Why can't you mix hyaluronic acid and vitamin C?

Author: Ms. Audra Kihn MD  |  Last update: Friday, August 22, 2025

Research shows using hyaluronic acid and vitamin C together can enhance each ingredient's skin-beneficial powers (4). There is a school of thought that these two ingredients cannot be used together, because hyaluronic acid must be applied to wet skin, and vitamin C to dry skin.

What happens if you use vitamin C with hyaluronic acid?

When used together, these two ingredients protect against harmful free radicals that irritate the skin and contribute to photoageing. The power of vitamin C to brighten and even out the skin also complements hyaluronic acid's ability to keep the skin soft and plump, for overall healthy-looking skin.

Do you put vitamin C or hyaluronic acid first?

The correct order to apply vitamin C and hyaluronic acid serum is to apply the vitamin C serum first, followed by the hyaluronic acid serum. Vitamin C is best absorbed on clean skin, while hyaluronic acid helps to hydrate and lock in moisture after the vitamin C.

What can hyaluronic acid not be mixed with?

However, there are certain ingredients that should not be mixed with hyaluronic acid:
  • AHAs and BHAs: AHAs (alpha hydroxy acids) and BHAs (beta hydroxy acids) are chemical exfoliants that can help improve skin texture and unclog pores. ...
  • Benzoyl Peroxide: Benzoyl peroxide is a common ingredient found in acne treatments.

Can I use the ordinary hyaluronic acid with vitamin C?

  • Vitamin C and hyaluronic acid (HA) can be used together, safely, in your skin care routine.
  • Including both vitamin C and HA in your skin care routine will provide better anti-aging results than choosing only one.

Doctor V - Hyaluronic Acid, Mistakes You Are Making | Skin Of Colour | Brown Or Black Skin

Is it better to put vitamin C on wet or dry skin?

You'll want to apply your vitamin C serum to clean, dry skin. “As far as active ingredients go, vitamin C is quite unstable, and it's easily affected by outside elements such as air, light and moisture,” says board-certified dermatologist and LovelySkin CEO Dr. Joel Schlessinger.

In what order should I use ordinary products?

You'll want to apply water-based treatments first, followed by anhydrous (water-free) solutions or oil formulations, followed by creams or suspensions. This means that you would apply a water-based serum such as Amino Acids + B5 before an anhydrous serum or oil such as Retinol 0.2% in Squalane..

What is the best pair for hyaluronic acid?

As a pair, vitamin C and hyaluronic acid benefit the skin in numerous ways, though the duo is most often used to help combat the visible signs of aging.

Which serums are not to use together?

PRODUCT COMBINATIONS THAT DON'T WORK TOGETHER
  • RETINOL SERUM + VITAMIN C. ...
  • RETINOL SERUM + AHAS/BHAS. ...
  • AHAS/BHAS + VITAMIN C. ...
  • NIACINAMIDE SERUM + VITAMIN C. ...
  • TRANEXAMIC ACID. ...
  • SALICYLIC ACID SCALP TREATMENT + GLYCOLIC ACID SCALP TREATMENT. ...
  • PRESCRIBED/OTHER ACTIVES TREATMENTS. ...
  • HYALURONIC ACID SERUM + RETINOL/AHAs/BHAs.

What is the best peptide serum for face?

Our Top Peptide Serums
  • Best for Inflammation: Eighth Day Regenerative Serum, $195.
  • Best for Dullness: Best for Dullness: Drunk Elephant Protini Powerpeptide Resurf Serum, $82.
  • Best Budget: The Ordinary Multi-Peptide + Copper Peptides 1% Serum, $32.
  • Best Eye Cream: Dermalogica Phyto Nature Lifting Eye Cream, $127.

Is it better to use hyaluronic acid in the morning or at night?

If you have dehydrated skin, use hyaluronic acid serum both in the morning and at night. In the morning, it might help hydrate your skin and prepare it for the day ahead. At night, it might help repair and rejuvenate your skin while you sleep. Be sure to follow up with a moisturizer to lock in the hydration.

