What does hyaluronic acid react with?

Author: Mr. Jonas Rippin V  |  Last update: Sunday, September 14, 2025

Mechanism of Action Hyaluronic acid, a chief component of the extracellular matrix, is found throughout various human tissues such as the skin, eyes, connective tissue, and synovium. Due to hyaluronic acid's highly anionic proprieties, it can attract water to swell and create volume and provide structural support.

What should you not use hyaluronic acid with?

What Not to Mix with Hyaluronic Acid: Expert Advice for Your Skincare Routine
  • Retinol and Hyaluronic Acid: A Powerful Combination. ...
  • However, there are certain ingredients that should not be mixed with hyaluronic acid: ...
  • Step 1: Cleansing. ...
  • Step 2: Toner/Mist. ...
  • Step 3: Antioxidant Serum. ...
  • Step 4: Moisturizer. ...
  • Step 5: Sunscreen.

Does hyaluronic acid interact with anything?

How does hyaluronic acid interact with other products? Products that combine hyaluronic acid with other medications or compounds may have some risks of side effects. It's important to tell your healthcare provider about all medications that you're taking, including supplements, vitamins, etc.

Why does my skin react badly to hyaluronic acid?

Hyaluronic acid holds 1000 times its weight in water, which is great for retaining hydration. However, too much can cause it to pull moisture from deeper in the dermis into your epidermis, leaving the deeper layers of your skin dehydrated.

Is there a downside to hyaluronic acid?

The most common adverse effects associated with hyaluronic acid filler are pain, bruising, redness, itching, and swelling. These side effects are self-limited and typically last no more than seven days.

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Why am I getting pimples after using hyaluronic acid?

This may be due to the increased moisture in the skin, which can create a breeding ground for bacteria. If you experience acne after using a Hyaluronic Acid serum, try reducing the frequency of use or switching to a different product.

Which moisturizer to use after hyaluronic acid?

As for what moisturizer to pair with your favorite hyaluronic acid serum? Dr. Shah suggests one with ceramides or niacinamide. “Ceramides hydrate the skin, and both ceramides and niacinamide help strengthen the skin barrier, which allows the skin to hold on to moisture and stay more hydrated,” she says.

What skincare should not be mixed?

Retinoids don't combine well with AHAs, benzoyl peroxide, salicylic acid, or vitamin C due to potential stability issues and skin sensitivities, and soap-based cleansers can also reduce vitamin C's skin benefits.

Can I use vitamin C and hyaluronic acid together?

While vitamin C and hyaluronic acid can be used separately for impressive outcomes, they are also a power duo when applied in tandem. In fact, vitamin C and hyaluronic acid are often mixed - either in one serum formula, or layered in a skincare regime.

What is the rule of hyaluronic acid?

The Only Rule for Hyaluronic Acid? Always Apply It on Damp Skin! It might sound surprising, but when hyaluronic acid is applied to dry skin, it can have the opposite effect, leaving your skin even more dehydrated.

What happens if you use too much hyaluronic acid on your face?

That's right—using too much HA in a dry climate can make your skin drier. Imagine applying HA in your serum, moisturizer, and those enticing sheet masks you love so much—a triple threat. In a dry environment, all that HA could backfire, sucking moisture from your own skin's reserves.

What depletes hyaluronic acid?

As is the case for other natural skin-strengthening components, such as collagen and elastin, our bodily reserves of hyaluronic acid deplete with age. Other lifestyle factors, including unprotected exposure to UV rays, pollution and tobacco smoke, can speed up this natural decline.

Is hyaluronic acid hard on the liver?

10. Is Hyaluronic Acid Bad For Your Liver? In the case of patients with liver diseases, it is advised to avoid using HA as the increased levels of HA in the bloodstream can cause thrombosis. Hence, user discretion and medical supervision are advised.

What are the precautions for hyaluronic acid?

Avoid activities such as jogging, soccer, tennis, heavy lifting, or standing on your feet for a long time. Temporary pain or swelling in the knee joint may occur after receiving hyaluronic acid injection. Call your doctor if the pain or swelling in the knee persists or becomes worse after receiving this medicine.

What not to mix with peptides?

For that reason, mixing peptides and glycolic acid is not recommended. Why shouldn't these acids be mixed with peptides? The reason peptides and salicylic acid as well as peptides and glycolic acid aren't efficacious ingredient combinations is because peptides are susceptible to hydrolysis when exposed to acids.

Which serums are not to use together?

PRODUCT COMBINATIONS THAT DON'T WORK TOGETHER
  • RETINOL SERUM + VITAMIN C. ...
  • RETINOL SERUM + AHAS/BHAS. ...
  • AHAS/BHAS + VITAMIN C. ...
  • NIACINAMIDE SERUM + VITAMIN C. ...
  • TRANEXAMIC ACID. ...
  • SALICYLIC ACID SCALP TREATMENT + GLYCOLIC ACID SCALP TREATMENT. ...
  • PRESCRIBED/OTHER ACTIVES TREATMENTS. ...
  • HYALURONIC ACID SERUM + RETINOL/AHAs/BHAs.

Is hyaluronic acid an AHA or BHA?

Rather than an AHA or BHA, hyaluronic acid is a sugar molecule. Your body naturally produces hyaluronic acid. It's a goopy, slippery substance that helps lubricate and hydrate your whole body, including your skin, joints and eyes. “Hyaluronic acid helps bind water to collagen, which traps water in the skin.

What combination skin should avoid?

Avoid using harsh, alcohol-based toners, over-exfoliating your skin, and using heavy, oil-based products. These can exacerbate the imbalances in your skin, leading to issues in both the oily and dry areas. Remember, skincare is a personal journey, and what works for one person may not work for another.

What to avoid when using hyaluronic acid?

3 Hyaluronic Acid Mistakes To Avoid For Happy, Hydrated Skin
  • You're not applying hyaluronic acid to damp skin. It's easy to forget this rule but it's so! ...
  • You're not applying hyaluronic acid in the right order. ...
  • You're not following hyaluronic acid with an oil and/or moisturiser.

What goes over hyaluronic acid?

“Once the hyaluronic acid comes into contact with water, it will know exactly what to do and what to bind to,” he says. Be sure to follow up your face serum with a moisturizer. “Moisturize first to help seal in hydration and then layer on cosmetics after,” adds Zeichner.

What happens if you don't use moisturizer after hyaluronic acid?

Using a moisturizer is an essential step after applying hyaluronic acid. The moisturizer will help seal hydration into the skin and help hyaluronic acid absorb correctly if the air around you is dry.

How long does skin purging last with hyaluronic acid?

Typically, a purge is likely to last from 4-6 weeks after adding a new product into your routine. This includes products and treatments that contain retinoids, hyaluronic acid, azelaic acid and niacinamide.

How to stop skin purging immediately?

If the skin purging stage is really troublesome, it can be helpful to decrease the frequency of your actives by alternating days of use. Stick with it - in time, things will likely improve. When the frequency of new spots starts to reduce, increase the frequency of your actives again.

Why is my face reacting to hyaluronic acid?

An increasing number of reports have appeared regarding side effects to these products. It is now known that reactions to Hyaluronic acid are related not only to technical faults of the injections, but also to immune responses, including delayed hypersensitivity and granulomatous reactions.

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