When should I stop using tretinoin cream?

Author: Emma Rath  |  Last update: Wednesday, June 25, 2025

Topical tretinoin can cause your skin to become dry, red, swollen, blistered, or flaky. It may also cause your skin to itch, be painful, or feel like it is burning. Stop using topical tretinoin and call your healthcare provider if these symptoms become worse or do not go away.

When can I stop using tretinoin?

The skin will be more prone to sunburn, dryness, or irritation, especially during the first 2 or 3 weeks. However, you should not stop using this medicine unless the skin irritation becomes too severe.

How long should I use tretinoin cream?

Dr. Mohta says that tretinoin can be used long term, even your entire life, as tretinoin is commonly used for the treatment of acne, fine lines, wrinkles, and hyperpigmentation. Dr. Mohta, also says that it may be necessary to use tretinoin for a few weeks before you can notice changes in your skin.

Do you have to use tretinoin forever?

According to Dr. Mohta, to maintain the benefits you achieved over the past year, it is crucial to continue using tretinoin as part of your long-term skincare routine. You can safely use tretinoin long-term. Research has shown no negative effects even with 2-4 years of usage.

Is it OK to use tretinoin for years?

It's true that some people with persistent acne use tretinoin for years, but generally speaking, most stop once they have clearer skin or if they're no longer seeing results. Other people may continue to use tretinoin after their breakouts subside for the most part for maintenance therapy.

IS IT OVER FOR TRETINOIN - Why Everyone Is Stopping Tretinoin

Does skin go back to normal after tretinoin?

“The symptoms related to tretinoin purging typically involve acne breakouts, severe skin dryness and peeling, redness and irritation, but it is important to know that this phase is temporary and once it's over, the skin will generally begin to improve, and you will be able to see the positive effects.

Is tretinoin 3 times A week enough?

When you first start using tretinoin, you may start with a lower percentage that you apply just two or three times a week. After two weeks, if your skin is adjusting well to the tretinoin, you can consider increasing use to every night as tolerated.

What does tretinoin purge look like?

Skin purging is common, but doesn't necessarily happen to everyone. In fact some people don't experience it at all. For those of us who do suffer from purging, it can look like: breaking out in pustules (pimples), the appearance of flaky, peeling skin, irritation and dry patches.

Does tretinoin increase facial hair in females?

Dr Kiran acknowledges some evidence that suggests tretinoin may aid in hair growth: Tretinoin promotes cell turnover, which can help rejuvenate hair follicles. It may enhance the absorption of other hair growth treatments, such as minoxidil.

Should you take a break from tretinoin?

Skipping days gives your skin a rest. Once it starts feeling better, slowly work up to using it every day (or as directed by your healthcare provider). Don't stop using your treatment altogether. As your skin adjusts, dryness and peeling will taper off.

What are the negative long-term effects of tretinoin?

What harm does Tretinoin do to the skin?
  • It makes the skin significantly more vulnerable to UV damage.
  • It causes contact irritant and photosensitivity reactions.
  • It damages the skin's barrier.
  • It increases chronic inflammation which in turn disrupts barrier function.
  • Its use in one study has been linked to premature death.

What moisturizer is best with tretinoin?

Three inexpensive moisturizers that our physicians love are Vanicream Daily Facial Lotion with Hyaluronic Acid, Neutrogena Hydroboost Gel, and The Ordinary Hyaluronic Acid Serum. All three of these are affordable, non-comedogenic,and blend well with tretinoin.

What happens if I suddenly stop using tretinoin?

One common consequence of discontinuing tretinoin is a temporary worsening of skin texture and appearance. Without the regular use of tretinoin, the benefits it provides may gradually fade away. Skin may become rougher, and the appearance of fine lines and wrinkles may become more pronounced.

How long should you be on tretinoin for?

Tretinoin helps remove dead skin cells, allowing new cells to rise to the surface more efficiently. This stimulates collagen production and helps to reverse the effects of long-term sun exposure1. Tretinoin should be used for at least 6 months for maximum effect.

Should you cycle off tretinoin?

The idea behind skin cycling is to reduce irritation, so if you are already using tretinoin or retinol multiple times a week with no irritation, then there's no need to add in rest days.

When to give up on tretinoin?

Signs you should stop using tretinoin

It's normal to experience some dryness, peeling, and irritation—maybe even some purging—as you adjust to using tretinoin. But if the side effects become severe or don't go away, it might be time to hit pause and give your skin a breather.

How to know if tretinoin is working?

After 4-6 weeks, your skin will get used to Tretinoin and will begin to be noticeably smoother and more even. Depending on how often you use Tretinoin, you may begin to see full benefits by this point. A lot of the initial irritation will settle down and true “retinization” of your skin is in full force.

What are the tretinoin uglies?

Vitamin A can be unstable as an ingredient, and this can mean your skin will become more sensitive. There is often an initial phase when using retinoids for the first time, known by many as the 'retinoid uglies'. Essentially, your skin can see a decline before improvement during an adjustment period.

What is the sandwich method for tretinoin?

Option one: The sandwich technique

After washing your face, apply a layer of moisturiser. Allow it to dry down for 5-10 minutes. Then, apply a pea-sized amount of tretinoin to your entire face. Allow this to dry down for 5-10 minutes.

Does tretinoin peeling ever stop?

Tretinoin skin peeling is usually temporary and only lasts for a few months for most people, meaning patience is normally an effective approach. Use a moisturizer. It's totally okay to use a moisturizer with tretinoin. Apply the moisturizer first before tretinoin if you have skin dryness.

Should I use tretinoin on my neck?

The skin on the neck is thinner and more sensitive, so it may not tolerate tretinoin well, causing irritation. However, if you want to address signs of ageing on your neck, you may benefit from using tretinoin there. To avoid irritation, start with a lower frequency on your neck and build up as your skin tolerates it.

What is the downside of tretinoin?

Topical tretinoin can cause your skin to become dry, red, swollen, blistered, or flaky. It may also cause your skin to itch, be painful, or feel like it is burning. Stop using topical tretinoin and call your healthcare provider if these symptoms become worse or do not go away.

What not to mix with tretinoin?

You may also want to avoid salicylic acid, glycolic acid, and erythromycin gel (Erthygel), as these ingredients and products can cause dryness. Though, your dermatologist can help you decide if combining these products with tretinoin is safe. Tretinoin can also cause sun sensitivity.

Does moisturizer cancel out tretinoin?

However, a 2019 study notes that using tretinoin with a moisturizer can help reduce its potential irritation and drying effects. However, while moisturizers may provide relief, combining other skin products with tretinoin could lead to further skin irritation or damage.

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