To put it plainly, Botox resistance (immunity) does occur in some patients. According to those who do recognize the phenomenon of Botox resistance, the numbers are low—about 1% to 3% of patients who are injected will develop toxin-blocking antibodies.
BOTOX resistance is a situation in which a patient either has built up antibodies against the botulinum toxin, or happens to metabolize the BOTOX drug exceptionally quickly. As a result, for these patients BOTOX injections provide underwhelming results, a very short-lived effect, or no effect at all.
Because Botox is a form of a toxin produced by a bacteria, the body can sometimes develop an immune response to the injections. This will cause the body to break down the Botox injections quickly so that they are no longer effective.
The results from Botox last anywhere between 2-6 months; the average result lasts about 3-4 months. Why does Botox eventually stop working? Your body makes new neurotransmitters all the time, so the “blocking” effect of Botox gradually wears off as these chemicals start circulating in your body again.
One in six people who have Botox injected into their face suffer complications such as bruising, headache, nausea and “frozen” features, a study into the anti-ageing treatment has found.
Botox side effects
Get emergency medical help if you have signs of an allergic reaction to Botox: hives, itching; wheezing, difficult breathing; feeling like you might pass out; swelling of your face, lips, tongue, or throat.
“If you're starting with skin that's healthy, your Botox and fillers will last longer,” contends Dr. Peredo. Her medicine-cabinet recommendations include products that contain retinol, hyaluronic acid, peptides and antioxidants. “Having good skin care will also help extend your results.
In general, Botox lasts 3-4 months. There will certainly be patients in which in lasts longer, in that 4-6 month range, or shorter, in that 2-month range. It is also common for first-timers to notice that it may not last as long initially but may last longer after the second treatment.
It can take up to one week for the Botox to show full effect. I would recommend giving it some time. Following up with your provider would be the next best step if you still do not see a result after a week.
Botox works by chemically binding and blocking acetylcholine release, causing a chemical denervation. Acetylcholine release requires docking and binding of the neurotransmitter vesicles to the presynaptic membrane. I am aware of no scientific evidence linking Botox and autoimmune disease.
After the age of 35, it may be too late to benefit from the preventive capacity of Botox®, especially if you have a very expressive face or fair skin, are genetically predisposed, or have unhealthy lifestyle habits such as using tan beds, overexposing yourself in the sun, or smoking.
There is no upper age limit for people who want to have Botox. In fact, many women enjoy the refreshed look they can get from Botox and complementary treatments when they are in their 60s or older.
Even if the masseter muscle is reached, failure to inject deeply enough can leave the lower parts of the muscle moving as normal while the top part is relaxed, creating a 'chipmunk' appearance. Practitioners should aim to inject at the site where the muscle meets the bone, using a longer ½” needle for best results.
FLS have been reported in between 1.7 and 20% of patients treated with various preparations of BoNT/A. Most patients have a mild to moderate symptoms lasting less than 2 weeks, but 66 serious AEs related to FLS were reported to the Food and Drug Administration between 1989 and 2003.
BOTOX® candidates should be in good overall health. This treatment is not suitable for those who suffer from or have a history of nerve damage or muscle conditions, such as Amyotrophic Lateral Sclerosis (ALS) or Multiple Sclerosis (MS).
The short answer to how long you should wait between Botox treatments is anywhere from three to four months for the best results. We recommend scheduling around this time frame, which is when most people begin to notice that their results begin to dissipate.
The most common reason that Botox does not work is that not enough was given. Botox is not a one size fits all treatment and the same dosage does not work for everyone. Some individuals may need additional Botox to reach an effective level of muscle weakness. The Botox may also be old, overdiluted, or fake.
The traditional Botox schedule calls for new injections every 3-4 months to treat glabellar lines—the horizontal lines on your forehead. A new study indicates that after two years of treatment, a good result can be achieved with less frequent injections.
Take a Zinc Supplement
In a study from the Journal of Drugs in Dermatology, researchers found that people who received Botox and then took a 50-milligram zinc supplement saw a significantly longer duration in their results.
Answer: Use of retinol and vitamin C post injections
Gently putting on your skin products after 4 hours post botox or juvaderm is safe. Both retinol and vitamin C will not interfere with either products.
Answer: Botox hit a nerve
Just as you have described, a nerve was hit along the hairline and feels like an electric sensation when touched. Though very uncommon this can happen with any kind of injection done. While it is painful for a bit, it will resolve on its own in the next week or two and stop hurting.
There's a common misconception that Botox makes you look older when it wears off. On the contrary, regular Botox treatments make you look younger even after the neurotoxin wears off.
It has been reported that frequent application of BoNT in short time or overdose might lead to botulism, which could endanger the physical and mental health of people, even their lives. The main clinical symptoms of botulism include muscle weakness, blepharoptosis, facial palsy, and rising difficulty.