What should you never mix niacinamide with?

Author: Axel Stiedemann  |  Last update: Friday, April 25, 2025

DON'T MIX: AHA/BHA and niacinamide Niacinamide is used to treat hyperpigmentation and reduce fine lines and wrinkles, while alpha hydroxy acids (AHAs) and beta hydroxy acids (BHAs) are chemical exfoliants. To understand why niacinamide shouldn't be mixed with AHAs and BHAs, you need to consider pH.

What can you not pair with niacinamide?

Niacinamide generally works well with most products, but it's best not to combine it with vitamin C (ascorbic acid) in the same routine as it can cause irritation. Additionally, avoid using it with strong exfoliants or retinoids in high concentrations to prevent skin sensitivity. For more, check out my Quora Profile.

What does niacinamide react badly with?

Niacinamide works well with other skincare ingredients, including retinol and hyaluronic acid. However, some ingredients, like vitamin C, may interact negatively with niacinamide. Therefore, it's recommended to use products containing these ingredients at different times of the day or on alternate days.

Can I mix niacinamide with everything?

Niacinamide can be used together with anything. In fact it's a great skin barrier-supporting ingredient when paired together with actives like chemical exfoliants. I use them in the same routine.

Does niacinamide interact with anything?

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with NIACINAMIDE. Niacinamide might slow blood clotting. Taking niacinamide along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

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What cancels out niacinamide?

Niacinamide and vitamin C

This combination sparks a lot of debate among skincare experts. Some say that since both niacinamide and vitamin C contain antioxidants, they cancel each other out and might even lead to irritation.

Do and don'ts niacinamide?

Don't use it with exfoliating ingredients: Niacinamide can increase skin sensitivity, so it's best to avoid using it with exfoliating ingredients such as salicylic acid and glycolic acid. Don't use it if you have an allergy: Niacinamide, like any other skincare ingredient, can cause allergic reactions in some people.

What is the best combination with niacinamide?

Niacinamide + salicylic acid is what you need in your skincare routine. Salicylic acid is best known for its deep-cleansing properties and deep-penetrating action to unclog pores and slough off dead and dry skin. The antibacterial and anti-inflammatory properties of salicylic acid help clear away pustules and papules.

Can you overuse niacinamide?

Additionally, such flare-ups can happen due to incorrect layering of ingredients. Remember, Niacinamide goes in the end (before moisturizer) to help alleviate inflammation, redness, or irritation. More product doesn't guarantee better results. Instead, overusing Niacinamide may lead to skin sensitivities and flare-ups.

What skincare should not be mixed?

Retinoids don't combine well with AHAs, benzoyl peroxide, salicylic acid, or vitamin C due to potential stability issues and skin sensitivities, and soap-based cleansers can also reduce vitamin C's skin benefits.

What conflicts with niacinamide?

Take for example Vitamin C and Niacinamide - two active ingredients we don't recommend using together in the same routine. The key word here is routine. You can use Niacinamide 10% + Zinc 1% in the AM routine and Ascorbyl Glucoside Solution 12% in the PM routine -- just not together in the morning or evening.

How to know if niacinamide is working?

Niacinamide and hyaluronic acid

While you may not see any significant results during the first few weeks, there should be a notable difference by about 4 weeks. After 8 weeks, you should notice more hydrated, smoother, and toned skin.

Why is niacinamide not recommended?

Safe but not totally for people with sensitive skin. As mentioned above, niacinamide seems to have an irritating effect when used with concentration formulas. Redness and itching are some of the common reactions. Although these are rare issues, they may still cause a great impact on someone's skin health.

Which acid Cannot be used with niacinamide?

There are several active ingredients that can be paired together and are beneficial for your skin. However, glycolic acid and niacinamide cannot be used together at the same time. This is because mixing these two ingredients can make these acids less effective.

What moisturizer to use after niacinamide?

Consider pairing your niacinamide face serum with hyaluronic acid for an enhanced skincare regimen. Combining niacinamide with hyaluronic acid can brighten, hydrate, and plump up your skin. Apply niacinamide serum on a cleansed skin and let it absorb. After a few seconds, follow up with hyaluronic acid face serum.

Why is my skin getting darker after using niacinamide?

Some may also have skin discoloration due to using niacinamide combined with other active ingredients that are too harsh for your skin type. Niacinamide can also cause problems when it's mixed with the following substances: Acids, including lactic acid, glycolic acid, and azelaic acid.

Is 10% niacinamide too strong for skin?

Now, most people can tolerate niacinamide well even at 10% twice daily. But if you have a mysterious skin rash or unexplained irritation, it could be time to take a closer look at your niacinamide levels. One of the biggest issues of overdoing niacinamide isn't necessarily the one 10% product you may have.

How long will my skin purge from niacinamide?

Purging should end if the breakouts last longer than these 6 weeks. Purging usually occurs when you start a new skincare product that accelerates the turnover rate of your skin cells. The most common culprits behind purging are acids (AHA, BHA), retinoids, vitamin C, or even niacinamide.

What not to pair with niacinamide?

DON'T MIX: AHA/BHA and niacinamide

Niacinamide is used to treat hyperpigmentation and reduce fine lines and wrinkles, while alpha hydroxy acids (AHAs) and beta hydroxy acids (BHAs) are chemical exfoliants. To understand why niacinamide shouldn't be mixed with AHAs and BHAs, you need to consider pH.

What to layer niacinamide with?

You can (and should) consider layering niacinamide and retinol in the same routine, especially if you have sensitive skin. Retinol is a well-known ingredient that helps reduce the appearance of fine lines, wrinkles and other signs of aging.

What are the side effects of using niacinamide on your face?

What are the side effects of Niacinamide? Topical application is completely safe and may not cause any skin problems for a healthy person. People with sensitive skin may face mild redness, itching, or a burning sensation. Stomach upset.

Which skin products are not to mix?

Retinol: As Retinol and Salicylic Acid are both exfoliating, drying skincare ingredients, using both together in the same routine could lead to serious irritation. Glycolic Acid: Similarly, as an AHA, Glycolic Acid helps exfoliate the top layer of the skin, which is too intense when used alongside Salicylic Acid.

Can I use 10% niacinamide every day?

Dr. Henry says that it's typically okay to use niacinamide twice a day (in the morning and in the evening), but advises that more than that could be excessive. As with any skincare ingredient, pay attention to its effect on your complexion to determine if you need to change its use in your regimen.

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