What to avoid after using niacinamide?

Author: Prof. Jorge Bogan  |  Last update: Saturday, April 5, 2025

Niacinamide and AHAs / BHAs Similar to retinol, niacinamide should not be used with acidic skincare ingredients like alpha hydroxy acids and beta hydroxy acids. Ordinary niacinamide combined with an acid can cause a bad chemical reaction of redness and flushing.

What should not be used with niacinamide?

Niacinamide generally works well with most products, but it's best not to combine it with vitamin C (ascorbic acid) in the same routine as it can cause irritation. Additionally, avoid using it with strong exfoliants or retinoids in high concentrations to prevent skin sensitivity. For more, check out my Quora Profile.

What should I put on my skin after niacinamide?

Use a few drops of niacinamide serum on your face and neck, gently patting it into the skin. Serums have a lightweight texture, allowing the active ingredient to penetrate deeply. After applying the serum, use a moisturizer to lock in hydration and further support your skin barrier.

What does niacinamide react badly with?

Niacinamide works well with other skincare ingredients, including retinol and hyaluronic acid. However, some ingredients, like vitamin C, may interact negatively with niacinamide. Therefore, it's recommended to use products containing these ingredients at different times of the day or on alternate days.

Does niacinamide interact with anything?

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with NIACINAMIDE. Niacinamide might slow blood clotting. Taking niacinamide along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

6 MONTHS OF THE ORDINARY NIACINAMIDE | I will stop 🛑 using it on my acne skin *not a clickbait* !!

What cancels out niacinamide?

Niacinamide and vitamin C

This combination sparks a lot of debate among skincare experts. Some say that since both niacinamide and vitamin C contain antioxidants, they cancel each other out and might even lead to irritation.

What conflicts with niacinamide?

Take for example Vitamin C and Niacinamide - two active ingredients we don't recommend using together in the same routine. The key word here is routine. You can use Niacinamide 10% + Zinc 1% in the AM routine and Ascorbyl Glucoside Solution 12% in the PM routine -- just not together in the morning or evening.

When should I avoid niacinamide?

Don't use it with exfoliating ingredients: Niacinamide can increase skin sensitivity, so it's best to avoid using it with exfoliating ingredients such as salicylic acid and glycolic acid. Don't use it if you have an allergy: Niacinamide, like any other skincare ingredient, can cause allergic reactions in some people.

How to know if niacinamide is working?

Niacinamide and hyaluronic acid

While you may not see any significant results during the first few weeks, there should be a notable difference by about 4 weeks. After 8 weeks, you should notice more hydrated, smoother, and toned skin.

How long does niacinamide purging last?

Purging should end if the breakouts last longer than these 6 weeks. Purging usually occurs when you start a new skincare product that accelerates the turnover rate of your skin cells. The most common culprits behind purging are acids (AHA, BHA), retinoids, vitamin C, or even niacinamide.

What can I layer over niacinamide?

You can (and should) consider layering niacinamide and retinol in the same routine, especially if you have sensitive skin. Retinol is a well-known ingredient that helps reduce the appearance of fine lines, wrinkles and other signs of aging.

Is 10% niacinamide too much?

For general skin tone correction, a niacinamide concentration between 4-5% is often effective and well-tolerated by most individuals. For those looking to tackle more pronounced hyperpigmentation, a higher concentration of 10% may be beneficial, though it's important to monitor the skin for any signs of irritation.

What compliments niacinamide?

Check out the list of ingredients that positively combine with niacinamide to benefit your skin effectively:
  • Niacinamide and vitamin C. ...
  • Niacinamide and retinol. ...
  • Niacinamide and salicylic acid. ...
  • Niacinamide and hyaluronic acid. ...
  • Niacinamide and Centella Asiatica.

Why is my skin getting darker after using niacinamide serum?

Some may also have skin discoloration due to using niacinamide combined with other active ingredients that are too harsh for your skin type. Niacinamide can also cause problems when it's mixed with the following substances: Acids, including lactic acid, glycolic acid, and azelaic acid.

What are the disadvantages of niacinamide on face?

What are the side effects of Niacinamide? Topical application is completely safe and may not cause any skin problems for a healthy person. People with sensitive skin may face mild redness, itching, or a burning sensation. Stomach upset.

What are the precautions for niacinamide?

Precautions
  • Allergies: Niacinamide can make allergies more severe because they cause histamine, the chemical responsible for allergic symptoms, to be released.
  • Diabetes: Niacinamide might increase blood sugar. ...
  • Gallbladder disease: Niacinamide might make gallbladder disease worse.

What can niacinamide not be mixed with?

DON'T MIX: AHA/BHA and niacinamide

Niacinamide is used to treat hyperpigmentation and reduce fine lines and wrinkles, while alpha hydroxy acids (AHAs) and beta hydroxy acids (BHAs) are chemical exfoliants. To understand why niacinamide shouldn't be mixed with AHAs and BHAs, you need to consider pH.

Should I put niacinamide on dry or wet?

“Niacinamide is best absorbed on damp skin,” the dermatologist suggested. If you are using it in combination with other active skincare ingredients, you can apply it on dry skin. “Otherwise, as a solo agent, application on damp skin gives best results,” dermatologist Aanchal Panth added.

Which moisturizer is best after niacinamide serum?

Consider pairing your niacinamide face serum with hyaluronic acid for an enhanced skincare regimen. Combining niacinamide with hyaluronic acid can brighten, hydrate, and plump up your skin. Apply niacinamide serum on a cleansed skin and let it absorb. After a few seconds, follow up with hyaluronic acid face serum.

What are the rules for applying niacinamide?

Knowing When to Use Niacinamide 10% Zinc 1%
  • Apply Niacinamide 10% Zinc 1% both morning and night. ...
  • Use Niacinamide 10% Zinc 1% if you have red, oily skin. ...
  • Avoid using vitamin C products with Niacinamide 10% Zinc 1%. ...
  • Stop using Niacinamide 10% Zinc 1% if your skin gets irritated.

Does niacinamide remove dark spots?

Niacinamide, a vitamin B3 derivative, is effective at reducing hyperpigmentation, capable of lightening dark spots significantly after several weeks' usage. Importantly, niacinamide is NOT a skin bleaching agent.

Which skin type should not use niacinamide?

In general, niacinamide is considered suitable for all skin types and, per the Cleveland Clinic, is rarely associated with side effects. Still, as with any skincare ingredient, it's best to introduce it to your skincare routine slowly to help minimize the potential for redness or irritation.

Can you use caffeine and niacinamide together?

Application Tips

Remember, the combination of caffeine and niacinamide can be used daily, both morning and evening, to achieve the best results.

What to avoid when using niacinamide serum?

Niacinamide might not reach its full effectiveness when mixed with AHAs or BHAs. Moreover, this combination could be overwhelming for your skin, leading to adverse effects such as skin peeling, redness, and itchiness.

Do you put retinol or niacinamide first?

It is not unusual to find a combination of niacinamide and retinol in a single skincare product, but you can use niacinamide and retinol as separate steps in a consistent routine. If you're using separate products, it is recommended that you apply retinol first then move forward with niacinamide application.

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