Similar to retinol, niacinamide should not be used with acidic skincare ingredients like alpha hydroxy acids and beta hydroxy acids. Ordinary niacinamide combined with an acid can cause a bad chemical reaction of redness and flushing.
Niacinamide generally works well with most products, but it's best not to combine it with vitamin C (ascorbic acid) in the same routine as it can cause irritation. Additionally, avoid using it with strong exfoliants or retinoids in high concentrations to prevent skin sensitivity. For more, check out my Quora Profile.
Niacinamide works well with other skincare ingredients, including retinol and hyaluronic acid. However, some ingredients, like vitamin C, may interact negatively with niacinamide. Therefore, it's recommended to use products containing these ingredients at different times of the day or on alternate days.
Gallbladder disease: Niacinamide might make gallbladder disease worse. Kidney dialysis: Taking niacinamide seems to increase the risk of low platelet levels in people with kidney failure who are on dialysis. Stomach or intestinal ulcers: Niacinamide might make ulcers worse.
Mistake 2: Pairing Niacinamide With Incompatible Ingredients
While Niacinamide pairs well with most active ingredients, layering it with an unstable form of Vitamin C or acids like AHAs, BHAs may lead to flare-ups – especially for people with sensitive skin.
Some may also have skin discoloration due to using niacinamide combined with other active ingredients that are too harsh for your skin type. Niacinamide can also cause problems when it's mixed with the following substances: Acids, including lactic acid, glycolic acid, and azelaic acid.
Niacinamide and hyaluronic acid
While you may not see any significant results during the first few weeks, there should be a notable difference by about 4 weeks. After 8 weeks, you should notice more hydrated, smoother, and toned skin.
Safe but not totally for people with sensitive skin. As mentioned above, niacinamide seems to have an irritating effect when used with concentration formulas. Redness and itching are some of the common reactions. Although these are rare issues, they may still cause a great impact on someone's skin health.
Take for example Vitamin C and Niacinamide - two active ingredients we don't recommend using together in the same routine. The key word here is routine. You can use Niacinamide 10% + Zinc 1% in the AM routine and Ascorbyl Glucoside Solution 12% in the PM routine -- just not together in the morning or evening.
Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
Purging should end if the breakouts last longer than these 6 weeks. Purging usually occurs when you start a new skincare product that accelerates the turnover rate of your skin cells. The most common culprits behind purging are acids (AHA, BHA), retinoids, vitamin C, or even niacinamide.
Niacin and niacinamide may make allergies worse by increasing histamine. People with low blood pressure should not take niacin or niacinamide because they may cause a dangerous drop in blood pressure.
DON'T MIX: AHA/BHA and niacinamide
Niacinamide is used to treat hyperpigmentation and reduce fine lines and wrinkles, while alpha hydroxy acids (AHAs) and beta hydroxy acids (BHAs) are chemical exfoliants. To understand why niacinamide shouldn't be mixed with AHAs and BHAs, you need to consider pH.
For general skin tone correction, a niacinamide concentration between 4-5% is often effective and well-tolerated by most individuals. For those looking to tackle more pronounced hyperpigmentation, a higher concentration of 10% may be beneficial, though it's important to monitor the skin for any signs of irritation.
“Niacinamide is best absorbed on damp skin,” the dermatologist suggested. If you are using it in combination with other active skincare ingredients, you can apply it on dry skin. “Otherwise, as a solo agent, application on damp skin gives best results,” dermatologist Aanchal Panth added.
How often should you use niacinamide? For optimal benefits, we recommend using niacinamide either daily or twice a day. Whether you apply niacinamide once or twice a day will depend on your skin type, skin concerns and which other ingredients are contained within your morning and night routines.
Similar to retinol, niacinamide should not be used with acidic skincare ingredients like alpha hydroxy acids and beta hydroxy acids. Ordinary niacinamide combined with an acid can cause a bad chemical reaction of redness and flushing.
Consider pairing your niacinamide face serum with hyaluronic acid for an enhanced skincare regimen. Combining niacinamide with hyaluronic acid can brighten, hydrate, and plump up your skin. Apply niacinamide serum on a cleansed skin and let it absorb. After a few seconds, follow up with hyaluronic acid face serum.
What are the side effects of Niacinamide? Topical application is completely safe and may not cause any skin problems for a healthy person. People with sensitive skin may face mild redness, itching, or a burning sensation. Stomach upset.
How long does niacinamide take to work? Generally, you should start to see results after 2-4 weeks of twice daily usage (depending on the severity of your skin concerns and the concentration of your niacinamide formula). Ongoing use is required for continued improvement and maintained results.
Is 20% niacinamide too strong? While 20% niacinamide is potent, the independent Cosmetic Ingredient Review Expert Panel has concluded that it is safe to use concentrations up to this amount.