Genetic predisposition
Some individuals may experience obesity or an inability to lose weight or certain metabolic disorders which are in fact the result of hereditary or genetic factors rather than lifestyle choices.
The Genetic Influence on Losing Weight
These genetic differences can impact metabolism, appetite regulation, and the distribution of body fat. For example, some individuals may have a genetic predisposition to a slower metabolic rate, making it harder for them to burn calories efficiently.
It is now well-established that overweight and obesity have a significant genetic component, with estimates of the contribution of genetic variation to observed variation in obesity-related phenotypes (such as BMI, fat mass, and leptin levels) ranging from 30 to 70 percent (Comuzzie et al., 1993, 1994, 1996).
A person's build depends largely on genetic factors, which is why it is difficult for a naturally thin person to put on weight. The human body can change to a limited extent through weight training and increased food intake. Gaining or regaining weight can be just as difficult as losing weight.
Lean muscle mass is more compact than fat. If you are muscular you can weigh quite a bit and not look fat. A person can be an ideal weight and have a lot of fat and look bulky. Another person can be overweight and have mostly muscle mass, and look lean and healthy.
Muscle helps keep up the rate at which you burn calories (metabolism). So as you lose weight, your metabolism declines, causing you to burn fewer calories than you did at your heavier weight. Your slower metabolism will slow your weight loss, even if you eat the same number of calories that helped you lose weight.
Early lifestyle interventions, bariatric surgery, and medications form the basis of the treatment of genetically predisposed obesity.
Weight gain and short-term fluctuations may happen for a variety of reasons, such as aging or making lifestyle and dietary changes. However, fast weight gain can be a sign of an underlying health condition, such as a problem with the thyroid, kidneys, or heart.
Some people have genetic variants that place them at higher risk of becoming skinny fat. Lifestyle factors such as a lack of exercise, an unhealthy diet, smoking, and alcohol consumption can also play a role.
Your body eventually adapts to your workout regime, so you burn fewer calories and slow down weight loss progress. Other health conditions: There are some medical conditions that can drive weight gain and make it harder to lose weight. These include hypothyroidism, polycystic ovarian syndrome and sleep apnea.
Genetic and environmental factors interact to regulate body weight. Overall, the heritability of obesity is estimated at 40% to 70%.
Weight loss resistance is a complex issue that is influenced by various factors, including hormonal imbalances, chronic stress, poor sleep quality, medications, poor gut health, thyroid disorders, sex hormone fluctuations, and blood sugar imbalance with insulin or leptin resistance.
An analysis of 143 studies revealed that phentermine-topiramate and GLP-1 receptor agonists (like liraglutide and semaglutide) are among the most effective medications for reducing weight in people with obesity. The typical body weight reduction with these medications is 6% to 11%.
If you're asking yourself, “Why am I gaining weight when I barely eat,” several factors may be at play. Your body may be holding onto fat stores if your eating habits are inconsistent or restricted. Or, your weight gain may be the effect of a sedentary lifestyle, medical condition, or long-term stress.
The 30/30/30 is a weight loss method that involves eating 30 g of protein within the first 30 minutes of your day and following it with 30 minutes of light exercise. This morning routine is rooted in sound science, and it could be a good way to increase your capacity to burn fat while keeping lean muscle.
Mostly, losing weight is an internal process. You will first lose hard fat that surrounds your organs like liver, kidneys and then you will start to lose soft fat like waistline and thigh fat. The fat loss from around the organs makes you leaner and stronger.
While it's a myth that muscle weighs more than fat—after all, a pound is a pound—it is denser, which means it takes up less space in the body. This may explain why you look slimmer but the scale hasn't budged. Water weight could also be a factor, according to strength and conditioning coach Brandon Mentore.