There was some evidence of carcinogenic activity in orally-exposed rodents. Increased skin tumor incidence has been reported in mice treated dermally. EPA has not classified hydroquinone for carcinogenicity.
With continued use, hydroquinone and mercury can build up in your body, which may cause harm. The FDA has received reports of serious side effects from the use of hydroquinone, including rashes, facial swelling, and permanent skin discoloration (ochronosis).
However, 4% Hydroquinone is a better topical hypopigmenting agent with rapid rate of clinical improvement when compared to 0.75% Kojic Acid cream. The side effects of both the hypopigmenting agents were not significant.
While oral consumption probably is not related to topical application, hydroquinone remains controversial because it actually is toxic to melanocytes. Hydroquinone, a phenolic compound chemically known as 1,4 dihydroxybenzene, functions by inhibiting the enzymatic oxidation of tyrosine and phenol oxidases.
You need a doctor's prescription to buy hydroquinone cream online or in a physical pharmacy. You can have a online consultation with a dermatologist. After the consultation they will issue a prescription containing for hydroquinone cream if it's safe and medically appropriate for you.
We recommend taking a 2 month break after 3 months of application. Since hydroquinone is a photosensitive agent, It is also important to use SPF 30 or higher daily when on hydroquinone.
Although it was originally believed that only high concentrations of hydroquinone were causal, there have been reports of ochronosis after use of 2% hydroquinone preparations.
The effect of hydroquinone on skin pigmentation is reversible. If you stop, the melanocytes affected by treatment start to resume normal activity, causing the blemishes or spots to gradually reappear.
Tretinoin is an anti-aging powerhouse, meaning it should have no problem dispatching fine lines and wrinkles. It does not work for deeper wrinkles. Hydroquinone doesn't work at all against fine lines and wrinkles, so stick to the collagen-boosting power of tretinoin.
However, while The Spot Cream is generally safe, one of the high-strength ingredients in a few of the formulas is hydroquinone, which could rarely lead to some serious health risks. And while Musely's 60-day Result Guarantee sounds generous, it's quite strict and requires a commitment to regular mobile app check-ins.
For discrete areas of hyperpigmentation, hydroquinone should only be applied to areas of discolouration and not the entire face. Your doctor will advise whether to use it locally or over a wider area.
With GRAS (Generally Recognized as Safe) status, hexylresorcinol is a great choice for beauty brands seeking to provide skin lightening and even toning benefits in their next skin care formula. Hexylresorcinol was introduced to the skin care market in 2007 under the trade name Synovea® HR.
Avoid using hydroquinone with peroxide products such as benzoyl peroxide or hydrogen peroxide, which can cause discoloration. 3. Avoid alpha hydroxy acids. The combination of hydroquinone and alpha hydroxy acids (AHAs) can irritate your skin.
This disease entity may be first noticed in newborns as their urine may be darker than normal. People are often without symptoms until later in life when the skin, sclera (white part of the eye), ears, and nose may develop pigmentary changes. Ear wax of a person with ochronosis will also be dark in color.
After your initial consultation, your dermatologist will give you a prescription for a skin lightening cream with hydroquinone. They will use a cream with no more than 4% hydroquinone in conjunction with the frequent application of an SPF 30 sunscreen for the best results.
How to treat hydroquinone-damaged skin? According to doctors, damage caused by the application of hydroquinone can be reversed by exposing the affected area to the sun. Also, you are recommended to use strong sunscreen along with hydroquinone. In case of irritation, apply anti-itch cream to the infected skin.
The lesions may develop gradually over 6 months to 3 years or longer. [8] Two recent case reports from India mention the occurrence of EO with use of 2% hydroquinone preparations for 7–8 years.
At present, there are no treatments specifically approved for alkaptonuric ochronosis. Reducing protein consumption may help those patients who receive their diagnosis early. Low protein diets have less of the amino acids phenylalanine and tyrosine, which produce homogentisic acid when metabolized.
For years, 4% Hydroquinone, a prescription drug, has been considered the gold standard for treating hyperpigmentation and is the key ingredient in our Obagi Nu-Derm® Systems.
Conclusions. We conclude that azelaic acid may be better than hydroquinone in reducing melasma severity as measured by the MASI. However, no significant difference between both treatments regarding the side effects.