).

What should you never mix niacinamide with?

DON'T MIX: AHA/BHA and niacinamide

Niacinamide is used to treat hyperpigmentation and reduce fine lines and wrinkles, while alpha hydroxy acids (AHAs) and beta hydroxy acids (BHAs) are chemical exfoliants. To understand why niacinamide shouldn't be mixed with AHAs and BHAs, you need to consider pH.

BEST & WORST NIACINAMIDE NYKAA| Dr Vanita Rattan

Are some people sensitive to niacinamide?

While rare, some people may experience an allergic reaction to niacinamide, known as contact dermatitis. Symptoms can include redness, itching, swelling, and a burning sensation. Those experiencing these symptoms should discontinue use and seek medical advice.

How do you know if niacinamide is not for you?

People of all skin types can use niacinamide—from dry to oily or combination skin. To be sure it's safe, though, always apply niacinamide products to a test area of skin and observe for reactions. If you experience redness, itchiness, or further irritation, stop its use and consult a professional.

Why is my skin getting darker after using niacinamide serum?

Some may also have skin discoloration due to using niacinamide combined with other active ingredients that are too harsh for your skin type. Niacinamide can also cause problems when it's mixed with the following substances: Acids, including lactic acid, glycolic acid, and azelaic acid.

Do dermatologists recommend niacinamide?

“I typically recommend the topical form of this ingredient for three main skin concerns, including anti-aging, uneven skin tone, and oiliness and large pores.”

What does niacinamide conflict with?

Ordinary niacinamide combined with an acid can cause a bad chemical reaction of redness and flushing. You'll want to leave at least 30 minutes between products or keep your niacinamide in the morning and your acids at night.

Who should not take nicotinamide?

People with a history of liver disease, kidney disease, or stomach ulcers should not take niacin supplements. Those with diabetes or gallbladder disease should do so only under the close supervision of their doctors. Stop taking niacin or niacinamide at least 2 weeks before a scheduled surgery.

Does niacinamide remove dark spots?

Niacinamide, a vitamin B3 derivative, is effective at reducing hyperpigmentation, capable of lightening dark spots significantly after several weeks' usage. Importantly, niacinamide is NOT a skin bleaching agent.

What are the disadvantages of niacinamide on face?

What are the side effects of Niacinamide? Topical application is completely safe and may not cause any skin problems for a healthy person. People with sensitive skin may face mild redness, itching, or a burning sensation. Stomach upset.

What are the contraindications for niacinamide?

There are 4 disease interactions with niacinamide which include:
  • liver disease/hepatotoxicity.
  • peptic ulcer disease.
  • hyperglycemia.
  • hyperuricemia.

Which hormone causes skin darkening?

Estrogen and progesterone are two of the major factors responsible for catamenial hyperpigmentation of the skin.

Is 10% niacinamide too strong?

For general skin tone correction, a niacinamide concentration between 4-5% is often effective and well-tolerated by most individuals. For those looking to tackle more pronounced hyperpigmentation, a higher concentration of 10% may be beneficial, though it's important to monitor the skin for any signs of irritation.

How long does it take for skin to adjust to niacinamide?

How long does niacinamide take to work? Generally, you should start to see results after 2-4 weeks of twice daily usage (depending on the severity of your skin concerns and the concentration of your niacinamide formula). Ongoing use is required for continued improvement and maintained results.

Who should avoid niacinamide?

Gallbladder disease: Niacinamide might make gallbladder disease worse. Kidney dialysis: Taking niacinamide seems to increase the risk of low platelet levels in people with kidney failure who are on dialysis. Stomach or intestinal ulcers: Niacinamide might make ulcers worse.

What should you not mix with niacinamide?

Niacinamide might not reach its full effectiveness when mixed with AHAs or BHAs. Moreover, this combination could be overwhelming for your skin, leading to adverse effects such as skin peeling, redness, and itchiness.

What happens to your skin when you start using niacinamide?

Niacinamide also helps prevent the transfer of pigment within the skin, meaning that you'll have fewer brown spots. Its anti-inflammatory properties make it helpful for treating skin inflammation and managing related symptoms, such as redness and red patches.

What reacts badly with niacinamide?

Though all skin types can benefit from niacinamide, Dr. Li warns that "combining niacinamide with vitamin C, also known as ascorbic acid, makes niacin, and may cause skin irritation and transient flushing." For this reason, Dr.

What is a good alternative to niacinamide?

Fortunately, there are natural alternatives to niacinamide that can provide similar benefits. One of the most powerful is aloe vera. Aloe vera is a succulent plant that has been used for centuries for its medicinal properties. It's also a popular ingredient in natural skincare products.

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