What is the biggest indicator of lupus?

Author: Dennis Considine  |  Last update: Wednesday, November 26, 2025

The most common lupus symptoms (which are the same for men and women) are:
  • Extreme fatigue (feeling tired all the time)
  • Pain or swelling in the joints.
  • Swelling in the hands, feet, or around the eyes.
  • Headaches.
  • Low fevers.
  • Sensitivity to sunlight or fluorescent light.
  • Chest pain when breathing deeply.

What are the red flags for lupus?

Common lupus signs include:
  • Sores in your mouth or nose.
  • Hair loss visible to others.
  • Rash lasting for days to weeks in areas that have been exposed to the sun.
  • Swollen or stiff joints, which may be worse in the morning.
  • Chest pain with every deep breath, lasting more than 24 hours.

What confirms a lupus diagnosis?

Diagnosis
  • Complete blood count. This test measures the number of red blood cells, white blood cells and platelets as well as the amount of hemoglobin, a protein in red blood cells. ...
  • Erythrocyte sedimentation rate. ...
  • Kidney and liver assessment. ...
  • Urinalysis. ...
  • Antinuclear antibody (ANA) test.

What are the four criteria for lupus?

The ACR criteria include malar rash; discoid rash; photosensitivity (development of a rash after sun exposure); oral or nasal ulcers; arthritis of multiple joints; serositis: (inflammation of the lining around the lungs or heart); kidney disease indicated by protein or casts in the urine; neurological disorders such as ...

What is the number one symptom of lupus?

Fatigue or extreme tiredness

The most common symptom of lupus is fatigue, which means feeling extremely tired. Fatigue can affect a person's physical and mental health and quality of life. It can also make it hard for people with lupus to socially connect with others.

Lupus: Symptoms, Risk factors, Pathophysiology, Diagnosis and Treatments.

What is lupus belly?

Lupus can also cause other problems in the abdomen, including peritonitis (inflammation of the abdominal lining) and ascites (a build-up of fluids in the abdomen). Symptoms of peritonitis and ascites include: Abdominal pain and swelling. Nausea and vomiting.

What labs are elevated with lupus?

High levels of CRP in your blood may mean you have inflammation cause by lupus. ESR is another test for inflammation. It measures the amount of a protein that makes red blood cells clump together. ESR is usually high in people with active lupus.

What disease mimics lupus?

Other skin conditions that sometimes mimic the skin problems of lupus include melasma, psoriasis, eczema (atopic dermatitis), and facial seborrheic dermatitis. A dermatologist can diagnose these skin conditions. The symptoms of clinical depression can mimic lupus symptoms, and vice versa.

What organ does lupus affect the most?

Kidneys. Lupus can cause serious kidney damage, and kidney failure is one of the leading causes of death among people with lupus.

What not to tell someone with lupus?

What not to say
  • “I know how you feel”: Unless a person has had a serious condition, they do not know how it feels to have lupus. ...
  • “It could be worse”: Although people can say this with good intentions, it minimizes the seriousness of living with a chronic condition.

What are three triggers of lupus?

Exposure to certain factors in the environment – such as viral infections, sunlight, certain medications, and smoking – may trigger lupus. Immune and Inflammatory Influences.

What are the 11 markers for lupus?

The 11 criteria included were malar rash, discoid rash, photosensitivity, alopecia, Raynaud phenomenon, oral/nasal ulcers, arthritis (non-erosive arthritis involving 2 or more peripheral joints), serositis (pleurisy or pericarditis), renal disease (proteinuria greater than 500 mg daily or cellular RBC, granular, ...

What foods make lupus worse?

Foods that seem to trigger a flare vary greatly from person to person. So a food that causes problems for one person may have no effect on you. Some foods that have been said to make lupus worse include nightshade vegetables, and animal protein. Nightshade vegetables include potatoes, tomatoes, eggplant, and peppers.

What does lupus hair look like?

The most common type of lupus, systemic lupus erythematosus (SLE), can cause dry, coarse hair to develop along the hairline. These dry, coarse hairs break off easily, causing the sparse-looking hair known as lupus hair. Other types of hair loss also develop.

What is the cousin disease to lupus?

Sjogren's syndrome is a relatively common disease, although often under-diagnosed. Sjogren's syndrome can occur alone or in association with other autoimmune diseases, most commonly lupus and rheumatoid arthritis (RA).

What are lupus fingers?

Lupus Symptom: Raynaud's

Their fingers and toes become painful, numb, and tingly in response to cold temperatures or emotional stress. This happens when small blood vessels spasm and restrict blood flow to the area. During an attack, the fingers and toes may turn white or blue.

What is the hardest autoimmune disease to diagnose?

Vasculitis: Vasculitis involves inflammation of blood vessels, leading to various symptoms depending on the affected organs. The diagnosis often requires imaging studies and biopsies, making it one of the more challenging autoimmune diseases to identify.

What is the biggest symptom of lupus?

The most common lupus symptoms (which are the same for men and women) are:
  • Extreme fatigue (feeling tired all the time)
  • Pain or swelling in the joints.
  • Swelling in the hands, feet, or around the eyes.
  • Headaches.
  • Low fevers.
  • Sensitivity to sunlight or fluorescent light.
  • Chest pain when breathing deeply.

What is the gold standard test for lupus?

Anti-Nuclear Antibody (ANA) Test. Anti-nuclear antibodies (ANA) are autoantibodies to the nuclei of your cells. 98% of all people with systemic lupus have a positive ANA test, making it the most sensitive diagnostic test for confirming diagnosis of the disease.

What medications should you avoid if you have lupus?

Sulfa drugs, which make a person more sensitive to the sun, such as: Bactrim® and Septra® (trimethoprim-sulfamethoxazole); sulfisoxazole (Gantrisin®); tolbutamide (Orinase®); sulfasalazine (Azulfidine®); diuretics. Sun-sensitizing tetracycline drugs such as minocycline (Minocin®)

Does lupus cause weight gain?

Weight changes — Lupus can sometimes cause weight loss or weight gain. Weight loss may be unintentional and due to decreased appetite or problems with the digestive system (see 'Digestive system' below). It can also be a side effect of some medications used to treat lupus.

Where is a lupus headache?

People living with lupus may experience various types of headaches for different reasons. Some of these may include: Migraine: This is a type of moderate to severe headache that may feel like a throbbing pain on one side of the head.

Can lupus affect your eyes?

Lupus can affect many parts of your body, including the eyes. It can cause skin problems around the eye and dry eye — and side effects from lupus medicines can sometimes cause eye problems too. Although lupus doesn't usually cause serious vision loss, it can happen in rare cases.

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