What's better, hyaluronic acid or niacinamide?

Author: Chad Osinski  |  Last update: Sunday, December 7, 2025

For those struggling with acne, inflammation, or excess oil production, niacinamide may be the better option. On the other hand, if your primary concern is dryness, dehydration, or aging skin, hyaluronic acid could be the way to go.

Is it better to use hyaluronic acid or niacinamide?

The critical difference between the two is that hyaluronic acid is helpful mainly in hydrating the skin. In contrast, niacinamide helps remove aging signs, treat acne, and provide an even skin tone. So, you can try them individually or even together as per your individual needs.

Is niacinamide drying or hydrating?

When used as part of a daily skincare routine, niacinamide may help calm the skin, reduce transepidermal water loss (TEWL), and increase hydration in the skin's uppermost layer. This makes niacinamide a beneficial skincare ingredient for those looking to promote hydrated, smooth, and even-toned skin.

Can I use the ordinary hyaluronic acid and niacinamide together?

Yes, you can. Our Hyaluronic Acid 2% + B5 hydrates the skin, while Niacinamide 10% + Zinc 1% can help with pore appearance and uneven tone. Since both serums are water-based, they can be applied in either order, however, we recommend addressing your primary concern first and then apply the other.

Do you really need niacinamide?

Niacinamide is a form of vitamin B3 or niacin, an essential nutrient that provides many health benefits to your skin, kidneys, heart, nerves, gut, brain, and other body organs.

4 Niacinamide Combinations You Need To Know

Is it OK to use niacinamide everyday?

How often should you use niacinamide? For optimal benefits, we recommend using niacinamide either daily or twice a day. Whether you apply niacinamide once or twice a day will depend on your skin type, skin concerns and which other ingredients are contained within your morning and night routines.

What are the only four skincare ingredients that have been proven to work?

These are retinoids, vitamin C, niacinamide and alpha hydroxy acids (AHAs). Whereas ingredients such as hyaluronic acid temporarily plump and smooth the skin, some of the big 4 may have longer-term health benefits.

What should you not mix with niacinamide?

Niacinamide and AHAs / BHAs

Similar to retinol, niacinamide should not be used with acidic skincare ingredients like alpha hydroxy acids and beta hydroxy acids. Ordinary niacinamide combined with an acid can cause a bad chemical reaction of redness and flushing.

Should I use niacinamide in the morning or night?

4. When should I apply niacinamide? Niacinamide can also be used morning and/or night, but as it's an antioxidant and can help to control oil and treat breakouts (invisibly!), it is well-suited to a morning routine (just avoid layering it with vitamin C as the two can make each other unstable).

In what order should I use ordinary products?

You'll want to apply water-based treatments first, followed by anhydrous (water-free) solutions or oil formulations, followed by creams or suspensions. This means that you would apply a water-based serum such as Amino Acids + B5 before an anhydrous serum or oil such as Retinol 0.2% in Squalane..

Is 10% niacinamide too much?

For general skin tone correction, a niacinamide concentration between 4-5% is often effective and well-tolerated by most individuals. For those looking to tackle more pronounced hyperpigmentation, a higher concentration of 10% may be beneficial, though it's important to monitor the skin for any signs of irritation.

What is more hydrating than hyaluronic acid?

Not as well-known as Hyaluronic Acid, Polyglutamic Acid, commonly abbreviated as “PGA,” is believed to have 4x greater moisture retaining benefits than HA. If you have dull, dry, or dehydrated skin, you should consider incorporating Polyglutamic Acid Serum into your skincare recipe.

How long to wait between hyaluronic acid and niacinamide?

Hyaluronic acid serums are usually lightweight and absorb quickly, so you don't need to wait longer than a minute or two to apply a niacinamide cream. If both products are thick or sticky, wait until the skin absorbs the first layer to avoid mixing and diluting the products.

Is it better to use hyaluronic acid in the morning or at night?

