What is the best moisturizer for tretinoin users?

Author: Kenyon Dietrich I  |  Last update: Monday, November 24, 2025

Three inexpensive moisturizers that our physicians love are Vanicream Daily Facial Lotion with Hyaluronic Acid, Neutrogena Hydroboost Gel, and The Ordinary Hyaluronic Acid Serum. All three of these are affordable, non-comedogenic,and blend well with tretinoin.

What is the best moisturizer when using tretinoin?

Vanicream Moisturizing Cream is excellent over tretinoin. It's a very simple, bare bones moisturizer, but it's very effective--thick and heavily moisturizing. I tried CeraVe and a few others, and they just weren't enough for the dryness that accompanies a tret routine.

What moisturizer not to use with tretinoin?

Unless your skin care specialist tells you otherwise, it is especially important to avoid using the following skin products on the same area as tretinoin: benzoyl peroxide, salicylic acid, *lactic acid, *glycolic acids, *citric acid, high strength ascorbic acid. These acids & actives will increase skin irritation.

How to keep face moisturized when using tretinoin?

To prevent skin dryness, people using tretinoin should use a moisturizer. Additionally, as it can make their skin photosensitive, it is advisable to apply tretinoin once a day, in the evening. Individuals who use tretinoin for acne will likely notice their acne worsening right after they begin treatment.

What is the best combination with tretinoin?

One of the most popular hydrating ingredients, Hyaluronic acid is excellent to pair with Tretinoin in compounded treatments. It helps to counteract the dryness and flaking effects of Tretinoin by drawing moisture into the skin, keeping it plump and hydrated.

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What serum is best to mix with tretinoin?

Hyaluronic acid and tretinoin tend to balance each other. While tretinoin can sometimes be drying,¹⁰ hyaluronic acid acts as a moisturizing humectant,¹¹ helping to alleviate potential adverse effects. These findings suggest that using hyaluronic acid and tretinoin together can be a beneficial skincare strategy.

Is tretinoin 3 times a week enough?

You should aim to use tretinoin every night, however, you must start slowly as your skin needs to get used to it. The first 2 weeks apply it 2 to 3 nights per week, after that try applying it every other day, and then if your skin can handle it, apply it every night.

Can I use hyaluronic acid with tretinoin?

Hyaluronic acid can also be used in combination with Clindamycin gel and Tretinoin when treating acne because it helps moisturize the skin. Hyaluronic acid can be combined with almost all other skin care ingredients because it helps to hydrate, plump, and protect the skin.

What helps dryness from tretinoin?

For patients using tretinoin for the treatment of acne: Regular use of water-based creams or lotions helps to reduce skin irritation or dryness that may be caused by the use of tretinoin.

What is the sandwich method of tretinoin?

Option one: The sandwich technique

After washing your face, apply a layer of moisturiser. Allow it to dry down for 5-10 minutes. Then, apply a pea-sized amount of tretinoin to your entire face. Allow this to dry down for 5-10 minutes.

Can I use CeraVe AM moisturizer with tretinoin?

The best budget moisturizer to use with tretinoin cream

CeraVe prides itself on creating products that restore skin barrier function. This why their products are rich in hyaluronic acid and essential ceramides. This product is great for sensitive skin, it's non-comedogenic and suitable for AM and PM use.

What is the best tretinoin cream?

Top Picks
  • Best Overall: Agency by Curology Future Formula, $40.
  • Best Customizable: Ro Custom Rx Treatment, $58.
  • Best for Mature Skin: Nurx Tretinoin Cream, $30.
  • Best for Crow's Feet: Musely The Eye Serum, $39 and up.
  • Best for Acne: Hers Prescription Acne Cream, $29 and up.
  • Best for Dark Spots: Wisp Firm Up!

Can I use vitamin C with tretinoin?

Dr Malvina Cunningham: Retinoids like tretinoin and vitamin C work well together as they both promote collagen production and enhance each other's effect. Vitamin C is generally less of an irritant so these can often be applied in combination. Retinoids like tretinoin and niacinamide work well too.

What is the best moisturizer over retinol?

The Best Moisturizers to Use After Retinol

Hyaluronic acid is the ultimate hydrator, she says, while products with ceramides help restore the skin barrier and lock in moisture. She also suggests using a formula that's fragrance-free (to prevent further irritation) and non-comedogenic (to avoid clogging pores).

Which sunscreen is best to use with tretinoin?

DeVito recommends tretinoin for everyone above the age of 30. They should be using sunscreen during the day and tretinoin during the night. When it comes to which sunscreen to use, DeVito prefers a mineral-based one with zinc oxide or titanium dioxide.

Does tretinoin work better without moisturizer?

This depends on your skin and how it reacts to tretinoin. You can begin treatment by applying to clean dry skin. If you notice increasing dryness or slight redness, you can apply moisturizer before applying tretinoin and after or you can mix moisturizer with tretinoin.

What moisturizer is best with tretinoin?

Three inexpensive moisturizers that our physicians love are Vanicream Daily Facial Lotion with Hyaluronic Acid, Neutrogena Hydroboost Gel, and The Ordinary Hyaluronic Acid Serum. All three of these are affordable, non-comedogenic,and blend well with tretinoin.

What are the negative long-term effects of tretinoin?

What harm does Tretinoin do to the skin?
  • It makes the skin significantly more vulnerable to UV damage.
  • It causes contact irritant and photosensitivity reactions.
  • It damages the skin's barrier.
  • It increases chronic inflammation which in turn disrupts barrier function.
  • Its use in one study has been linked to premature death.

What does tretinoin purge look like?

Skin purging is common, but doesn't necessarily happen to everyone. In fact some people don't experience it at all. For those of us who do suffer from purging, it can look like: breaking out in pustules (pimples), the appearance of flaky, peeling skin, irritation and dry patches.

What Cannot be mixed with tretinoin?

Avoid other topical retinoids, and skin care products containing retinol, with tretinoin. You may also want to avoid salicylic acid, glycolic acid, and erythromycin gel (Erthygel), as these ingredients and products can cause dryness.

How long to wait to put on moisturizer after tretinoin?

Once you've massaged the Tretinoin onto your skin, you can apply your serums and/or moisturiser if you use these at night. There isn't a golden rule about how long to wait before applying these as different formulations of Tretinoin take different times to absorb. If in doubt, wait for 15-20 minutes.

Does tretinoin peeling ever stop?

Some people may notice that this side effect goes away within a few weeks of use, while others may have flaky skin for up to two months. Regardless of how long it takes to subside, tretinoin peeling is temporary and will go away once your skin gets used to the product.

How to tell if tretinoin is working?

After 4-6 weeks, your skin will get used to Tretinoin and will begin to be noticeably smoother and more even. Depending on how often you use Tretinoin, you may begin to see full benefits by this point. A lot of the initial irritation will settle down and true “retinization” of your skin is in full force.

What is the best cleanser for tretinoin?

Wash face thoroughly with a mild soap or a gentle alcohol-free non-soap cleanser such as Neutrogena Fresh Foaming Wash, Cetaphil cleanser, or CeraVe cleanser.

Should I use tretinoin on my neck?

The skin on the neck is thinner and more sensitive, so it may not tolerate tretinoin well, causing irritation. However, if you want to address signs of ageing on your neck, you may benefit from using tretinoin there. To avoid irritation, start with a lower frequency on your neck and build up as your skin tolerates it.

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