Lupus: If you have lupus, you may develop a rash on your nose and cheeks after sun exposure. Addison's disease: It causes patches of dark skin around skin folds or joints.
Cells called melanocytes located in the skin, produce melanin. Melanin gives the skin its color. In certain conditions melanocytes can become abnormal and cause an excessive amount of darkening in the color of the skin. Hyperpigmented concentric rings over the tibia are secondary to prior inflammation.
Overview. Tinea versicolor is a common fungal infection of the skin. The fungus interferes with the normal pigmentation of the skin, resulting in small, discolored patches. These patches may be lighter or darker in color than the surrounding skin and most commonly affect the trunk and shoulders.
The hyperpigmentation related to vitamin B12 deficiency is more common in darker-skinned patients. Few other cases of skin hyperpigmentation due to vitamin B12 deficiency have been reported in the literature. The mechanism of hyperpigmentation is due to increased melanin synthesis rather than a defect in melanin.
Pigmented basal cell cancers have dark areas, often brown, blue or grey in colour.
Your skin can develop darker patches as the result of excess melanin production, typically caused by skin inflammation, hormone fluctuations, and poor lifestyle choices. Age spots – also known as sun spots and liver spots – can also be signs of skin conditions, such as Melasma.
The main sign of acanthosis nigricans is dark, thick, velvety skin in body folds and creases. It often appears in the armpits, groin and back of the neck. It develops slowly. The affected skin might be itchy, have an odor and develop skin tags.
Estrogen and progesterone are two of the major factors responsible for catamenial hyperpigmentation of the skin.
Subacute Cutaneous Lupus Erythematosus (SCLE)
The rash does not normally cause scarring, though can cause considerable darkening or lightening of parts of the skin. These skin changes can be avoided or made less severe by using sun protection.
Vitiligo is a chronic (long-lasting) autoimmune disorder that causes patches of skin to lose pigment or color. This happens when melanocytes – skin cells that make pigment – are attacked and destroyed, causing the skin to turn a milky-white color.
Symptoms of Addison's disease include: Steadily worsening fatigue (most common symptom). Patches of dark skin (hyperpigmentation), especially around scars and skin creases and on your gums.
The incidence of this change varies, and depends on the type of medication involved. Some of the most common drugs involved are NSAIDs, antimalarials, psychotropic drugs, Amiodarone, cytotoxic drugs, tetracyclines, and heavy metals such as silver and gold (which must be ingested, not just worn).
In rare instances, this condition can be found in areas other than skin folds, such as extensor surfaces of the fingers. Acanthosis nigricans can be confused with physiologic hyperpigmentation or lichen simplex chronicus in some patients.
It is often associated with obesity and insulin resistance. When your doctor or nurse did your exam, they pointed out a dark skin patch on your neck, armpit, under the breast or a skin crease. This dark patch is called acanthosis nigricans (AAY-can-THO-sis NIG-ruh-cans), or AN.
When acanthosis nigricans develops in people who are not overweight, a medical work-up should be done. Rarely acanthosis nigricans is associated with a tumor, most commonly of the stomach or gut.
Causes of hyperpigmentation include: Skin inflammation (post-inflammatory hyperpigmentation) Use of certain drugs (such as minocycline, certain cancer chemotherapies, and birth control pills) Hormone system diseases such as Addison disease.
Numerous variables, such as sun exposure, hormone changes, post-inflammatory hyperpigmentation, ageing, skin conditions, and lifestyle choices, can cause skin darkening. Understanding the underlying reasons will help us avoid or cure darker skin tones.
According to the American Academy of Dermatology (AAD), the skin in people with kidney failure may become: pale. gray.
“If it affects the skin, it usually occurs very late in the course of the disease in a limited area of the skin,” he said. A multiple myeloma rash can present in different forms, such as redness, bumps, blisters, or lesions on the skin. Depending on the cause, these rashes may or may not be itchy.