Does tretinoin make you purge at first?

Author: Caroline Blick  |  Last update: Sunday, January 4, 2026

Skin purging is a common side effect of using tretinoin. It usually appears right after the medication is first used, or when you increase the dosage. This can be a shocking experience for new users.

How do you know if tretinoin is working?

After 4-6 weeks, your skin will get used to Tretinoin and will begin to be noticeably smoother and more even. Depending on how often you use Tretinoin, you may begin to see full benefits by this point. A lot of the initial irritation will settle down and true “retinization” of your skin is in full force.

How to start tretinoin without purging?

You can begin treatment by applying to clean dry skin. If you notice increasing dryness or slight redness, you can apply moisturizer before applying tretinoin and after or you can mix moisturizer with tretinoin. Talk to your Curology licensed dermatology provider for advice about your skin.

Should I pop tretinoin purge pimples?

Do not pick or squeeze the spots, as this can lead to inflammation or scarring. If this is Tretinoin purging or due to beta hydroxy acid (e.g. salicylic acid) or retinoid purging then you don't need to do anything else as these already treat acne breakouts.

Is tretinoin 3 times a week enough?

You should aim to use tretinoin every night, however, you must start slowly as your skin needs to get used to it. The first 2 weeks apply it 2 to 3 nights per week, after that try applying it every other day, and then if your skin can handle it, apply it every night.

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How long does tretinoin purge last?

Skin purging typically lasts anywhere between four to six weeks which is roughly in line with how long it takes for your skin cells to naturally turnover. During this phase, it might seem like your skin is getting worse but it should settle down and improve after you've passed this period.

What is the sandwich method for tretinoin?

Option one: The sandwich technique

After washing your face, apply a layer of moisturiser. Allow it to dry down for 5-10 minutes. Then, apply a pea-sized amount of tretinoin to your entire face. Allow this to dry down for 5-10 minutes.

What does tretinoin purging look like?

For some users, acne will flare up within the first few weeks of using tretinoin before it starts to reduce acne. Tretinoin purge is also referred to as “acne flaring.” In addition to increased acne, a tretinoin purge can also include dryness, peeling or flaking skin.

Does tretinoin peeling ever stop?

Some people may notice that this side effect goes away within a few weeks of use, while others may have flaky skin for up to two months. Regardless of how long it takes to subside, tretinoin peeling is temporary and will go away once your skin gets used to the product.

Does tretinoin unclog pores?

Tretinoin cream works by promoting rapid cell turnover, which helps unclog pores, smooth the skin's surface, and fade discolorations.

What are the negative long-term effects of tretinoin?

What harm does Tretinoin do to the skin?
  • It makes the skin significantly more vulnerable to UV damage.
  • It causes contact irritant and photosensitivity reactions.
  • It damages the skin's barrier.
  • It increases chronic inflammation which in turn disrupts barrier function.
  • Its use in one study has been linked to premature death.

What percentage of tretinoin users purge?

During the first few months of using tretinoin, some people experience an increase in their level of facial acne. This may be linked to tretinoin's effects on epidermal turnover. Research has found that up to 20 percent of people who use tretinoin experience the “purge” or “acne flaring” effects.

How long to let tretinoin sit before moisturizer?

Once you've massaged the Tretinoin onto your skin, you can apply your serums and/or moisturiser if you use these at night. There isn't a golden rule about how long to wait before applying these as different formulations of Tretinoin take different times to absorb. If in doubt, wait for 15-20 minutes.

How quickly does tretinoin turn over skin?

The bottom line. Retin-A (tretinoin) is a topical medication that's effective for the treatment of acne, wrinkles, and skin damage from the sun. It starts working within the first few weeks of treatment for acne, but can take 3 to 6 months for wrinkles.

Does tretinoin help smile lines?

Tretinoin, a topical retinoid, has proven to be a game-changer in the world of skincare. Its ability to stimulate collagen production and accelerate cell turnover can significantly diminish the appearance of deep smile lines, giving you a more youthful and rejuvenated look.

Does tretinoin cause weight gain?

If you experience any of the following symptoms, call your doctor immediately: fever; weight gain; swelling of the arms, hands, feet, ankles, or lower legs; shortness of breath; labored breathing; wheezing; chest pain; or cough.

Do I need to exfoliate if I use tretinoin?

You'll get more effective results from tretinoin than any other over-the-counter exfoliants like BHAs and AHAs. This is why there's usually no need to use other exfoliants when you're on tretinoin – it's best to avoid doubling up, which can damage the skin barrier and cause irritation.

Does tretinoin tighten skin?

Yes! Tretinoin can help tighten your skin to some extent. It works primarily by stimulating collagen production and accelerating cell turnover, which can in turn, improve skin texture and elasticity making the skin appear firmer and youthful.

What moisturizer goes well with tretinoin?

Three inexpensive moisturizers that our physicians love are Vanicream Daily Facial Lotion with Hyaluronic Acid, Neutrogena Hydroboost Gel, and The Ordinary Hyaluronic Acid Serum. All three of these are affordable, non-comedogenic,and blend well with tretinoin.

Does everyone purge when starting tretinoin?

“Skin purging,” or the “retinol uglies” as it's also known, are terms used to describe an initial flare of sensitive skin and acne breakouts at the start of a retinoid treatment. Skin purging is common, but doesn't necessarily happen to everyone. In fact some people don't experience it at all.

How to stop skin purging immediately?

If the skin purging stage is really troublesome, it can be helpful to decrease the frequency of your actives by alternating days of use. Stick with it - in time, things will likely improve. When the frequency of new spots starts to reduce, increase the frequency of your actives again.

How much should you rub in tretinoin?

Applying tretinoin to wet skin can irritate it. To use the cream, gel, or lotion form of this medicine: Apply just enough medicine to very lightly cover the affected areas, and rub in gently but well. A pea-sized amount is enough to cover the whole face.

Can I put tretinoin on active acne?

Historically, tretinoin (all-trans retinoic acid) has been used as a comedolytic agent to treat mild-to moderate acne. Used as a stand-alone treatment or in combination with antibacterials, its ability to stimulate the growth of new cells, unclog pores, and promote the normal flow of sebum is well-proven.

Where is the best place to put tretinoin?

Tretinoin is often used to treat a range of skin concerns around your T-zone, which includes your forehead and chin, two common areas for acne. Tret is very successful in the treatment — and even prevention — of acne, thanks to its powerful cell-regenerating and exfoliating abilities.

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