Many influencers and podcasters are pushing the supplement - claiming NAD, which stands for nicotinamide adenine dinucleotide, can turn back the clock on aging - boosting energy, sharpness and strength. Preliminary research shows promise, but will it really work?
Our Fountain of Youth formula uses our Anti-Aging formula as a base, which is a blend of antioxidants with an addition of Glutathione and a multitrace, of zinc, copper, manganese, chromium and selenium.
Recently, that work has centered on metformin, the world's most-prescribed diabetes drug. Scientists have thought the medication might also change how healthy people age. Experiments suggested that in addition to reducing blood sugar, it can cut inflammation and produce other beneficial cellular changes.
In theory, these supplements could slow the effects of aging and combat diseases, but more research is needed. Without strong clinical trials in humans, informed decisions cannot be made about the risks versus benefits of various NAD+ supplements.
“Like many other supplements there is risk for mild side effects, particularly GI-related issues such as nausea, diarrhea, and vomiting. Given their role in cell processes, there could be downstream effects in cell metabolism that we just don't know about yet,” Hokeness says.
There is also controversy about the involvement of NAD+ in the activation of PARPs and sirtuins in carcinogenesis and inflammation/sepsis. Elevated NAD+ levels may have different roles in different stages of sepsis.
"Metformin, however, can cause lactic acidosis in conditions where lactic acid production is high and the disposal of lactic acid is reduced. In conditions such as circulatory failure, sepsis, and anoxia or hypoxia, metformin use may result in lactic acidosis and should be avoided.
This is because metformin can build up in the body if your kidneys aren't able to get rid of it properly. Other health conditions, such as liver disease and heart failure, can also increase your risk of lactic acidosis, a potentially severe but rare metformin side effect.
Metformin treatment brought about a significant reduction of visceral fat mass compared to controls accompanied by an up-regulation of fat oxidation-related enzyme in the liver, UCP-1 in the brown adipose tissue and UCP-3 in the skeletal muscle.
Vitamin E
Vitamin E promotes collagen production, prevents its breakdown, increases water retention, and protects the skin from oxidative stress. Regular use of products with this vitamin helps tighten the skin and provides other rejuvenating effects.
Similar to metformin, emerging evidence shows that berberine could be another AMPK activator that regulate both ROS and mTOR/rpS6 pathways, and thereby have the potential to enhance health [77]. AMPK activator metformin and berberine are reported to extend life span of C.
Three main strategies to counteract the aging-related decline of NAD could represent the possible fountain of youth, not only for the oocyte, such as avoiding/minimizing NAD degradation, supplementing NAD precursors, and activating NAD biosynthetic enzymes [1,2].
Even though metformin may lead to some weight loss, the amount you lose may be far less than expected. On average, weight loss after one year on the drug is only six pounds, according to past research.
Nonsteroidal anti-inflammatory drugs (NSAIDs), diuretics, and angiotensin-converting enzyme (ACE) inhibitors are all drugs that can cause kidney damage. Certain medications administered in hospital settings, such as aminoglycoside antibiotics and vancomycin, can also damage the kidneys.
Dapagliflozin is mainly used to treat type 2 diabetes. It can also be used to treat heart failure and chronic kidney disease (CKD). Dapagliflozin is usually prescribed if: you have type 2 diabetes and cannot take metformin.
“Because the metformin helps your cells absorb sugar like they should, I've noticed an increase in energy and the ability to actually feel satisfied and not want to snack so much because my body's utilizing sugar like it should,” Steve says.
This directly infers those higher levels of NAD may cause tumors to be more potent. In this event, starving cancer of NAD and from the enzymes found in the myriad of NAD pathways may also hold merit in the fight against slowing further cancer progression.
That is why celebrities like Kendall Jenner and Hailey Bieber discuss enjoying services such as NAD+ Therapy as a core component of their self-care routines and it is even reported that Justin Bieber has been sleeping in a Hyperbaric Oxygen Chamber to combat his chronic health issues.