Medication Summary Antibiotics used to treat anaerobic infections usually suffice for other types of
For systemic P. acnes infections, treatment with penicillin or vancomycin has proven to be effective, although P. acnes biofilm formation can limit the access of antibiotics to the site of infection.
Results. P. acnes was isolated from 227 patients; 224 isolates (98.7%) were susceptible to doxycycline and 220 (96.9%) were susceptible to tetracycline, followed by clindamycin and clarithromycin in 101 (44.5%) and 102 (44.93%) isolates, respectively.
Propionibacterium-associated PJI treated with surgery in combination with long-term antibiotic administration had a successful outcome at 1- and 2-year follow-up irrespective of whether the patient was treated with rifampicin.
Benzyl-penicillin should be the first-line antibiotic treatment option for IE caused by Propionibacterium spp.
Antibiotics used to treat anaerobic infections usually suffice for other types of Cutibacterium infections. C acnes generally is highly susceptible to a wide range of antibiotics. These include the penicillins, carbapenems, and clindamycin. In addition, vancomycin and teicoplanin have been used.
Oral therapies included beta-lactams (amoxicillin, penicillin V, ampicillin, cloxacillin and dicloxacillin) - with or without probenecid - in five (56%) studies [11-15]; fluoroquinolones (ciprofloxacin) in combination with rifampin in one (16%) [10]; and sulfonamide, aureomycin and linezolid in one study each [9,16,17] ...
The penicillins (penicillin G and amoxicillin) and cephalosporins (cephalothin and ceftriaxone) showed strong activity against P. acnes, with many isolates showing MICs lower than the lowest antibiotic concentration on the Etest strip.
The infection can quickly and severely damage the cartilage and bone within the joint, so prompt treatment is crucial. Treatment involves draining the joint with a needle or during surgery. Antibiotics also are usually needed.
Propionibacterium acnes is a gram-positive human skin commensal that prefers anaerobic growth conditions and is involved in the pathogenesis of acne (Kirschbaum and Kligman, 1963). Acne is one of the most common skin diseases, affecting more than 45 million individuals in the United States.
Overall, antibiotics have been used for the acne treatment for several decades, and the antibiotic resistance of P. acnes is a result of antibiotic use in the treatment of acne. P. acnes was highly sensitive to cyclines (doxycycline and tetracycline).
For example, it may take up to 24 to 48 hours (1 to 2 days) for a fever, a common symptom of bacterial infections, to improve. But this can vary based on the infection you're treating and how severe it is. It typically takes 1 to 2 weeks for doxycycline to completely clear an infection.
In ruminants, propionibacteria reduce nitrate to nontoxic nitrogen compounds. Members of the genus Propionibacterium are widely used in the production of vitamin B12, tetrapyrrole compounds, and propionic acid, as well as in the probiotics and cheese industries.
They are found in acne, prosthetic joints, cerebrospinal fluid shunts, endocarditis, and osteomyelitis. They have been identified as a cause of postoperative endophthalmitis of a chronic granulomatous nature, almost exclusively found in patients with intraocular lenses (IOLs).
In acne, the bacteria known as Propionibacterium acnes (or P. acnes for short) can have an effect on the development acne 'lesions' (e.g. spots). P. acnes lives on the skin and is commonly found within hair follicles, where it feeds on dead skin cells and sebum, which is the oil produced by your skin.
Serious bacterial infections can be effectively treated with antibiotics. These medicines either kill the bacteria or stop them multiplying. This helps your body's immune system fight the bacteria. Your doctor's choice of antibiotic will depend on the bacteria that is causing your infection.
RICE method.
If you think your joint inflammation is due to a sudden injury, the RICE (rest, ice, compression, and elevation) method is the first line of treatment to reduce pain and swelling. See an orthopedist if the pain and swelling don't diminish after RICE treatment.
Benzoyl peroxide (BPO) is a bactericidal agent commonly used for treating acne vulgaris and has been shown in multiple randomised studies to reduce the prevalence of P acnes on the shoulder [10,12,14]. Application of 5% BPO three days prior to surgery has been shown to effectively reduce P acnes culture [11,12,14].
The skin commensal Propionibacterium acnes, recently renamed Cutibacterium acnes, along with the other major pathophysiological factors of increased seborrhea, hyperkeratinization of the pilosebaceous unit, and inflammation, has long been implicated in the pathogenesis of acne.
Tea tree oil is a natural antibacterial and anti-inflammatory, which might kill P. acnes, the bacteria that causes acne.
Culture-negative NVE is usually treated with vancomycin and gentamicin. In patients who previously have received antibiotics, initial therapy should consist of either ampicillin-sulbactam plus gentamicin (3 mg/kg/d) or vancomycin plus gentamicin and ciprofloxacin.
Conclusions: Long term survival following infective endocarditis is 50% after 10 years and is predicted by early surgical treatment, age < 55 years, lack of congestive heart failure, and the initial presence of more symptoms of endocarditis.
The term "broad spectrum antibiotics" was originally used to designate antibiotics that were effective against both gram-positive and gram-negative bacteria, in contrast to penicillin, which is effective chiefly against gram-positive organisms, and streptomycin, which is active primarily against gram-negative bacteria.