When to worry about unintentional weight loss?

Author: Prof. Otho Jerde MD  |  Last update: Monday, December 15, 2025

Your body weight can regularly fluctuate. But the persistent, unintentional loss of more than 5 per cent of your weight over 6 to 12 months is usually a cause for concern. Losing this much weight can be a sign of malnutrition. This is when a person's diet doesn't contain the right amount of nutrients.

How much unexplained weight loss is concerning?

When to Contact a Medical Professional. Contact your provider if: You or a family member loses more weight than is considered healthy for their age and height. You have lost more than 10 pounds (4.5 kilograms) or 5% of your normal body weight over 6 to 12 months or less, and you do not know the reason.

What is the most common cause of weight loss without trying?

Cancer is the most common cause of unintentional weight loss — more than 35% of people who see their doctor for weight loss have undiagnosed cancer. Adults with unexplained weight loss are at least 12 times more likely to have cancer than people who aren't experiencing weight loss.

What factors can contribute to unintended weight loss in older adults?

The risk factors for weight loss in the older adult can be classified into the following three main categories: physiologic factors (e.g., chronic and acute diseases), psychological factors (e.g., depression, bereavement) and social factors (e.g., isolation, social problems).

What does it mean when you lose weight not meaning to you?

Losing weight without trying may be a sign of a health problem. An unexplained drop in weight could be caused by many conditions. These include overactive thyroid (hyperthyroidism), diabetes, depression, liver disease, cancer or disorders that interfere with how your body absorbs nutrients (malabsorption disorders).

Expert explains when unintended weight loss should be cause for concern

Why am I not losing weight even though I am exercising and eating right?

Your body eventually adapts to your workout regime, so you burn fewer calories and slow down weight loss progress. Other health conditions: There are some medical conditions that can drive weight gain and make it harder to lose weight. These include hypothyroidism, polycystic ovarian syndrome and sleep apnea.

What is the 30/30/30 rule for weight loss?

The 30/30/30 is a weight loss method that involves eating 30 g of protein within the first 30 minutes of your day and following it with 30 minutes of light exercise. This morning routine is rooted in sound science, and it could be a good way to increase your capacity to burn fat while keeping lean muscle.

What are three things you would look for with unintended weight loss?

Unintentional weight loss
  • mental health conditions, such as depression, anxiety, eating disorders and obsessive compulsive disorder (OCD)
  • problems with digestion, such as coeliac disease or irritable bowel syndrome (IBS)
  • other health conditions, such as an overactive thyroid, type 2 diabetes or heart failure.

Which cancers cause weight loss?

Some types of cancer can also make it harder for your body to absorb nutrients (called malabsorption). Weight loss may be more common in lung cancer and upper gastrointestinal cancers such as pancreatic, stomach and esophageal cancer.

What autoimmune diseases cause weight loss?

Types of autoimmune disorders

Diabetes (Type I) – affects the pancreas. Symptoms include thirst, frequent urination, weight loss and an increased susceptibility to infection. Graves' disease – affects the thyroid gland. Symptoms include weight loss, elevated heart rate, anxiety and diarrhoea.

What tests are done for unexplained weight loss?

What tests to run for unintentional weight loss? Common tests include blood tests (CBC, thyroid function, blood sugar), urine tests, imaging tests (like X-rays or CT scans), and sometimes endoscopy or colonoscopy, depending on symptoms and medical history.

Which of the following cardiac disorders can cause unintentional weight loss?

Cardiac cachexia is unintentional severe weight loss caused by severe heart failure.

Why is unexplained weight loss a red flag?

Unexplained weight loss can be a symptom of diabetes, gastrointestinal disorders, some types of cancer, and even some mental health disorders such as depression.

When should weight loss be alarming?

As a rule of thumb, losing more than 5% of your weight over 6 to 12 months may indicate a problem.

What blood tests are done for weight loss?

This baseline blood test for weight loss measures the levels of several markers associated with metabolism, including a cholesterol and lipid panel, comprehensive metabolic panel (CMP), thyroid stimulating hormone (TSH) test, and a hemoglobin A1c (HbA1c) test.

What meds have weight loss as a side effect?

Weight loss was associated with the use of metformin, acarbose, miglitol, pramlintide, liraglutide, exenatide, zonisamide, topiramate, bupropion, and fluoxetine.

What disease causes skinny legs?

Acquired generalized lipodystrophy (AGL): Acquired generalized lipodystrophy (also called Lawrence syndrome) usually results in fat loss in your face, neck, arms and legs. Fat loss associated with AGL may occur rapidly over a few weeks or slowly over several months or even years.

When should I worry about weight loss?

The point at which unexplained weight loss becomes a medical concern is not exact. But many health care providers agree that a medical evaluation is called for if you lose more than 5% of your weight in 6 to 12 months, especially if you're an older adult.

Can GERD cause weight loss?

Once people have GERD and the condition becomes chronic, weight loss may occur due to eating- and appetite-related complications.

What is the 3 3 3 rule for weight loss?

3-By-3 Rule For Weight Loss, Per A Registered Dietitian

She reveals that this method consists of “eating 3 meals a day, drinking at least 3 bottles of water by 3 o'clock, and having at least 3 hours of exercise spread out throughout the week.”

Why am I getting skinny all of a sudden?

Eating disorders: Unexplained weight loss may be an early symptom of undiagnosed eating disorders like anorexia nervosa or bulimia nervosa. Heart failure: This can cause weight loss, especially in the later stages. Hyperthyroidism: This condition speeds up your metabolism and can lead to weight loss.

What is the 80 20 rule for weight loss?

The 80/20 rule is super simple: you focus on eating healthy foods 80% of the time and allow yourself to indulge in not-so-healthy foods for the remaining 20%. It's all about striking a balance—getting your body the nutrition it needs while still enjoying your favorite treats without feeling guilty.

What does 30g of protein look like for breakfast?

Here is a list of foods that provide roughly 30 grams of protein: 1.5 cups of Greek yogurt (opt for unsweetened and add your own toppings) 1 cup cottage cheese. 5 large eggs, or 2-3 eggs mixed with extra egg whites.

What is a reasonable amount of weight to lose in 30 days?

For most people, healthy weight loss is in the neighborhood of 1 to 2 pounds per week. That's 4 to 8 pounds per month.

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