The 0.1% tazarotene cream produced significantly higher treatment success rates than the 0.05% tretinoin cream at weeks 12 and 20.
Conclusions: Tazarotene 0.1% cream can offer superior efficacy over tretinoin 0.05% emollient cream in the treatment of facial photodamage, particularly with respect to the speed of improvement.
Tazarotene (Tazorac, Avage) is another type of retinoid that also comes in a cream or a gel, but is usually more expensive than tretinoin. In studies, it is as effective as tretinoin for photoaging and wrinkles but can cause more skin irritation.
Tretinoin for Wrinkles: The Research
Compared to over-the-counter anti-aging products for men, tretinoin is significantly more effective, with numerous scientific studies showing that it can treat wrinkles, age spots and other age-related skin issues.
Tretinoin is a medication used to treat acne and sun-damaged skin. It can't erase deep wrinkles, but it can help improve the appearance of surface wrinkles, fine lines, and darks spots.
Does Retin-A (tretinoin) help reverse skin aging? Yes. Retin-A, whose active ingredient is tretinoin, has been shown to have positive effects on both the deeper collagen layers of your skin as well as the upper most layer that is comprised of skin cells.
Preliminary results from the tazarotene versus tretinoin trial suggest that once-daily tazarotene is more efficacious than once-daily tretinoin in reducing the numbers of papules and open comedones, and achieves a more rapid reduction in pustules. Both drugs appear to be equally efficacious against closed comedones.
The 0.1% tazarotene cream produced significantly higher treatment success rates than the 0.05% tretinoin cream at weeks 12 and 20. Between the 0.05% formulations, tazarotene and tretinoin were comparable in treatment success rates, although in OIA, tretinoin tended to provide higher improvement rates.
Retinaldehyde: This is an OTC retinoid that is stronger than retinol but not as strong as prescription topical retinoids. Tazarotene: Sold under the brand names Fabior, Tazorac, Avage, and others, this is a prescription topical retinoid often used to treat psoriasis .
In addition, several over-the-counter products containing retinoids, such as retinol, are available. Because they're not as strong (and thus less irritating), they are not as effective in reducing wrinkles as tretinoin; but they do improve the appearance of photo-aged skin.
1% tretinoin, or one unit of tretinoin per 100 units. The weakest cream contains . 005% tretinoin, or approximately 5% as much tretinoin as the strongest . 1% cream.
Topical retinoids are prescribed to treat acne. They are also commonly used as anti-aging treatments. Besides tretinoin, other topical retinoids include Tazorac (tazarotene) and Differin (adapalene). Differin is more aptly described as a retinoid-like compound, to be precise, but works the same way.
For the purposes of skin care, tretinoin can be thought of as a more concentrated version of retinol. This means that tretinoin is stronger than retinol. This difference in strength can help guide your decision-making when it comes to choosing a skin care product. Your skin is affected by more than what you put on it.
Tazarotene 0.1% gel (once daily) is more effective than tretinoin 0.025% gel (once daily) in reducing the numbers of papules and open comedones, and achieves a more rapid reduction in pustules in mild to moderate facial acne. Alternate-day tazarotene 0.1% gel is as effective as once-daily adapalene 0.1% gel.
Like other acne medications, tretinoin needs time to have a noticeable impact on acne. For the most part, scientific research shows that it typically starts to produce improvements after about 12 weeks (approximately three months).
Tazorac is a brand name for tazarotene, and Retin-A is a brand name of tretinoin. Other medications in the retinoid class include retinol, adapalene, alitretinoin and bexarotene.
For aging skin, dermatologists like to prescribe tretinoin and retinoic acid (Retin-A, Renova, Refissa) that is "100 times" as potent as the retinol-containing products sold without prescription, Jacob says. "Tretinoin works better because it has a stronger capability of preventing the breakdown of collagen," she says.
Studies have found that tazarotene can reduce fine wrinkles caused by sun damage. Other studies have also found that the drug can improve fine wrinkles, dark spots, skin roughness, and elasticity, and reduce pore size in sun-damaged skin.
Tazarotene topical 0.1% cream is used to help reduce fine facial wrinkles and certain types of dark and light spots on the face in patients who use a total skin care program and avoid sunlight. Tazarotene topical cream and gel are used to treat psoriasis.
According to the most recent FDA Enforcement Report, Allergan recalled 42,359 tubes of Tazorac in 30-g and 100-g sizes because the gel at the 24-month stability test fell slightly below regulatory specifications for product concentration and content uniformity.
First, the answer is yes, retinol can make wrinkles worse, especially when you first start using it. What is happening is a drying effect, and one can get epidermal sliding from separation from the dermis.
After 6 months. At 6 months, your skin continues to improve with new collagen in place and fresh blood vessels to bring in skin nutrients. Looking at your skin, it would appear more smooth and firm.
After 6-9 months of regular Tretinoin use, you may notice firmer, less saggy skin around the eyes and jawline and fewer wrinkles.