Over time, the Botox components are broken down into harmless particles called amino acids. The broken-down components are excreted from the kidneys as waste, or they're used in other proteins. As such, Botox either leaves your system completely or gets recycled in a harmless form.
And once it's in, it's in—for about four months, until it dissipates, and treatment is needed again. Once the protein stops functioning at the neuromuscular junction, it is broken down into its harmless components (amino acids) and either recycled for use in other proteins or excreted by the kidneys.
Unfortunately, there is no reversal treatment for Botox. Unlike dermal fillers that can be reversed by injecting hyaluronidase, there is no procedure to “undo” Botox. On a lighter note, you should know that even though you may have a bad Botox experience, it won't last forever, since the treatment is not permanent.
This is coincident with release of the catalytically active light chain that paralyzes transmission. Intraneuronal metabolism of light chain is via the ubiquitination-proteasome pathway. Systemic metabolism and elimination is assumed to be via the liver.
After you receive a Botox injection, your body will metabolize the drug over the next few months. When this happens, your body starts to create new neurotransmitters. When they're created, they override the botulinum toxin and allow your muscles to contract again.
Unfortunately, if your original injector administered too much Botox, the only thing to do is wait. That means you could spend anywhere from 3-6 months sidelined by botched Botox. Exercise, heat, and massages may help to work out bad Botox. Exercise increases blood flow and may help you flush out Botox faster.
Answer: Botox not harmful to liver or kidneys.
Botox injections are usually safe when you're under the care of a licensed and skilled health care provider. The procedure can result in unwanted results or even cause harm if it's given incorrectly. Possible side effects and unwanted results include: Pain, swelling or bruising at the injection site.
botulinum are heat-resistant, the toxin produced by bacteria growing out of the spores under anaerobic conditions is destroyed by boiling (for example, at internal temperature greater than 85 °C for 5 minutes or longer).
How your body clears Botox. Researchers aren't sure what happens to Botox as its effects wear off. However, they suspect your body metabolizes the toxin in the same way as other medications — with enzymes released from your liver.
The effects of Botox injections are temporary, lasting only about three to four months.
Because there may be redness and swelling almost immediately after BOTOX injections, many patients are tempted to ice their faces to alleviate these effects. However, while there's no issue with the cold, the pressure you apply with the ice pack may interfere with results.
Serious adverse effects after cosmetic use of botulinum toxin include dysphagia, muscle weakness, and allergic reactions [22, 23].
Within three to six months after Botox therapy, toxins wear off and muscles regain movement. As a result, wrinkles return and issues like migraines and sweating may resume.
You cannot see, smell, or taste the toxin, but taking even a small taste of food containing it can be deadly. Botulism is a medical emergency. If you or someone you know has symptoms of botulism, contact your doctor or go to the emergency room immediately.
Initial botulism symptoms may include double or blurred vision, drooping eyelids, slurred speech, difficulty swallowing, and difficulty breathing. These symptoms may be followed by a descending, symmetric muscle weakness that progresses over hours to days.
Muscle Atrophy and Adaptation: After long-term Botox use, some facial muscles may experience mild atrophy due to limited activity. This can actually benefit patients who prefer a smoother look, as muscle activity that causes wrinkles is minimized.
Previous rodent experimental studies have shown that botulinum toxin receptors exist in the CNS and that a small amount of botulinum toxin can pass through the blood-brain barrier [10, 11].
Botox for aesthetic purposes is a pure protein, meaning there is no bacteria and it cannot replicate, like the live protein mentioned above. Further, Botox is injected into the skin, not the bloodstream and is slowly metabolized by the body.
Prolonged muscle paralysis or atrophy following repeated Botox treatments can lead to alterations in muscle architecture, including muscle fiber composition and ability to contract.
Frontalis muscles
The frontalis muscles are located in the forehead and are responsible for creating frown lines. When Botox injections are administered too close to this area, it can affect the blood vessels and cause complications.