How to pair vitamin C with hyaluronic acid?

In conclusion, you can use both vitamin C and HA in the same skincare routine, but remember to use vitamin C first on clean, dry skin, since it is the fussier ingredient. HA is more tolerant, so use it as a moisturizing toner in between steps—an HA-infused moisturizer or a nighttime application.

What does toner do for your face?

what does toner do for your face? It removes any dirt or grime that remains after cleansing, but does so gently. And toners help prep your skin for those products you're putting on after — think serums, moisturizers, night creams, etc. The outer layer of your skin is a mixture of oils and proteins.

Which goes first vitamin C or hyaluronic acid?

Layering vitamin C and hyaluronic acid serums

To layer vitamin C and hyaluronic acid serums, always apply vitamin C first to cleansed, dry skin. Be sure to leave time for your vitamin C to sink in, then follow up with your hyaluronic acid.

How long to wait between hyaluronic acid and moisturizer?

Wait for the serum to absorb: Give the serum some time to absorb into your skin. This usually takes a few minutes. You'll know the serum has been absorbed when your skin feels soft and smooth. Apply moisturizer: Once the serum has been absorbed, apply your moisturizer on top of it.

Which 2 serums should not be mixed?

Skincare ingredients not to mix
  • Retinoids or retinol and benzoyl peroxide. ...
  • Retinoids or retinol and vitamin C. ...
  • Retinoids or retinol and salicylic acid. ...
  • Retinoid or retinol and AHAs/BHAs. ...
  • Vitamin C and AHAs/BHAs. ...
  • Vitamin C and benzoyl peroxide. ...
  • Niacinamide and AHAs / BHAs. ...
  • Benzoyl peroxide and hydroquinone.

What serums Cannot be used with vitamin C?

Vitamin C is effectively an acid (it's sometimes known as ascorbic acid), so layering it with AHAs and BHAs like glycolic, salicylic, and lactic acids is a big no-no.

What serums cancel each other out?

Retinol and Benzoyl Peroxide

It is useless to use benzoyl peroxide, which is usually used to treat acne, and retinol together, says Paviol. The ingredients can cancel the positive effects of each other out and leave skin extremely dry and irritated.

What happens if you put too much hyaluronic acid on your face?

But like all good things, moderation is crucial. Overloading your skin with HA can lead to the paradoxical drying effect or even irritation. Less is often more. Tune into your skin's needs.

What hydrates better than hyaluronic acid?

While they're both effective hydration ingredients, polyglutamic acid has better performance and additional benefits to moisturize that hyaluronic acid does not have. Bondi says that “depending on the source, polyglutamic acid holds 4,000-5,000 times its weight in water.

Can I use hyaluronic acid every day?

Don't worry. Hyaluronic acid is acidic by name, but not by nature and won't exfoliate the skin or supercharge its turnover. For this reason, it's perfectly fine to use hyaluronic acid every day. “I would recommend using it once or twice a day,” says Dr Hextall.

What ordinary products cannot be mixed?

What Ordinary Products Should Not Be Mixed?
  • Avoid layering The Ordinary retinol products and The Ordinary vitamin C/antioxidant serums. ...
  • Avoid layering The Ordinary retinol products with The Ordinary exfoliants. ...
  • Don't layer The Ordinary niacinamide with The Ordinary vitamin C/antioxidant serums.

Why can't you use vitamin C and peptides together?

They both benefit the skin and keep the skin barrier strong and healthy. The more complicated answer is that it depends on your skin type. People with sensitive, redness-prone skin might notice that the Peptides and Vitamin C mix can result in more redness, irritation and itchiness.

Should I use retinol or hyaluronic acid first?

It is suggested to apply hyaluronic first on clean, damp skin, followed by retinol for dry skin. The moisturising hyaluronic acid will create a barrier and reduce irritation. The correct order of these two products depends significantly on your skin type and the product formulation you are using.

Previous article
Do temporary tattoos come off in water?
Next article
How long does it take to burn off fast food?