Tretinoin is used to treat acne or other skin diseases as determined by your doctor. It works partly by keeping skin pores clear. One of the tretinoin creams is used to treat fine wrinkles, dark spots, or rough skin on the face caused by the damaging rays of the sun.
Scientific studies showed that tretinoin 0.05 percent gel used daily over a period of 12 weeks reduced levels of acne on the face. Other studies show that daily use of tretinoin cream can make wrinkles and other signs of facial skin aging less obvious.
Tretinoin strength studies
Later studies evaluated Tretinoin 0.05%. While both were equally effective over a one year period, Tretinoin 0.1% was able to achieve cosmetic improvement in 6 months while 0.05% required closer to 12 months.
You may notice tretinoin starting to work within 2 to 3 weeks, but it can take 6 weeks or more to experience the full benefit. If you don't see improvement within 12 weeks, or if you have significant improvement and wonder if you should start using it less frequently, talk to your doctor.
To use the cream, gel, or lotion form of this medicine: Apply just enough medicine to very lightly cover the affected areas, and rub in gently but well. A pea-sized amount is enough to cover the whole face. You may need to use a moisturizer while you are using the lotion.
If you stop using the medication or are inconsistent with your treatment, any improvements you see may disappear over time. Always use the product as prescribed by your healthcare provider (Rodan, 2016).
Generally, it is fine to use tretinoin every night, but you may not want to because of the initial side effects, especially when you first start. You should only use tretinoin as prescribed to avoid significant skin irritation, redness, and other side effects.
Tretinoin Works Best as a Long-Term Treatment
Long-term studies of tretinoin tend to show the most dramatic results, with people experiencing significant reductions in the appearance of fine wrinkling, coarse wrinkling, skin laxity and other signs of photoaging.
Tretinoin can help dark spots fade, allowing you to have a more even skin tone. It decreases the amount of melanin in your skin cells (Zasada, 2019). When used for discoloration, tretinoin is usually combined with other skin-lightening products, sometimes in the form of a chemical peel (Lawrence, 2021).
005% (low strength) tretinoin cream, which provides an optimal combination of effectiveness and tolerable side effects for most patients. If this cream isn't effective, your doctor might recommend switching to a stronger tretinoin cream.
Tretinoin is a more potent retinoid than retinol and will show results faster. While these active ingredients both combat signs of photoaging (aka wrinkles, rough skin, uneven skin tone, and enlarged pores), tretinoin-based products like Night Shift are more effective for fighting acne.
Tretinoin for acne scars
Tretinoin can also be used to decrease the appearance of acne scarring. Since tretinoin speeds up cell turnover on your skin, it can encourage new cell growth at the site of your scarring. Tretinoin in several forms has been tested successfully as an effective way to treat acne scars.
Tretinoin Does Not “Bleach” Your Skin
Contrary to popular belief, tretinoin is not a “bleaching agent” or medicine designed specifically to lighten your skin tone. While tretinoin can even out patches of hyperpigmentation and cause a mild change in your skin tone, it doesn't affect melanin synthesis.
Tretinoin gel, cream, or lotion requires a prescription because it's more powerful than retinol. Doctors prescribe tretinoin to treat skin conditions like: Acne. Psoriasis.
Yes. It's perfectly safe to use a moisturizer with tretinoin. In fact, tretinoin without moisturizer is generally not recommended. Many dermatologists advise their patients to moisturize while using it to reduce their chance of developing dry, peeling skin.
Use just a pea-sized portion.
This is enough for your face. Dab a bit from this portion onto your forehead, cheeks, and chin, then smooth it around. Use another pea-sized portion for your neck or chest if you need to apply in those areas, too.
First, the answer is yes, retinol can make wrinkles worse, especially when you first start using it. What is happening is a drying effect, and one can get epidermal sliding from separation from the dermis.
After 4-6 weeks, your skin will get used to tretinoin and will begin to be noticeably smoother and more even. A lot of the initial irritation will settle down and true “retinization” of your skin is in full force.
"You can use tretinoin or [over-the-counter] retinols forever."
Tretinoin usually comes in three strengths, 0.025%, 0.05%, and 0.1%. The stronger 0.05% and 0.1% creams are usually used to treat the appearance of wrinkles. The 0.1% cream may have better results for some people, but it can be harsher, so if your skin is sensitive, you may find the 0.05% cream is best for you.
Tretinoin is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. Tretinoin is classified as a "retinoid." (For more detail, see "How Tretinoin Works" section below).
Just make sure you choose products without synthetic fragrances to keep irritation at bay. When starting out, apply moisturizer directly after applying tretinoin to minimize potential irritation. As your skin adjusts, you can leave tretinoin on for about 20 minutes before following up with a moisturizer.
Dr. Mariwalla says coating your skin with Vaseline after applying retinoids or AHA acids would increase penetration of these ingredients, potentially leading to irritation.