What should you not pair with hyaluronic acid?

Author: Prof. Garland Crooks  |  Last update: Saturday, March 22, 2025

Niacinamide and Salicylic Acid: Niacinamide is a popular skincare ingredient that can help minimize pores and improve skin texture. Salicylic acid, on the other hand, is often used to treat acne. While both ingredients have their own benefits, using them together with hyaluronic acid may cause irritation or dryness.

What should not mix with hyaluronic acid?

For instance, Alpha Hydroxy Acids (AHAs), such as Lactic Acid and Glycolic Acid, and Synthetic Retinol are a pair that can easily cause irritation.

Does hyaluronic acid clash with anything?

Some active ingredients such as retinol and vitamin C can irritate the skin if used in conjunction with exfoliants such as acids, while more gentle humectants such as hyaluronic acid can make a harmonious pairing with just about everything.

What does hyaluronic acid conflict with?

Hyaluronic Acid and Derivatives have no noted serious interactions with any other drugs. Hyaluronic Acid and Derivatives have no noted severe interactions with any other drugs.

What is hyaluronic acid compatible with?

Hyaluronic Acid and Ceramides

In fact, they work even harder for your skin once combined! While ceramides help minimise water lost through the skin's surface, hyaluronic acid draws water molecules back in from the atmosphere to keep the barrier juicy and replenished. Pumped Up Skin, right this way.

Doctor V - Hyaluronic Acid, Mistakes You Are Making | Skin Of Colour | Brown Or Black Skin

Who should avoid hyaluronic acid?

However, people who have a history of severe allergic reactions, such as anaphylaxis, should be cautious when using hyaluronic acid. Its effects during pregnancy and while breastfeeding remain unknown, so women may want to avoid taking hyaluronic acid supplements during these times.

What compliments hyaluronic acid?

What Ingredients Does Hyaluronic Acid Pair Well With?
  • Vitamin C. Yes, these two superstars can give your skin a super anti-ageing boost with Hyaluronic Acid's plumping and hydrating qualities along with Vitamin C's antioxidant and brightening properties. ...
  • Ceramides. ...
  • Retinol. ...
  • Panthenol. ...
  • AHAs & BHAs.

When should you not use hyaluronic acid?

If you are receiving radiation therapy, don't use hyaluronic acid on your skin. Hardening of skin and connective tissue (scleroderma): Applying hyaluronic acid to the skin might make skin ulcers worse in people who have a condition called scleroderma. If you have scleroderma, don't use hyaluronic acid on your skin.

What not to mix with peptides?

For that reason, mixing peptides and glycolic acid is not recommended. Why shouldn't these acids be mixed with peptides? The reason peptides and salicylic acid as well as peptides and glycolic acid aren't efficacious ingredient combinations is because peptides are susceptible to hydrolysis when exposed to acids.

Which serums cannot be used together?

Skincare ingredients not to mix
  • Retinoids or retinol and benzoyl peroxide. ...
  • Retinoids or retinol and vitamin C. ...
  • Retinoids or retinol and salicylic acid. ...
  • Retinoid or retinol and AHAs/BHAs. ...
  • Vitamin C and AHAs/BHAs. ...
  • Vitamin C and benzoyl peroxide. ...
  • Niacinamide and AHAs / BHAs. ...
  • Benzoyl peroxide and hydroquinone.

What is the rule of hyaluronic acid?

The Only Rule for Hyaluronic Acid? Always Apply It on Damp Skin! It might sound surprising, but when hyaluronic acid is applied to dry skin, it can have the opposite effect, leaving your skin even more dehydrated.

Can I mix retinol with hyaluronic acid?

So, if you are looking for an answer to “Can you use retinol and hyaluronic acid together? The answer is yes. The combination of these two ingredients can help you treat multiple skin concerns and give you a more youthful, radiant complexion.

Can I use vitamin C and hyaluronic acid together?

While vitamin C and hyaluronic acid can be used separately for impressive outcomes, they are also a power duo when applied in tandem. In fact, vitamin C and hyaluronic acid are often mixed - either in one serum formula, or layered in a skincare regime.

What is best combined with hyaluronic acid?

For smoother-looking skin, pair Retinaldehyde and Hyaluronic Acid. For clearer-looking skin, pair Salicylic Acid and Niacinamide 10% + Zinc 1%. For hydrated skin, pair Hyaluronic Acid and Niacinamide.

What medications does hyaluronic acid interact with?

Medications known to interact with hyaluronan
  • benzalkonium chloride topical.
  • cetylpyridinium topical.
  • COVID-19 mRNA (Moderna) vaccine.
  • COVID-19 mRNA (Pfizer) vaccine.
  • sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 308)
  • sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 309)
  • sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 310)

What are the restrictions of hyaluronic acid?

You may receive between one and five injections, usually a week apart, depending on which brand of hyaluronic acid your healthcare professional uses. For at least two days after the injection, you should avoid jogging, high-impact sports or being overly active.

What not to mix with hyaluronic acid?

However, there are certain ingredients that should not be mixed with hyaluronic acid:
  • AHAs and BHAs: AHAs (alpha hydroxy acids) and BHAs (beta hydroxy acids) are chemical exfoliants that can help improve skin texture and unclog pores. ...
  • Benzoyl Peroxide: Benzoyl peroxide is a common ingredient found in acne treatments.

What peptide is best for tightening skin?

The best peptides to improve skin appearance and overall health include: GHK-Gu: This anti-wrinkle peptide helps tighten the skin and reduce the appearance of age-related lines, folds, and loose patches.

What is best paired with peptides?

Ingredients that Enhance Peptide Benefits
  • Vitamin C. Topical vitamin C is a powerful antioxidant, a cofactor for collagen production, and a brightening agent known for fading areas of hyperpigmentation. ...
  • Retinol. ...
  • Glycolic Acid. ...
  • Salicylic Acid. ...
  • Lactic Acid.

Is there a downside to hyaluronic acid?

The most common adverse effects associated with hyaluronic acid filler are pain, bruising, redness, itching, and swelling. These side effects are self-limited and typically last no more than seven days.

Is hyaluronic acid hard on the liver?

10. Is Hyaluronic Acid Bad For Your Liver? In the case of patients with liver diseases, it is advised to avoid using HA as the increased levels of HA in the bloodstream can cause thrombosis. Hence, user discretion and medical supervision are advised.

What happens if you use hyaluronic acid everyday?

What does hyaluronic acid do for skin? Long-term use of hyaluronic acid serum on your skin or in a supplement taken by mouth can improve overall skin health. It's also great for helping improve overall skin flexibility and elasticity (meaning it makes your skin more stretchy and soft).

What is the best routine with hyaluronic acid?

Use a moisturizer containing hyaluronic acid twice daily to access the best effects. These products should be used after you have cleansed your skin. If your routine also includes applying serums and exfoliating, apply your moisturizer after these steps.

What not to pair with niacinamide?

DON'T MIX: AHA/BHA and niacinamide

Niacinamide is used to treat hyperpigmentation and reduce fine lines and wrinkles, while alpha hydroxy acids (AHAs) and beta hydroxy acids (BHAs) are chemical exfoliants. To understand why niacinamide shouldn't be mixed with AHAs and BHAs, you need to consider pH.

What moisturizer is good after hyaluronic acid?

Look for moisturizers with additional hydrating ingredients like glycerin, ceramides, or squalane to enhance the benefits of hyaluronic acid and keep your skin looking and feeling its best.

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