What are the disadvantages of tranexamic acid?

Author: Andy Luettgen  |  Last update: Sunday, October 5, 2025

This medicine may increase your or your child's risk of developing blood clots. Check with your doctor right away if you or your child have swelling and pain in your arms, legs, or stomach, chest pain, trouble breathing, loss of sensation, confusion, or problems with muscle control or speech.

When should you avoid tranexamic acid?

Tranexamic acid is not suitable for some people. To make sure it's safe for you, tell your doctor before taking this medicine if you: have ever had an allergic reaction to tranexamic acid or any other medicine. have ever had a blood clot in a vein (deep vein thrombosis) or in your lungs (pulmonary embolism)

Can tranexamic acid be harmful?

This medicine may cause serious allergic reactions including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention.

Is tranexamic acid a high risk medication?

Tranexamic acid injections have been added to the Institute for Safe Medication Practices' (ISMP's) 2024 List of High-Alert Medications in Acute Care Settings. “High-alert” medications have an increased risk of causing significant harm to patients when they are incorrectly administered.

What is the warning of tranexamic acid?

Immediate action required: Call 999 or go to A&E now if: you suddenly get shortness of breath, or a very sharp pain in your chest, and start coughing or coughing up blood – this may be a sign of a blood clot in your lungs (pulmonary embolism)

Tranexamic Acid (TXA) - Critical Care Medications

Can tranexamic acid affect the heart?

Iacobellis, G. & Iacobellis, G. (2004) Combined treatment with tranexamic acid and oral contraceptive pill causes coronary ulcerated plaque and acute myocardial infarction. Cardiovascular Drugs and Therapy, 18, 239–240.

What not to mix with tranexamic acid?

Most frequently checked interactions
  • Acetylsalicylic Acid (aspirin)
  • Adderall (amphetamine / dextroamphetamine)
  • Adrenalin (epinephrine)
  • Benadryl (diphenhydramine)
  • Claritin (loratadine)
  • Cymbalta (duloxetine)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • Iron Sulfate (ferrous sulfate)

Can tranexamic acid cause stroke?

Some studies have shown that TXA increases the risk of stroke [5]. Furthermore, although a meta-analysis noted that either mortality or thromboembolic events was few and was not increased in TXA group compared to non-treatment group, the authors still admonish for routine use of TXA in cardiac surgery [6].

Can tranexamic acid damage kidneys?

With its antifibrinolytic properties, tranexamic acid may harm the kidneys by favoring the formation of blood clots affecting kidney vessels and causing cortical necrosis.

What medication has a black box warning?

Black Box Warnings
  • Arixtra / Lovenox. ...
  • Warfarin. ...
  • Fentanyl Transdermal Patches. ...
  • Furosemide. ...
  • Morphine. ...
  • Infliximab. ...
  • Promethazine. ...
  • Epoetin alfa (Epogen)

What is a natural alternative to tranexamic acid?

Additionally, a systematic review of three clinical trials found that ginger capsules and myrtle fruit syrup significantly reduced menstrual duration and blood loss compared to a placebo 4. Pomegranate flower capsules were also as good as tranexamic acid at reducing blood loss 4.

Does tranexamic cause hair loss?

Transient amnesia. Tremors. Hypomenorrhoea (excessive menstrual bleeding) or dysmenorrhoea (painful menstruation) Increased hair shedding.

Can you get a blood clot from tranexamic acid?

Tranexamic acid does not affect any type of contraception, including the combined pill or emergency contraception. However, talk to your doctor if you're taking the combined pill. There may be a very small increased risk of having a thrombosis (a blood clot inside a vein) if you also take tranexamic acid.

Will I start bleeding again when I stop taking tranexamic acid?

Yes! Tranexamic acid doesn't stop the natural process of menstruation, it simply stabilizes the blood clots that form after the inner lining of the uterus is gone.

Does tranexamic acid cause weight gain?

It's effects are reversible. Possible unwanted side effects: Many women stop having periods when taking this drug. Common unwanted effects include stomach pain, feeling sick, headaches, dizziness, tiredness, weight gain, hot flushes and breast tenderness. What is it?

What happens to uterine lining when taking tranexamic acid?

Tranexamic acid helps to stop blood clots from breaking down, so it reduces bleeding. It will help the lining of your daughter's womb to clot when she is having a period and will reduce the heavy bleeding. It will not stop the period altogether.

Can tranexamic acid cause blood clots in brain?

Tranexamic acid may cause allergic reactions, which can be serious. Stop taking tranexamic acid and get help right away if you have any of the following symptoms of a serious allergic reaction. Blood Clots.

Is tranexamic acid safe for heart?

Tranexamic acid reduces blood loss and transfusion requirements in cardiac surgery but may increase the risk of coronary graft thrombosis.

What does tranexamic acid do to the brain?

Tranexamic acid (TXA) is an antifibrinolytic agent that inhibits clot breakdown and decreases bleeding. Early TXA administration has been shown to reduce mortality from head injury and improve neurologic recovery at 6 months in patients with traumatic intracranial hemorrhage (ICH).

Does tranexamic acid affect blood pressure?

Your doctor will decide what dose to give you based on a blood test. No reduction in dosage is necessary. If you are given too much Tranexamic Acid you may experience temporary low blood pressure (you may feel faint or dizzy on standing). Talk to your doctor or nurse immediately.

How long can you safely take tranexamic acid?

Tranexamic acid is licensed for the treatment of menorrhagia. The recommended dosage is 1 g three times daily for up to four days, to be initiated when menstruation has started. The dose may be increased to a maximum of 4 g daily.

Can you take vitamin D with tranexamic acid?

Interactions between your drugs

No interactions were found between tranexamic acid and Vitamin D3. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Which two serums cannot be used together?

Skincare ingredients not to mix
  • Retinoids or retinol and benzoyl peroxide. ...
  • Retinoids or retinol and vitamin C. ...
  • Retinoids or retinol and salicylic acid. ...
  • Retinoid or retinol and AHAs/BHAs. ...
  • Vitamin C and AHAs/BHAs. ...
  • Vitamin C and benzoyl peroxide. ...
  • Niacinamide and AHAs / BHAs. ...
  • Benzoyl peroxide and hydroquinone.

Can I take Tylenol with tranexamic acid?

Interactions between your drugs

No interactions were found between tranexamic acid and Tylenol.

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