LEP gene mutations that cause congenital leptin deficiency lead to an absence of leptin. As a result, the signaling that triggers feelings of satiety does not occur, leading to the excessive hunger and weight gain associated with this disorder.
Lipedema doesn't respond to diet and exercise like ordinary fat. Although there isn't a cure for lipedema, treatments can help you feel better.
The age of mortality was noted for 425 subjects with an average of 29.5 ± 16 years and ranged between 2 months and 67 years and significantly lower among males (28 ±16 years) compared with females (32 ±15 years) (F=6.5, p<0.01).
Genetics, weight loss and obesity: what the science tells us
For example, if you carry a particular variant in their MC4R gene, then you'll be predisposed to having increased levels of body fat. People with the MC4R gene are 8% more likely to be overweight and 12% more likely to be obese.
It's almost unknown for either men or women with Prader-Willi syndrome to have children. They're usually infertile because the testicles and ovaries do not develop normally. But sexual activity is usually possible, particularly if sex hormones are replaced.
Schaaf-Yang Syndrome (SYS) is a rare, paternally derived neurodevelopmental disorder that shares multiple clinical features with the genetically related Prader-Willi syndrome. It usually manifests at birth with muscular hypotonia in all and distal joint contractures in a majority of affected individuals.
Muscle helps keep up the rate at which you burn calories (metabolism). So as you lose weight, your metabolism declines, causing you to burn fewer calories than you did at your heavier weight. Your slower metabolism will slow your weight loss, even if you eat the same number of calories that helped you lose weight.
The Genetic Influence on Losing Weight
These genetic differences can impact metabolism, appetite regulation, and the distribution of body fat. For example, some individuals may have a genetic predisposition to a slower metabolic rate, making it harder for them to burn calories efficiently.
Certain diseases and medications
In some people, obesity can be traced to a medical cause, such as hypothyroidism, Cushing syndrome, Prader-Willi syndrome and other conditions. Medical problems, such as arthritis, also can lead to decreased activity, which may result in weight gain.
PWS is associated with a distinct behavioral phenotype that in some respects overlaps with autism spectrum disorder (ASD), a neurodevelopmental disorder characterized by restricted or repetitive behaviors (RRBs) and social-communication impairment.
“(Overeating) will actually rupture the wall of the stomach, and they become septic and die.” While drugs like Ozempic work by targeting receptors in the brain to tell people they're not hungry, these class of medications will not work on people with Prader-Willi syndrome.
Individuals with PWS are generally concrete thinkers; they often take things literally. Being a concrete thinker makes it difficult for individuals with PWS to understand metaphors, idioms, abstract concepts, and sarcasm. Being a concrete thinker can also make it difficult for individuals with PWS to understand humor.
Estrogen is one of the leading hormonal causes of thigh fat because it causes increased levels of fat cells which cause fat deposits to form in and around the thighs. Age can also be a contributing factor because aging results in a slower metabolism, which makes it more difficult to eliminate fat.
An analysis of 143 studies revealed that phentermine-topiramate and GLP-1 receptor agonists (like liraglutide and semaglutide) are among the most effective medications for reducing weight in people with obesity. The typical body weight reduction with these medications is 6% to 11%.
Acquired generalized lipodystrophy (AGL): Acquired generalized lipodystrophy (also called Lawrence syndrome) usually results in fat loss in your face, neck, arms and legs. Fat loss associated with AGL may occur rapidly over a few weeks or slowly over several months or even years.
The research of 488,376 people enrolled in the UK Biobank programme looked at the differences in health between those with and without a gene known as SMIM1. It found the few people missing the gene were 27 per cent more likely to have a body mass index classed as obese (BMI greater than 30) than those who had it.
Cortisol significantly impacts weight management. When cortisol levels surge, they trigger physiological responses that promote weight gain. These include increased fat storage, particularly in the abdominal area, and a slowed metabolism, making it harder to shed excess pounds.
The 30/30/30 is a weight loss method that involves eating 30 g of protein within the first 30 minutes of your day and following it with 30 minutes of light exercise. This morning routine is rooted in sound science, and it could be a good way to increase your capacity to burn fat while keeping lean muscle.
If you're asking yourself, “Why am I gaining weight when I barely eat,” several factors may be at play. Your body may be holding onto fat stores if your eating habits are inconsistent or restricted. Or, your weight gain may be the effect of a sedentary lifestyle, medical condition, or long-term stress.
CLIFAHDD is a congenital disorder characterized by congenital contractures of the limbs and face, resulting in characteristic facial features, hypotonia, and variable degrees of developmental delay. All reported cases have occurred de novo (summary by Chong et al., 2015). [
Shashi-Pena syndrome is a neurodevelopmental syndrome characterized by delayed psychomotor development, variable intellectual disability, hypotonia, facial dysmorphism, and some unusual features, including enlarged head circumference, glabellar nevus flammeus, and deep palmar creases.
Collapse Section. 48,XXXY syndrome is a chromosomal condition in boys and men that causes intellectual disability, developmental delays, physical differences, and an inability to father biological children (infertility). Its signs and symptoms vary among affected individuals.