Is tranexamic acid better than vitamin C for hyperpigmentation?

Author: Dorris Green  |  Last update: Wednesday, January 14, 2026

They work in different ways, and are both beneficial. One isn't better than the other for fading dark spots. Tranexamic acid is more targeted toward reducing hyperpigmentation, while Vitamin C is better suited for general skin health and reducing all visible signs of ageing.

Is tranexamic acid better than vitamin C for dark spots?

When it comes to brightening the skin and addressing pigmentation concerns, both Vitamin C and tranexamic acid offer significant benefits. While Vitamin C provides multi-tasking benefits and can help with hyperpigmentation, tranexamic acid is a more specific ingredient for targeting dark spots and uneven skin tone.

Which acid is more effective for hyperpigmentation?

Kojic acid effectively penetrates through your skin layers and stops melanin production. This is why it is praised and readily used in hyperpigmentation treatments. The acid can also be used to prevent browning; it is a well-known and well-studied tyrosinase inhibitor.

How long does it take for tranexamic acid to fade hyperpigmentation?

It can take 8-12 weeks of regular use of tranexamic acid skin care products before you see a noticeable difference in skin tone and brightness.

Can I use vitamin C and tranexamic acid together?

There is some evidence to suggest that combining tranexamic acid (TXA) with vitamin C may have potential synergistic effects in addressing certain skin concerns. Both ingredients are known for their skin-brightening properties and can target hyperpigmentation through different mechanisms.

Doctor V - Tranexamic Acid Vs Alpha Arbutin For Pigmentation | Skin Of Colour | Brown Or Black Skin

What Cannot be combined with tranexamic acid?

Cautions with other medicines

Tranexamic acid can be taken with most other medicines. However, talk to your doctor or pharmacist if you're taking the combined contraceptive pill. There could be a very small increased risk of getting a blood clot if you take tranexamic acid as well.

What is the difference between vitamin C and kojic acid?

Kojic Acid is derived from fungi and works by inhibiting melanin production, helping to fade dark spots and hyperpigmentation. Vitamin C, a powerful antioxidant, protects the skin from damage caused by free radicals and promotes collagen production, leading to a firmer, more youthful appearance.

What percentage of tranexamic acid is effective for hyperpigmentation?

Results from a 12-week single-center clinical study in 55 Brazilian females revealed that a novel topical facial serum containing 3% tranexamic acid, 1% kojic acid, and 5% niacinamide was effective in treating mild-to-moderate PIH, with a significant decrease in MI at week 12 compared to baseline and control group.

What to not mix with tranexamic acid?

Most frequently checked interactions
  • Acetylsalicylic Acid (aspirin)
  • Adderall (amphetamine / dextroamphetamine)
  • Adrenalin (epinephrine)
  • Benadryl (diphenhydramine)
  • Claritin (loratadine)
  • Cymbalta (duloxetine)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • Iron Sulfate (ferrous sulfate)

Which serum is good for hyperpigmentation?

Alpha arbutin helps reduce melanin production, fade existing dark spots and prevent new ones from forming, making it a highly effective ingredient for addressing pigmentation issues. You can also use other face serums like azelaic acid, and vitamin C for pigmentation.

What fades hyperpigmentation the fastest?

Three types of skincare treatments fade hyperpigmentation marks fast:
  • Physical exfoliants.
  • Chemical exfoliants.
  • Brightening actives such as vitamin C, kojic acid, liquorice extract.

What is the number one treatment for hyperpigmentation?

Topical therapy is the recommended first-line treatment, with the gold standard being hydroquinone, which can be used alone or in combination with other agents.

What is the best acid for hyperpigmentation?

Glycolic acid treats acne, acne scars, hyperpigmentation, photodamage, dryness, melasma and age-related fine lines.

How quickly does tranexamic acid work?

It can take up to 24 hours for the medicine to take full effect.

Which is better for hyperpigmentation, niacinamide or tranexamic acid?

Tranexamic acid is more effective for deeper and more stubborn hyperpigmentation such as melasma.

Can I use tranexamic acid instead of vitamin C?

One isn't better than the other for fading dark spots. Tranexamic acid is more targeted toward reducing hyperpigmentation, while Vitamin C is better suited for general skin health and reducing all visible signs of ageing. Most people will benefit from using both, because each one targets different aspects of skin care.

What is the disadvantage of tranexamic acid?

This medicine may increase your or your child's risk of developing blood clots. Check with your doctor right away if you or your child have swelling and pain in your arms, legs, or stomach, chest pain, trouble breathing, loss of sensation, confusion, or problems with muscle control or speech.

How to layer vitamin c and tranexamic acid together?

How to use: apply your vitamin c serum first then layer it up your TRANEXAMIC acid serum for the best results!

Is niacinamide or vitamin c better for hyperpigmentation dermatologist?

Unlike niacinamide, Vitamin C can be irritating, especially for sensitive skin, and may not pair well with certain ingredients like retinol due to its low pH. Both niacinamide and ascorbic acid are effective for reducing hyperpigmentation, but they work best when used together.

How many days will tranexamic acid take to work on hyperpigmentation?

Oral tranexamic acid treatment benefits maximize after taking it for eight to twelve weeks. During this time, it limits a cellular process involved in producing melanin, the pigment that makes your skin dark and causes freckles.

Which is better for hyperpigmentation, Vitamin C or alpha arbutin?

Arbutin gives quicker results than vitamin C. Arbutin acts as hydroquinone, which means it has depigmenting factors. Vitamin C is not easily absorbed into the skin, whereas arbutin absorbs quickly into the skin. That's why arbutin is the best ingredient to include in your skincare routine.

Which acid is best for skin whitening?

Glycolic Acid

It is an alpha-hydroxy acid (AHA) derived from sugarcane. In low concentrations, glycolic acid produces desquamation of pigmented skin cells. About 30 to 70 per cent of glycolic acid can enhance the penetration of other skin lighteners such as HQ.

Is it OK to use kojic acid and Vitamin C together?

One compatible ingredient that can be used with Kojic acid is Vitamin C. When combined, this blend of these active ingredients can boost the skin's brightening and antioxidant effects. Vitamin C helps to further inhibit melanin production and promote collagen.

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