Benzoyl peroxide and hydroquinone These are two ingredients you should never mix or you run a serious risk of staining your skin and causing some major irritation [7].
In terms of drug interactions, Hydroquinone can react badly with certain products including peroxides (found in hair products and some acne treatments), resorcinol, phenol, and salicylic acid. Using Hydroquinone with these products may cause temporary staining of the skin.
Enhanced skin-lightening effects: Hydroquinone is a powerful skin-lightening agent that can effectively fade dark spots and patches. The lightening effects may be enhanced when combined with azelaic acid, which has also been shown to improve skin tone.
2.2. 2 Oxidation of hydroquinone Hydroquinone is oxidized by a variety of oxidants including nitric acid, halogens, persulfates and metal salts (NIOSH, 1978). It is also oxidized by molecular oxygen in alkaline solutions. Hydroquinone reacts with molecular oxygen (autooxidation).
A major key to hydroquinone is short-term use. You can slather it on twice daily for at least six weeks (and no more than six months). After one to three months, you should start to see your hyperpigmentation fade away.
Combination Tip: Combining hydroquinone with Vitamin C may improve overall efficacy, but due to potential sensitivities, this combination should only be used under the supervision of a dermatologist. Sunscreen: How It Works: Sunscreen is essential for preventing further hyperpigmentation caused by UV exposure.
However, medical guidelines specify that you should stop using hydroquinone if you haven't seen any results after about three months. Your doctor may recommend you try some new products that combine hydroquinone with other ingredients, such as glycolic acid.
According to research, ochranonsis is a condition that might occur following long-term application of skin-lightening creams containing hydroquinone. Ochranosis may cause darkening of the skin, instead of fading a particular spot. Long-term use of Hydroquinone creams may also lead to exogenous ochronotic lesions.
Alternative lightening agents including mequinol, arbutin, kojic acid, and others have shown comparable efficacy to hydroquinone in treating hyperpigmentation with less concerning side effects.
Using a 4% hydroquinone skin care system plus 1.0% retinol cream to treat mild-to-moderate melasma can significantly reduce melasma severity and pigmentation intensity within four weeks. In addition, this combination treatment can significantly improve all aspects of photodamage, including coarse wrinkling.
Conclusion. A cream formula containing 4% hydroquinone + 10% glycolic acid + 0.01% hyaluronic acid was very effective in treatment of melasma with tolerable side effects. Dermoscope is a valuable noninvasive tool in the diagnosis and follow-up of melasma treatment.
Arbutin has been found to be the most effective active ingredient in our study, even more so than hydroquinone, despite being a naturally occurring derivative.
Tri-Luma (fluocinolone/hydroquinone/tretinoin) - Uses, Side Effects, and More. Overview: Tri-Luma is used to treat a condition called melasma, which is where colored areas appear on the face. Tri-Luma contains three medicines.
You may see results faster if you use tretinoin alongside hydroquinone, azelaic acid, tranexamic acid or kojic acid. Remember to consult a dermatologist when combining different ingredients.
The hydrogen peroxide decomposes and the hydroquinone reacts to form benzoquinone (C6H4O2). The resultant hydrogen reacts with the oxygen to produce water.
Glycolic acid has now become one of the most recommended skincare ingredients for hyperpigmentation, dark spots, and dullness treatment. If you are in search of the best serum for hyperpigmentation, you can choose the one that comes with glycolic acid.
However, 4% Hydroquinone is a better topical hypopigmenting agent with rapid rate of clinical improvement when compared to 0.75% Kojic Acid cream. The side effects of both the hypopigmenting agents were not significant.
Tretinoin is an anti-aging powerhouse, meaning it should have no problem dispatching fine lines and wrinkles. It does not work for deeper wrinkles. Hydroquinone doesn't work at all against fine lines and wrinkles, so stick to the collagen-boosting power of tretinoin.
To maintain the desired affect, hydroquinone should be used concurrently with a strong sunscreen. Many preparations are available as a combination product. Lightening of the skin should be noticed within 4 weeks of initiation, if no change is seen in 3 months, contact your dermatologist for further recommendations.
Rarely ochronosis - ochronosis is a blue-black or gray-blue discoloration; it is rare and more commonly seen in patients that use a high concentration of hydroquinone for a long period on large areas of the body.
While oral consumption probably is not related to topical application, hydroquinone remains controversial because it actually is toxic to melanocytes. Hydroquinone, a phenolic compound chemically known as 1,4 dihydroxybenzene, functions by inhibiting the enzymatic oxidation of tyrosine and phenol oxidases.