What products not to mix with niacinamide?

Author: Zander Klocko  |  Last update: Saturday, June 21, 2025

DON'T MIX: AHA/BHA and niacinamide Niacinamide is used to treat hyperpigmentation and reduce fine lines and wrinkles, while alpha hydroxy acids (AHAs) and beta hydroxy acids (BHAs) are chemical exfoliants. To understand why niacinamide shouldn't be mixed with AHAs and BHAs, you need to consider pH.

What cannot be mixed with niacinamide?

Niacinamide generally works well with most products, but it's best not to combine it with vitamin C (ascorbic acid) in the same routine as it can cause irritation. Additionally, avoid using it with strong exfoliants or retinoids in high concentrations to prevent skin sensitivity. For more, check out my Quora Profile.

What reacts badly with niacinamide?

Niacinamide works well with other skincare ingredients, including retinol and hyaluronic acid. However, some ingredients, like vitamin C, may interact negatively with niacinamide. Therefore, it's recommended to use products containing these ingredients at different times of the day or on alternate days.

Does niacinamide interact with anything?

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with NIACINAMIDE. Niacinamide might slow blood clotting. Taking niacinamide along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

What conflicts with niacinamide?

Take for example Vitamin C and Niacinamide - two active ingredients we don't recommend using together in the same routine. The key word here is routine. You can use Niacinamide 10% + Zinc 1% in the AM routine and Ascorbyl Glucoside Solution 12% in the PM routine -- just not together in the morning or evening.

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What cancels out niacinamide?

Niacinamide and vitamin C

This combination sparks a lot of debate among skincare experts. Some say that since both niacinamide and vitamin C contain antioxidants, they cancel each other out and might even lead to irritation.

What to avoid when using niacinamide?

Don't use vitamin C: Niacinamide and vitamin C can cause skin irritation and discoloration when used together, so it's best to use them at different times of the day. Don't overuse: While niacinamide is generally well-tolerated, overusing it can cause redness and irritation, especially in people with sensitive skin.

What is the best combination with niacinamide?

Niacinamide + salicylic acid is what you need in your skincare routine. Salicylic acid is best known for its deep-cleansing properties and deep-penetrating action to unclog pores and slough off dead and dry skin. The antibacterial and anti-inflammatory properties of salicylic acid help clear away pustules and papules.

Is it OK to use multiple products with niacinamide?

It's always advisable to apply leave-on Niacinamide products like toners, serums, moisturisers, etc., twice a day. Bear in mind that you can have more than one Niacinamide product in your skincare routine. After cleaning and drying your skin, you can apply a Niacinamide toner, then a Niacinamide serum, or a face cream.

Who should not use niacinamide on face?

Safe but not totally for people with sensitive skin. As mentioned above, niacinamide seems to have an irritating effect when used with concentration formulas. Redness and itching are some of the common reactions. Although these are rare issues, they may still cause a great impact on someone's skin health.

Why does my skin look worse after using niacinamide?

You might be experiencing breakouts if your skin is too sensitive to niacinamide or if you are using it in combination with other irritating products. These breakouts could be new pimples, redness, and inflammation in areas where you do not normally get acne.

What moisturizer to use after niacinamide?

Consider pairing your niacinamide face serum with hyaluronic acid for an enhanced skincare regimen. Combining niacinamide with hyaluronic acid can brighten, hydrate, and plump up your skin. Apply niacinamide serum on a cleansed skin and let it absorb. After a few seconds, follow up with hyaluronic acid face serum.

Why is my skin getting darker after using niacinamide?

Some may also have skin discoloration due to using niacinamide combined with other active ingredients that are too harsh for your skin type. Niacinamide can also cause problems when it's mixed with the following substances: Acids, including lactic acid, glycolic acid, and azelaic acid.

What deactivates niacinamide?

Vitamin C (L-Ascorbic Acid):
  • Why? Combining niacinamide with pure Vitamin C can destabilize both ingredients, potentially reducing their effectiveness.
  • Best Approach: Use them at different times of the day (Vitamin C in the morning, niacinamide at night).

Which serums are not to use together?

PRODUCT COMBINATIONS THAT DON'T WORK TOGETHER
  • RETINOL SERUM + VITAMIN C. ...
  • RETINOL SERUM + AHAS/BHAS. ...
  • AHAS/BHAS + VITAMIN C. ...
  • NIACINAMIDE SERUM + VITAMIN C. ...
  • TRANEXAMIC ACID. ...
  • SALICYLIC ACID SCALP TREATMENT + GLYCOLIC ACID SCALP TREATMENT. ...
  • PRESCRIBED/OTHER ACTIVES TREATMENTS. ...
  • HYALURONIC ACID SERUM + RETINOL/AHAs/BHAs.

Which acid cannot be used with niacinamide?

There are several active ingredients that can be paired together and are beneficial for your skin. However, glycolic acid and niacinamide cannot be used together at the same time. This is because mixing these two ingredients can make these acids less effective.

What should you never mix niacinamide with?

DON'T MIX: AHA/BHA and niacinamide

Niacinamide is used to treat hyperpigmentation and reduce fine lines and wrinkles, while alpha hydroxy acids (AHAs) and beta hydroxy acids (BHAs) are chemical exfoliants. To understand why niacinamide shouldn't be mixed with AHAs and BHAs, you need to consider pH.

What can you layer niacinamide with?

You can combine niacinamide with all other serums and creams. For example vitamin c serum with niacinamide works wonders for the skin. You can also use it with retinol, Hyaluronic acid, BHAs, or AHAs. Niacinamide and retinol work well together.

Is 10% niacinamide too much?

For general skin tone correction, a niacinamide concentration between 4-5% is often effective and well-tolerated by most individuals. For those looking to tackle more pronounced hyperpigmentation, a higher concentration of 10% may be beneficial, though it's important to monitor the skin for any signs of irritation.

What is the best pair with the ordinary niacinamide?

For smoother-looking skin, pair Retinaldehyde and Hyaluronic Acid. For clearer-looking skin, pair Salicylic Acid and Niacinamide 10% + Zinc 1%. For hydrated skin, pair Hyaluronic Acid and Niacinamide.

How to use niacinamide for best results?

In general, you'll want to apply niacinamide serum to a freshly washed face before using moisturizers or sunscreen. Plus, give each product time to absorb in the skin before applying another. Of course, if you see signs of skin irritation after trying niacinamide, stop its use and consult a medical professional.

Can I mix niacinamide with everything?

While niacinamide plays well with most ingredients, there are some you should avoid pairing it with. For example, mixing niacinamide with acidic ingredients like glycolic or lactic acid can cause flushing and potential irritation.

Which skin products are not to mix?

Retinoids don't combine well with AHAs, benzoyl peroxide, salicylic acid, or vitamin C due to potential stability issues and skin sensitivities, and soap-based cleansers can also reduce vitamin C's skin benefits.

What depletes niacinamide?

Niacin deficiency is more likely to be caused by problems that affect the absorption of niacin or tryptophan. The most common cause is alcoholism. Other possible causes include disorders of the digestive system and prolonged treatment with the tuberculosis drug isoniazid (Laniazid, Nydrazid).

What are the disadvantages of niacinamide on face?

What are the side effects of Niacinamide? Topical application is completely safe and may not cause any skin problems for a healthy person. People with sensitive skin may face mild redness, itching, or a burning sensation. Stomach upset.

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