If you have mild or moderate acne, both tretinoin and adapalene are likely to produce a lasting, significant improvement if used consistently. On the whole, studies comparing tretinoin and adapalene typically find that tretinoin is slightly more effective as an acne treatment.
Accordingly, numerous clinical trials have compared adapalene and tretinoin in the management of acne vulgaris and concluded that tretinoin 0.05% gel exhibits a greater anti-acne efficacy than adapalene 0.1% gel, but has higher skin irritation potential.
“Topical retinoids such as tretinoin cream and topical benzoyl peroxide will deactivate each other,” says Dr. Mraz Robinson. “You can mix other forms of topical retinoids such as adapalene [now OTC] with benzoyl peroxide, but this can increase the risk for irritation and inability to tolerate the topicals.”
Conclusion: Adapalene 0.3% gel showed non-inferior efficacy to tretinoin 0.05% cream as treatment for photoaged skin, with a similar safety profile. Adapalene 0.3% gel may therefore be considered a safe and effective option for the treatment of mild or moderate photoaging.
Differin 0.1% Adapalene Gel, for example, can help treat acne. Studies have found evidence to suggest adapalene is just as effective as stronger retinoids, but the skin tends to tolerate it better.
In conclusion, tretinoin and adapalene contributed to the wound healing process resulting in an enhancement of collagen production, angiogenesis and granulation tissue formation.
For the purposes of skin care, tretinoin can be thought of as a more concentrated version of retinol. This means that tretinoin is stronger than retinol. This difference in strength can help guide your decision-making when it comes to choosing a skin care product. Your skin is affected by more than what you put on it.
On the whole, studies comparing tretinoin and adapalene typically find that tretinoin is slightly more effective as an acne treatment. In a review of tretinoin and adapalene, researchers found that tretinoin . 05 percent gel “exhibits a greater anti-acne efficacy” than adapalene 0.1 percent gel.
Conclusions: Adapalene offers comparable efficacy to tretinoin, but is less irritating. It represents a good alternative for the treatment of mild to moderate acne vulgaris in Chinese patients.
Retin-A (tretinoin) Cream and Gel and Differin (adapalene) are retinoids (a form of vitamin A) used for the topical treatment of acne vulgaris. Differin is available over-the-counter (OTC).
"You can use tretinoin or [over-the-counter] retinols forever."
The active ingredient is adapalene, which helps decrease swelling and inflammation, prevent breakouts, and treat scarring. According to Garshick, “it can help discoloration and textural changes that go along with acne scars by evening out the skin tone and boosting collagen production.”
The topical retinoids a play very important role in the treatment of acne vulgaris. However, their use is limited due to skin irritation. A new generation product, adapalene is a good choice in the treatment of acne vulgaris with less side effects and high efficacy confirmed by numerous clinical studies.
Which one should I use? If acne is your only concern, adapalene can improve your acne with less irritation. If you want to go beyond fighting acne and improve skin texture, tone, and appearance, Tretinoin is your best bet. Tretinoin is the only FDA-approved retinoid to prevent and treat photoaging.
Background: The efficacious acne treatment adapalene gel 0.1% is significantly less irritating than tretinoin of various concentrations and formulations, according to several clinical studies conducted predominantly in Caucasian patients.
As both photodamaged skin and atrophic acne scars share the feature of dermal matrix loss, adapalene 0.3% may potentially exert a beneficial effect in the treatment of atrophic acne scars, similar to its effect on photoaging.
Studies have shown a significant improvement of fine lines and wrinkles after just four weeks of tretinoin use, while the same level of improvement takes an average of 12 weeks for retinol 2. So you'll achieve the same level of improvement eventually, but tretinoin shows results faster.
Tretinoin gel, cream, or lotion requires a prescription because it's more powerful than retinol. Doctors prescribe tretinoin to treat skin conditions like: Acne. Psoriasis.
If you stop using the medication or are inconsistent with your treatment, any improvements you see may disappear over time. Always use the product as prescribed by your healthcare provider (Rodan, 2016).
First, the answer is yes, retinol can make wrinkles worse, especially when you first start using it. What is happening is a drying effect, and one can get epidermal sliding from separation from the dermis.
The only skin care product that can truly provide a slight tightening effect with regular use is Retin A, or Tretinoin. This is because Vitamin A helps speed up skin cell turnover, helping to boost collagen production.
Tretinoin, under the brand name Retin-A, was the first retinoid. It was used as an acne treatment in the 1970s, but researchers later discovered that it also fades actinic keratosis spots, evens pigmentation, and speeds the turnover of superficial skin cells.
Differin (adapalene)
Benzac (benzoyl peroxide) is the most effective over-the-counter treatment for mild acne. Treats acne. Differin (adapalene) is commonly used for treating acne, but, it can cause skin irritation. Available over-the-counter from many brands.
During the first few weeks of using adapalene, your acne might appear worse because the medication is working on pimples forming inside the skin. It may take 8 to 12 weeks to notice results from this medication.
It is very important that you use this medicine only as directed. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause irritation of the skin.