When it comes to mixing all three together, the best order to apply them is by starting with retinol, followed by hyaluronic acid, and finally niacinamide. By applying retinol first onto a fully cleansed skin the ingredient can penetrate into the lower layers.
What Are the Benefits of Combining the Two? Good news: Retinol and hyaluronic acid actually have a synergistic effect. “They can be combined so that the benefits of retinol can be achieved more easily with concomitant use of hyaluronic acid, which helps to prevent retinol irritation,” says Hartman.
Niacinamide and retinol can be used together with a five-minute gap between application but are likely to be just as effective if you use them at separate times of the day.
Hyaluronic acid and niacinamide are water-based treatments that complement each other's hydrating effects and can be used together. You'll find a variety of cosmetics that contains both ingredients in their formulations but you can buy them separately and layer them up as well.
No matter which form you choose to incorporate your hyaluronic acid, it should be close to the final step in your routine. If you are using it in serum form, you'll apply it immediately after your retinol. If it is part of your moisturizer, it will be your last step.
When it comes to mixing all three together, the best order to apply them is by starting with retinol, followed by hyaluronic acid, and finally niacinamide. By applying retinol first onto a fully cleansed skin the ingredient can penetrate into the lower layers.
Start by applying hyaluronic acid on your cleansed face to replenish your skin with plenty of hydration first, and then follow up with niacinamide to regulate excess sebum production. Lastly, lock these active ingredients in with your favorite moisturizer. You can also use them at different time of the day.
Using niacinamide before retinol works well. So does combining them into one product. A 2016 study found that a product containing retinol, niacinamide, hexylresorcinol, and resveratrol improved fine lines, sallowness, wrinkling, hyperpigmentation, and skin tone.
Second, avoid anything with harsh ingredients like alcohol and fragrance, or anything with a high acid concentration. “The majority of over-the-counter (OTC) cosmetic creams, lotions, and serums are water based and contain less than 2 percent hyaluronic acid,” Frey explains.
Don't Mix: Retinol with vitamin C, benzoyl peroxide, and AHA/BHA acids. AHA and BHA acids are exfoliating, which can dry out skin and cause further irritation if your skincare routine already includes retinol.
Hyaluronic acid is best if they're looking to moisturize dry skin, while retinol works better by encouraging better skin by boosting collagen production. They have several benefits that can work in tandem for better results, though patients need to be careful with the exact formulations they use.
To apply a serum with retinol correctly, Smooth it onto clean skin before your moisturizer. Your serum will have a thinner consistency than your moisturizer, which is what determines the application order.
The best product you can use in conjunction with retinol, according to Dr. Zeichner, is a moisturizer, which can help hydrate skin and reduce the risk of irritation from retinol. “Some people even prefer to mix their retinol with a moisturizing cream to dilute it out,” he says.