What to use after niacinamide and retinol?

Author: Dr. Myrtis Goyette II  |  Last update: Monday, January 26, 2026

Apply niacinamide in the morning to soothe and strengthen your skin and use retinol at night to promote cell turnover and reduce signs of ageing. Always follow with sunscreen during the day, as retinol increases sun sensitivity.

What order do you apply niacinamide and retinol?

First, use niacinamide and then layer retinol to protect your skin from any irritation. The optimal pH level for retinol activation is between 5.5 and 6 and topical niacinamide is most effective at a pH of 5-7. Neither ingredient will alter the pH of the other and instead work to increase the effectiveness of each.

Can I use moisturizer after niacinamide and retinol?

When using niacinamide and retinol together, it's also important to keep in mind that both ingredients can dry the skin. To avoid dryness or flakiness, it's a good idea to use a moisturizer that contains hydrating ingredients such as hyaluronic acid or glycerine.

Can I use Vitamin C with niacinamide and retinol?

Can you layer vitamin C and niacinamide together? The answer is yes, you can. Vitamin C, niacinamide, hyaluronic acid, then moisturizer, then sunscreen. And you could use niacinamide before. your retinol as well.

Does niacinamide deactivate retinol?

Simply find the best products with retinol and niacinamide included in their formulas and incorporate them into your skin care routine. You should also know, there's no need to wait between applying both ingredients. These ingredients “play well” with others and won't deactivate each other.

TOP 3 MYTHS ABOUT NIACINAMIDE| Dr Dray

What not to pair with niacinamide?

DON'T MIX: AHA/BHA and niacinamide

Niacinamide is used to treat hyperpigmentation and reduce fine lines and wrinkles, while alpha hydroxy acids (AHAs) and beta hydroxy acids (BHAs) are chemical exfoliants. To understand why niacinamide shouldn't be mixed with AHAs and BHAs, you need to consider pH.

Does niacinamide purge retinol?

This can help you experience the benefits of retinol while minimizing the side effects. Niacinamide can also help support the skin barrier, which is crucial in the early stages of retinol use (often called the “purge” period).

What order do you use retinol niacinamide and vitamin C?

If you're applying them together, you should apply Vitamin C first, followed by hyaluronic acid or niacinamide. Don't use it with AHAs, BHAs, and retinol at once. You can use it in low concentrations of AHA and BHA in your routine on alternate nights – Vitamin C one night and retinol the other.

Why can't you use vitamin C and niacinamide together?

The misconception that you shouldn't use niacinamide and vitamin C together originates from outdated studies conducted in the 1960s. These early studies suggested that combining these ingredients could render them ineffective or cause skin irritation due to the instability of vitamin C in certain formulations.

Do I need to exfoliate if I use retinol?

It depends. In many cases, combining retinol and exfoliants can provide faster and better results, especially if you have very specific goals, like reducing breakouts faster or targeting discoloration. However, for simple skin maintenance and age prevention, using a retinoid alone can be more than enough.

What order does niacinamide go in?

It's suitable for all skin types and fits easily into your existing skincare routine. As for when to use niacinamide serum, we typically recommend applying products in order of consistency. That means your serum should come after toner, but before richer lotions or creams.

How long to let retinol sit before moisturizer?

After applying your retinol product, it's best to wait roughly 10 minutes before moving on to the next step in your routine.

Is niacinamide or retinol better for hyperpigmentation?

Niacinamide and retinol are popular skin care ingredients that can treat acne, hyperpigmentation, and signs of aging. While they have similar effects, retinol is more potent. However, it may also cause more significant side effects. It is possible to use the ingredients alone or in combination.

What is the gap between niacinamide and retinol?

Apply Niacinamide to your entire face (be it serum or cream/moisturiser), wait for 25 to 30 minutes and then apply Retinol. The next day, make sure to apply a broad-spectrum sunscreen.

How to layer snail mucin, niacinamide, and retinol?

In this case, you'd apply first Snail Mucin, followed by Niacinamide & finally Azelaic Acid 💦 like that, you will be able to hydrate your skin, boost your collagen production, as well as brightening your pigmentation or even calming redness 🫶🏼 This recommendation can go for either morning or night routines 💕

When to use niacinamide, morning or night?

Should You Use Niacinamide In the AM Or PM? Niacinamide is recommended to be applied up to two times per day. Given this advice, it is typically applied once in the AM and again in the PM before bed. Unlike retinol, niacinamide doesn't increase skin sensitivity and higher chance of reactions from the sun.

Do and don'ts niacinamide?

Don't use it with exfoliating ingredients: Niacinamide can increase skin sensitivity, so it's best to avoid using it with exfoliating ingredients such as salicylic acid and glycolic acid. Don't use it if you have an allergy: Niacinamide, like any other skincare ingredient, can cause allergic reactions in some people.

What moisturizer to use after niacinamide?

Consider pairing your niacinamide face serum with hyaluronic acid for an enhanced skincare regimen. Combining niacinamide with hyaluronic acid can brighten, hydrate, and plump up your skin. Apply niacinamide serum on a cleansed skin and let it absorb. After a few seconds, follow up with hyaluronic acid face serum.

Do you put retinol or niacinamide first?

It is not unusual to find a combination of niacinamide and retinol in a single skincare product, but you can use niacinamide and retinol as separate steps in a consistent routine. If you're using separate products, it is recommended that you apply retinol first then move forward with niacinamide application.

Can I use vitamin C in the morning and retinol and niacinamide at night?

“It's definitely a good idea to use both of these ingredients in your regular skincare routine,” says Dr. Engelman. Just remember to choose formulas that are right for your skin type and skin concerns and to use your vitamin C in the morning (with SPF, of course) and your retinol in the evening before bed.

What to pair with niacinamide?

Check out the list of ingredients that positively combine with niacinamide to benefit your skin effectively:
  • Niacinamide and vitamin C. ...
  • Niacinamide and retinol. ...
  • Niacinamide and salicylic acid. ...
  • Niacinamide and hyaluronic acid. ...
  • Niacinamide and Centella Asiatica.

Can I use niacinamide every day?

It's an ingredient found in a number of moisturizing skin-care products as well as in certain foods and supplements like multivitamins. Can you use niacinamide every day? Yes. In fact, you can use niacinamide-containing topical products in the morning and night because it's generally a gentle ingredient.

How long after retinol to apply moisturizer?

Wait: Allow the retinol to absorb into your skin. Waiting 20-30 minutes can reduce the risk of irritation. Moisturize: Apply your moisturizer to lock in hydration and soothe the skin.

What not to use with retinol and niacinamide?

Niacinamide and AHAs / BHAs

Similar to retinol, niacinamide should not be used with acidic skincare ingredients like alpha hydroxy acids and beta hydroxy acids. Ordinary niacinamide combined with an acid can cause a bad chemical reaction of redness and flushing.

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