Botox® and similar products are usually supplied by manufacturers in vials of 50 or 100 powdered dosage units. It must be reconstituted with saline for subcutaneous injection.
Using an appropriate-sized needle and syringe, draw up 1.25 mL or 2.5 mL of 0.9% nonpreserved sterile saline (see dilution table). Disconnect the syringe from the needle, then gently mix BOTOX® Cosmetic with the saline by rotating the vial. Record the date and time of reconstitution in the space on the label.
If 50units of BOTOX are diluted in 1.5cc of saline and then drawn up in a 5cc syringe, then all 50units are in that syringe.
The recommended dose is 200 Units of BOTOX per treatment, and should not be exceeded. Reconstitute a 200 Unit vial of BOTOX with 6 mL of 0.9% non-preserved saline solution and mix the vial gently.
The ratio: 1 ml of preserved saline : to one vial of Dysport (300 units) OR. 1 ml of preserved saline : to one vial of Botox (100 units)
Botox is mixed with normal saline (bacteriostatic) and can last for several weeks under proper refrigeration. In most practices, it is used up the same day or within a few days.
One of the considerations for appropriate dosing is the volume of dilution, which has varied widely among practitioners. Each vial of botulinum exotoxin A is freeze-dried, containing 100 U of toxin. Most clinicians use between 1.0 and 3.0 mL of saline for dilution, but some report using dilutions of up to 10 mL.
Yes you can dilute botox with 1% lidocaine and you will have the same effect. However the injection will sting because of the ph in lidocaine and the area will be numb for about 30 minutes. The Botox and normal saline will not sting.
Some products that may interact with this drug include: certain antibiotics (including aminoglycosides such as gentamicin, polymyxin), anticoagulants (such as warfarin), Alzheimer's disease drugs (such as galantamine, rivastigmine, tacrine), myasthenia gravis drugs (such as ambenonium, pyridostigmine), quinidine.
Mixing the toxin with too much saline increases the risk of complications because a dilute solution is more likely to migrate into other muscle areas, he says, causing problems like a droopy eyelid, double vision or a droopy lip. And a watered-down injection isn't as likely to hold up.
An average Botox procedure uses about 50 units at a time, with the maximum safe amount being 100 units. Typically, you can expect more Botox units if you want to target more dynamic wrinkles like frown lines, forehead lines, or smile lines.
50 units of Botox would be excessive to fully treat forehead rhytids (horizontal forehead lines), but it may be appropriate to treat both the glabella and forehead. A typical dosage for the forehead is 20 units. 50 units would be more appropriate as a Dysport dosage.
Botox is measured in “units.” There are 100 units in one syringe of Botox.
Patients often question how their Botox is being diluted. We reconstitute our botox with 2 cc of bacteriostatic saline.
TIP: Always use bacteriostatic normal saline as the diluent as per manufacturer guidance. Reconstituting with sterile water can cause the client great discomfort during treatment.
Gently inject any remaining saline into the vial to avoid foam formation. If the vacuum does not pull the saline into the vial, then XEOMIN must be discarded. Remove the syringe from the vial and mix XEOMIN with the saline by carefully swirling and inverting/flipping the vial—do not shake vigorously.
“If you're starting with skin that's healthy, your Botox and fillers will last longer,” contends Dr. Peredo. Her medicine-cabinet recommendations include products that contain retinol, hyaluronic acid, peptides and antioxidants. “Having good skin care will also help extend your results.
Answer: Use of retinol and vitamin C post injections
Gently putting on your skin products after 4 hours post botox or juvaderm is safe. Both retinol and vitamin C will not interfere with either products.
Be extra gentle when applying skincare products and steer clear of retinol, glycolic acid, and exfoliating agents for 24 to 48 hours post-treatment to minimize the risk of irritation, says Dr.
The manufacturer recommends that Botox be reconstituted in unpreserved saline and used within 5 hours of dilution, after which it should be disposed of.
The use of EMLA cream is a rapid and effective method of decreasing pain during the percutaneous administration of Botox for aesthetic facial enhancement. Pain is reduced by more than 60% when EMLA is applied 30 minutes before treatment.
Up till now, there is no known antidote for Botox! Which means that there is no fast way to dissolve Botox of reverse its symptoms. Time is the only thing that is going to help Botox go away.
The recommended dilution is 100 Units/10 mL with preservative-free 0.9% Sodium Chloride Injection, USP (see Table 1). Dispose of any unused saline.
"Facial exercise speeds Botox's wrinkle-reducing effects: Simple facial exercises shortly after injection get quicker results by one day." ScienceDaily.
Deep injections are defined in this article as approxi- mately 6–10-mm deep, sometimes on or near periosteum. Medium depth injections are described in this article as ap- proximately 2–5-mm deep, placed under the skin, passing the overlaying muscle (if there is one) and into the targeted muscle.