What vitamins interact with isotretinoin?

Author: Chanel Gislason  |  Last update: Friday, December 12, 2025

Do not take vitamin A or any vitamin supplement containing vitamin A while using this medicine, unless otherwise directed by your doctor. To do so may increase the chance of side effects. During the first 3 weeks you are taking isotretinoin, your skin may become irritated.

What vitamins should I avoid on Accutane?

1. Vitamin A supplements. Accutane is part of a group of vitamin A-related medications called retinoids. So it's best to avoid taking other products that contain vitamin A while you're taking Accutane.

What Cannot be taken with isotretinoin?

Cautions with other medicines

tetracycline antibiotics such as doxycycline, oxytetracycline, minocycline or lymecycline. vitamin A or supplements containing vitamin A. other acne medicines, including acne medicines applied to the skin (using both together may make skin irritation worse)

Can I take isotretinoin with multivitamins?

Before Treatment Starts

Be sure to tell your doctor if you are taking any other medicines, even over-the-counter medicines. Isotretinoin is like vitamin A, so you should not take vitamin A pills or multivitamins with vitamin A while you are taking isotretinoin.

Can I take vitamin D while on isotretinoin?

Interactions between your drugs

No interactions were found between isotretinoin and Vitamin D3.

Accutane | Roaccutane | Accutane Side Effects | Isotretinoin Helpful Tips

Can I take vitamin C while on isotretinoin?

Interactions between your drugs

No interactions were found between isotretinoin and Vitamin C.

What vitamins does Accutane deplete?

Furthermore, this study demonstrated that after a 6 months treatment, isotretinoin can result in decreases in vitamin B12 and folic acid levels. Supplementation of vitamin B12/folic acid should be recommended in cases of their deficiency in patients under isotretinoin therapy.

What to avoid while on Accutane?

What may interact with this medication?
  • Alcohol.
  • Benzoyl peroxide, salicylic acid, or other drying medications used for acne.
  • Medications for seizures.
  • Orlistat.
  • Other medications that make you more sensitive to the sun such as sulfa medications.
  • Progestin-only birth control hormones.
  • St. John's Wort.

Can I take omega-3 with isotretinoin?

Another randomized controlled trial showed that O3FA supplementation with isotretinoin use resulted in improvements in xerosis and dry lips. No adverse effects were reported in either study.

Can isotretinoin cause weight gain?

"Isotretinoin, as an effective treatment option for acne in standard doses, does not have metabolic side effects such as weight changes, BMI, and other factors related to metabolic diseases like BS levels, triglyceride levels, LDL levels, HDL levels, and so on," according to Bazargan et al.

Is isotretinoin hard on the liver?

There is no known reason why isotretinoin may elevate serum aminotransferase, but high dosages of the drug may have a toxic effect on the liver. However, it is rare for isotretinoin to cause abnormally high results in a liver test, and it is rare for the drug to lead to liver injury.

Can you have dairy with isotretinoin?

They advise avoidance of all dairy products both during and after their treatment with isotretinoin.

How to avoid Accutane purge?

Managing the Purging Phase
  1. Maintain a gentle skincare routine.
  2. Use non-comedogenic products.
  3. Stay hydrated and maintain a balanced diet.
  4. Avoid picking or squeezing blemishes.

How to protect the liver while on Accutane?

It's best to avoid drinking alcohol if you take Accutane. This is because both substances can lead to liver problems, as well as increase certain types of fat in your blood. Liver damage isn't common with Accutane, but it's possible.

What is the greatest side effect of isotretinoin?

Common side effects of Accutane (isotretinoin) include dryness and temporary hair loss. Rare and more serious side effects include depression and psychosis, lipid problems and inflammatory bowel disease (IBD).

Can you take zinc while on isotretinoin?

In this study, oral zinc combined with low-dose isotretinoin resulted in satisfactory improvement in acne vulgaris patients with fewer side effects.

What supplements to avoid on isotretinoin?

Do not take vitamin A or any vitamin supplement containing vitamin A while using this medicine, unless otherwise directed by your doctor. To do so may increase the chance of side effects. During the first 3 weeks you are taking isotretinoin, your skin may become irritated.

What is not allowed when taking isotretinoin?

plan to avoid hair removal by waxing, laser skin treatments, and dermabrasion (surgical smoothing of the skin) while you are taking isotretinoin and for 6 months after your treatment. Isotretinoin increases the risk that you will develop scars from these treatments.

What vitamins to take while on Accutane?

Authors concluded that supplementation with folic acid and vitamin B12 should be considered as a supplemental treatment option for reducing musculoskeletal side effects seen in isotretinoin [30].

What products should not be taken with Accutane?

As Isotretinoin is a retinoid, it should not be used with any other vitamin A or retinol products. Chemical peels, acids or physical exfoliants that resurface the skin should also be avoided as they will create further photo sensitivity, dryness and irritation.

How to stay clear after Accutane?

Since Accutane does the heavy lifting, keep your routine simple: a gentle cleanser, a non-comedogenic moisturizer, and don't forget sunscreen.
  1. Step 1: Gently cleansing milk. ...
  2. Step 2: Non-comedogenic moisturizer. ...
  3. Ingredients to add to your routine. ...
  4. Don't forget your body's skin! ...
  5. A less rich cleanser and moisturizer.

Can I take collagen while on isotretinoin?

Yes, you can take collagen supplements with Isotretinoin.

What vitamin A foods to avoid on Accutane?

Foods high in vitamin A, such as fish, fish oils, cantaloupe, carrots, dark green leafy veggies, sweet potatoes, pumpkins, butternut squash, vitamin A supplements, and supplemented foods should be limited on days when patients take the medication.

How do I maximize my Accutane absorption?

Accutane is soluble in fat but not water. This means that for Accutane to be properly absorbed, it must be taken simultaneously with fat. Otherwise less Accutane will be absorbed and there will be a much greater risk of recurrence of acne in the future.

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