The strongest retinoids on the market are tazarotene 0.1% - either the cream of the gel. In most cases tazarotene 0.1% gel is the strongest- especially when it is used before a moisturizer.
Our top choice, CeraVe Resurfacing Retinol, comes recommended by dermatologists thanks to its blend of powerful retinol and skin-soothing ingredients. We also liked Neutrogena's Rapid Wrinkle Repair Retinol Pro+, a high-strength retinol with a smooth, fast-absorbing application.
1. SkinCeuticals Retinol 1.0 Maximum Strength Refining Night Cream. Formulated with the highest concentration of 1.0% pure retinol and botanical extracts, this cream is enhanced with the latest stabilization and delivery technologies to preserve retinol potency and ensure maximum efficacy and stability.
Peter Thomas Roth Fusion PM Night Serum is our top choice due to its high concentration of encapsulated retinol and skin-loving antioxidants and hydration benefits. For a more affordable choice, consider The Ordinary Retinol 1% in Squalane, where retinol is suspended in squalane and blended with jojoba oil.
The Ordinary's Granactive Retinoid* 2% Emulsion ($9.80) is a retinoid active, part of the family of age-defiers that helps reduce wrinkles. While retinoids (a.k.a. a vitamin A derivatives) often get a bad rep for being irritating, The Ordinary's formula is designed to make the serum gentle while still being effective.
Tretinoin is considered to be the most widely used prescription retinoid treatment for wrinkles. It comes in the form of a gel. During use, you must wear sunscreen daily to protect your skin from sunburn and photoaging.
Those with stubborn skin concerns, like deep wrinkles and pronounced uneven skin tone may want to consider a high percentage retinol cream, serum or treatment. But what percentage of retinol is effective? Look for formulations with a percentage between 0.3% and 1%, with retinol 1% being the strongest option.
The good news is that it is never too late to start incorporating retinol into your skin care routine. People in the 60s and beyond have begun using retinol and still experienced results.
Because retinoids help your skin make more collagen, they soften wrinkles and fine lines. They also stimulate new blood vessels, which can give your skin a rosy color. Retinoids also help fade age spots and smooth rough patches. Tretinoin (Retin-A) is a popular prescription choice for aging skin.
Retinol can penetrate deep into your skin's layers to activate collagen and elastin, which give your skin structure and support to prevent wrinkles. You can apply products that contain retinoids at home directly onto your skin as you would a lotion or a moisturizer.
While vitamin C is most notable for helping to brighten and improve hyperpigmentation, retinol is typically considered best-in-class for wrinkles and fine lines. And if you really want to give your skin a one-two punch to get noticeably healthier, you can certainly try incorporating both into your routine.
“Studies suggest you need to use at least 0.25% retinol or 0.025% tretinoin to be effective, so I recommend using a product that specifies the percentage.”
As Dr. King mentions, peptides make a great retinol alternative. Versions such as copper peptides, palmitoyl tetrapeptide-7, and hexapeptides increase skin elasticity and firmness, stimulate cell regeneration, and diminish creasing, respectively, making them extremely versatile when it comes to antiaging.
Retinol is best applied at night since it can increase your skin's sensitivity to the sun. When you do go outside, be sure to use sunscreen to protect your face. It's worth noting that you don't need to use retinol on a daily basis for it to effectively treat your acne. Even two to three times per week might be enough.
Retin-A is the brand name of a drug called tretinoin, which was the very first retinoid developed for skin use. Retin-A requires a prescription from a dermatologist.
"If you have dry, irritated skin that is lacking in moisture, choosing a product with hyaluronic acid would be my recommendation," Hartman says. "Anyone with acne-prone skin, or someone who is looking to even out tone and fine lines and wrinkles would benefit from using retinol."
Best retinol for beginners
A good first retinol to try is this Neutrogena cream recommended by dermatologist Dr. Britt Craiglow.
First, the answer is yes, retinol can make wrinkles worse, especially when you first start using it. What is happening is a drying effect, and one can get epidermal sliding from separation from the dermis.