If you have dehydrated skin, use hyaluronic acid serum both in the morning and at night. In the morning, it might help hydrate your skin and prepare it for the day ahead. At night, it might help repair and rejuvenate your skin while you sleep. Be sure to follow up with a moisturizer to lock in the hydration.

Which face serum is best?

  • Vitamin C Daily Glow Face Serum With Vitamin C & Turmeric for Radiant Skin - 30 ml. ...
  • Skin Correct Face Serum with Niacinamide and Ginger Extract for Acne Marks and Scars - 30 ml. ...
  • Vitamin C Daily Glow Face Serum 10 ml. ...
  • Rice Water Dewy Active Serum With Rice Water & 10% Niacinamide For Glass Skin - 50 ml.

Is niacinamide or retinol better?

Retinol is usually more effective than niacinamide. The adverse side effects of retinol are not present in niacinamide. From a molecular standpoint, retinol mainly penetrates the skin's outer layer. Niacinamide can permeate the skin more deeply than retinol, mainly when made with soy components.

Do and don'ts niacinamide?

Don't use it with exfoliating ingredients: Niacinamide can increase skin sensitivity, so it's best to avoid using it with exfoliating ingredients such as salicylic acid and glycolic acid. Don't use it if you have an allergy: Niacinamide, like any other skincare ingredient, can cause allergic reactions in some people.

Should I use hyaluronic acid or niacinamide first?

When used together, always go with applying hyaluronic acid first, followed by Niacinamide. By following this, you would be able to attract plenty of hydration first. After that, apply Niacinamide to help regulate sebum production and help with the minimization of pores.

What are the side effects of using niacinamide on your face?

Niacinamide is possibly safe when taken in doses up to 900-1500 mg daily. It might cause side effects such as stomach upset, gas, dizziness, headache, and rash. When applied to the skin: Niacinamide is possibly safe. Niacinamide cream might cause mild burning, itching, or redness.

What reacts badly with niacinamide?

Niacinamide works well with other skincare ingredients, including retinol and hyaluronic acid. However, some ingredients, like vitamin C, may interact negatively with niacinamide. Therefore, it's recommended to use products containing these ingredients at different times of the day or on alternate days.

What not to mix with hyaluronic acid?

However, there are certain ingredients that should not be mixed with hyaluronic acid:
  • AHAs and BHAs: AHAs (alpha hydroxy acids) and BHAs (beta hydroxy acids) are chemical exfoliants that can help improve skin texture and unclog pores. ...
  • Benzoyl Peroxide: Benzoyl peroxide is a common ingredient found in acne treatments.

What is the best combination with niacinamide?

Niacinamide + salicylic acid is what you need in your skincare routine. Salicylic acid is best known for its deep-cleansing properties and deep-penetrating action to unclog pores and slough off dead and dry skin. The antibacterial and anti-inflammatory properties of salicylic acid help clear away pustules and papules.

What are the 3 most important skin care products?

The 3 Most Important Skin Care Products
  • Sunscreen. You're probably already aware of how over-exposure to the sun can lead to skin cancer. ...
  • Cleanser. Number two on our list of the most important skin care products is a cleanser. ...
  • Moisturizer. Your skin cells need moisture in order to properly function.

What are the best hyaluronic acid serums?

Our Top Picks
  • Best Hyaluronic Acid Serum Overall: SkinCeuticals Hyaluronic Acid Intensifier Multi-Glycan, $182.
  • Best for Fine Lines: Alastin HA Immerse Serum, $127.
  • Best Custom Serum: Prose Custom Serum, $64.
  • Highest HA Concentration: Peter Thomas Roth Water Drench Hyaluronic Cloud Serum, $68.

Is niacinamide good for inflammation?

Niacinamide has been shown to ease inflammation, which can help calm redness due to conditions like acne, rosacea and eczema. It can also soothe irritation caused by strong exfoliants like retinol or glycolic acid that remove dead cells from the surface of your skin.

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