What is niacinamide best combinations?

Author: Nico Kub  |  Last update: Thursday, September 18, 2025

Include vitamin C and niacinamide serum in your skincare routine and get an instant brightening effect and reduced dark spots in a few days. Both Niacinamide (vitamin B3) and Retinol (vitamin A) have expertise in tackling signs of ageing, acne, hyperpigmentation, and sun damage, making it a popular combination.

What should you not mix with niacinamide?

Niacinamide generally works well with most products, but it's best not to combine it with vitamin C (ascorbic acid) in the same routine as it can cause irritation. Additionally, avoid using it with strong exfoliants or retinoids in high concentrations to prevent skin sensitivity. For more, check out my Quora Profile.

What serum is best to layer with niacinamide?

Together, hyaluronic acid and niacinamide help boost hydration and soothe the skin, according to the Cleveland Clinic. Layering niacinamide and hyaluronic acid is beneficial for all skin types since everyone can afford more hydration in their routine.

What is the best pair with the ordinary niacinamide?

For smoother-looking skin, pair Retinaldehyde and Hyaluronic Acid. For clearer-looking skin, pair Salicylic Acid and Niacinamide 10% + Zinc 1%. For hydrated skin, pair Hyaluronic Acid and Niacinamide.

How to use niacinamide for best results?

After you cleanse apply Niacinamide on damp skin not to wet. Apply two drops of Niacinamide on to your hands, rub hands together slightly and then rub all over your face (particularly oiley areas and pores) followed by patting dry, wait 30 secs then seal in with your moisturiser.

Combining Active Ingredients: Retinol, Vitamin C, Niacinamide, & More! | Dr. Shereene Idriss

How can I make niacinamide more effective?

- Combine with Other Ingredients: Niacinamide can be combined with other active ingredients like hyaluronic acid, retinol, or vitamin C for enhanced benefits. However, it's essential to introduce new products slowly to avoid overwhelming the skin.

Do and don'ts niacinamide?

Don't use it with exfoliating ingredients: Niacinamide can increase skin sensitivity, so it's best to avoid using it with exfoliating ingredients such as salicylic acid and glycolic acid. Don't use it if you have an allergy: Niacinamide, like any other skincare ingredient, can cause allergic reactions in some people.

What compliments niacinamide?

Check out the list of ingredients that positively combine with niacinamide to benefit your skin effectively:
  • Niacinamide and vitamin C. ...
  • Niacinamide and retinol. ...
  • Niacinamide and salicylic acid. ...
  • Niacinamide and hyaluronic acid. ...
  • Niacinamide and Centella Asiatica.

What Cannot mix with the ordinary niacinamide?

Similar to retinol, niacinamide should not be used with acidic skincare ingredients like alpha hydroxy acids and beta hydroxy acids. Ordinary niacinamide combined with an acid can cause a bad chemical reaction of redness and flushing.

What skin care order with niacinamide?

In general, you'll want to apply niacinamide serum to a freshly washed face before using moisturizers or sunscreen. Plus, give each product time to absorb in the skin before applying another.

What goes first, retinol or niacinamide?

It is not unusual to find a combination of niacinamide and retinol in a single skincare product, but you can use niacinamide and retinol as separate steps in a consistent routine. If you're using separate products, it is recommended that you apply retinol first then move forward with niacinamide application.

Can I mix niacinamide with hyaluronic acid?

Hyaluronic acid and Niacinamide are a great pair as both are water-based treatments. When used together, always go with applying hyaluronic acid first, followed by Niacinamide. By following this, you would be able to attract plenty of hydration first.

What cancels out niacinamide?

DON'T MIX: AHA/BHA and niacinamide

Niacinamide is used to treat hyperpigmentation and reduce fine lines and wrinkles, while alpha hydroxy acids (AHAs) and beta hydroxy acids (BHAs) are chemical exfoliants. To understand why niacinamide shouldn't be mixed with AHAs and BHAs, you need to consider pH.

What reacts badly with niacinamide?

Niacinamide works well with other skincare ingredients, including retinol and hyaluronic acid. However, some ingredients, like vitamin C, may interact negatively with niacinamide. Therefore, it's recommended to use products containing these ingredients at different times of the day or on alternate days.

What products work well with niacinamide?

A gentle active ingredient that is very well tolerated by all skin types, niacinamide has the advantage of being compatible with the majority of cosmetic active ingredients, including the most sensitive substances such as retinol, peptides, hyaluronic acid, glycolic acid, lactic acid, salicylic acid and vitamin C.

What is best pair with the ordinary niacinamide?

Some Recommendations
  • For brighter-looking skin, pair Retinoids and Niacinamide. ...
  • For even-looking skin, pair Vitamin C derivatives with Glycolic Acid. ...
  • For smoother-looking skin, pair Retinaldehyde and Hyaluronic Acid. ...
  • For clearer-looking skin, pair Salicylic Acid and Niacinamide 10% + Zinc 1%.

Which moisturizer is best after niacinamide serum?

Consider pairing your niacinamide face serum with hyaluronic acid for an enhanced skincare regimen. Combining niacinamide with hyaluronic acid can brighten, hydrate, and plump up your skin. Apply niacinamide serum on a cleansed skin and let it absorb. After a few seconds, follow up with hyaluronic acid face serum.

What are the side effects of using niacinamide on your face?

Niacinamide is possibly safe when taken in doses up to 900-1500 mg daily. It might cause side effects such as stomach upset, gas, dizziness, headache, and rash. When applied to the skin: Niacinamide is possibly safe. Niacinamide cream might cause mild burning, itching, or redness.

Which serum goes best with niacinamide?

Niacinamide Combos We Love
  • Niacinamide + Vitamin C: The Radiance Enhancing Pair. ...
  • Niacinamide + Alpha Arbutin: The Skin Brightening Couple. ...
  • Niacinamide + Retinol. ...
  • Niacinamide + Salicylic Acid (BHA): The Pore Perfecting Couple. ...
  • Niacinamide + Ceramides: The Skin Restoring Duo.

How to make niacinamide work better?

Do: Pair with other active ingredients. Niacinamide can be paired with ingredients to address hyperpigmentation, such as lactic and glycolic acids to provide synergistic results, or can be combined with retinol to help boost tolerability and stimulate ceramide production, notes Dr. Garshick.

In what order should I use my ordinary products?

How To Build A Skincare Routine With The Ordinary Products
  1. Cleanser. Cleansing should always be the first step in your routine. ...
  2. Exfoliator. Once you've cleansed your skin in the morning, exfoliating should be next. ...
  3. Hydration serum. ...
  4. Eye serum. ...
  5. Antioxidant serum. ...
  6. Moisturiser. ...
  7. SPF. ...
  8. Cleanser.

Is 10% niacinamide too much?

Now, most people can tolerate niacinamide well even at 10% twice daily. But if you have a mysterious skin rash or unexplained irritation, it could be time to take a closer look at your niacinamide levels. One of the biggest issues of overdoing niacinamide isn't necessarily the one 10% product you may have.

What are the cons of niacinamide?

Safe but not totally for people with sensitive skin. As mentioned above, niacinamide seems to have an irritating effect when used with concentration formulas. Redness and itching are some of the common reactions. Although these are rare issues, they may still cause a great impact on someone's skin health.

How to know if niacinamide is working?

Niacinamide and hyaluronic acid

While you may not see any significant results during the first few weeks, there should be a notable difference by about 4 weeks. After 8 weeks, you should notice more hydrated, smoother, and toned skin.

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