What happens to skin when you stop using tretinoin?

Author: Bradley Flatley  |  Last update: Thursday, December 11, 2025

For many, tretinoin is highly effective at treating acne, but it's still possible to experience breakouts once you stop using it. Even while using tretinoin, you may continue to experience breakouts from time to time (we're looking at you, hormonal acne!), but that's also completely normal.

What will happen if I stop using tretinoin?

Tretinoin may reduce fine wrinkles, spotty discoloration, and rough feeling skin but does not cure them. It may take 3 to 4 months or up to 6 months before you notice improvement. If you stop using tretinoin, the improvement may gradually disappear.

Does skin go back to normal after tretinoin?

“The symptoms related to tretinoin purging typically involve acne breakouts, severe skin dryness and peeling, redness and irritation, but it is important to know that this phase is temporary and once it's over, the skin will generally begin to improve, and you will be able to see the positive effects.

Do you have to use tretinoin forever?

According to Dr. Mohta, to maintain the benefits you achieved over the past year, it is crucial to continue using tretinoin as part of your long-term skincare routine. You can safely use tretinoin long-term. Research has shown no negative effects even with 2-4 years of usage.

When is it time to quit tretinoin?

Signs you should stop using tretinoin

It's normal to experience some dryness, peeling, and irritation—maybe even some purging—as you adjust to using tretinoin. But if the side effects become severe or don't go away, it might be time to hit pause and give your skin a breather.

TRETINOIN - THE GREATEST LIE EVER TOLD!

What are the negative long-term effects of tretinoin?

What harm does Tretinoin do to the skin?
  • It makes the skin significantly more vulnerable to UV damage.
  • It causes contact irritant and photosensitivity reactions.
  • It damages the skin's barrier.
  • It increases chronic inflammation which in turn disrupts barrier function.
  • Its use in one study has been linked to premature death.

What does tretinoin purge look like?

Skin purging is common, but doesn't necessarily happen to everyone. In fact some people don't experience it at all. For those of us who do suffer from purging, it can look like: breaking out in pustules (pimples), the appearance of flaky, peeling skin, irritation and dry patches.

Is it OK to use tretinoin for years?

It's true that some people with persistent acne use tretinoin for years, but generally speaking, most stop once they have clearer skin or if they're no longer seeing results. Other people may continue to use tretinoin after their breakouts subside for the most part for maintenance therapy.

Should you take a break from tretinoin?

Skipping days gives your skin a rest. Once it starts feeling better, slowly work up to using it every day (or as directed by your healthcare provider). Don't stop using your treatment altogether. As your skin adjusts, dryness and peeling will taper off.

Does tretinoin cause weight gain?

If you experience any of the following symptoms, call your doctor immediately: fever; weight gain; swelling of the arms, hands, feet, ankles, or lower legs; shortness of breath; labored breathing; wheezing; chest pain; or cough.

Does your skin eventually get used to tretinoin?

AFTER 4 – 6 WEEKS

After 4-6 weeks, your skin will get used to Tretinoin and will begin to be noticeably smoother and more even.

Is tretinoin 3 times a week enough?

You should aim to use tretinoin every night, however, you must start slowly as your skin needs to get used to it. The first 2 weeks apply it 2 to 3 nights per week, after that try applying it every other day, and then if your skin can handle it, apply it every night.

Does tretinoin affect hair growth?

In conclusion, tretinoin has shown promise in promoting hair growth due to its ability to stimulate cell growth and enhance blood supply to hair follicles. While many have reported positive outcomes, it's essential to consult with a dermatologist to determine if it's the right option for you.

Is topical tretinoin bad for the liver?

Retinoids have been implicated in causing mild-to-moderate elevations in routine liver tests, but these elevations are usually asymptomatic and transient, resolving spontaneously even with continued therapy.

How long should I stay on tretinoin?

Tretinoin helps remove dead skin cells, allowing new cells to rise to the surface more efficiently. This stimulates collagen production and helps to reverse the effects of long-term sun exposure1. Tretinoin should be used for at least 6 months for maximum effect.

Should you give your skin a break from retinol?

It really is a case of less is more. So, if you'd still like to use other actives and exfoliants in your routine, make sure to do so on an alternate day to retinol and take a break if your skin starts to feel sensitive.

What happens if I suddenly stop using tretinoin?

One common consequence of discontinuing tretinoin is a temporary worsening of skin texture and appearance. Without the regular use of tretinoin, the benefits it provides may gradually fade away. Skin may become rougher, and the appearance of fine lines and wrinkles may become more pronounced.

What is the sandwich method for tretinoin?

Option one: The sandwich technique

After washing your face, apply a layer of moisturiser. Allow it to dry down for 5-10 minutes. Then, apply a pea-sized amount of tretinoin to your entire face. Allow this to dry down for 5-10 minutes.

Are tretinoin results permanent?

Tretinoin works best when used within a skin care program that includes protecting the treated skin from the sun. However, it does not completely or permanently erase these skin problems or greatly improve more obvious changes in the skin, such as deep wrinkles caused by the sun or the natural aging process.

What is the downside of tretinoin?

Topical tretinoin can cause your skin to become dry, red, swollen, blistered, or flaky. It may also cause your skin to itch, be painful, or feel like it is burning. Stop using topical tretinoin and call your healthcare provider if these symptoms become worse or do not go away.

Does tretinoin thicken or thin skin?

Topical tretinoin stimulates epidermal proliferation and differentiation by upregulating heparin binding epidermal growth factor (HB-EGF), which causes increased exfoliation and thickening of the epidermis.

Does tretinoin destroy the skin barrier?

Prescription retinoids like tretinoin are extremely powerful. This means you must use them properly under the guidance of your dermatologist or doctor — or you could risk some unpleasant reactions like burning skin or a damaged skin barrier.

What are the tretinoin uglies?

Vitamin A can be unstable as an ingredient, and this can mean your skin will become more sensitive. There is often an initial phase when using retinoids for the first time, known by many as the 'retinoid uglies'. Essentially, your skin can see a decline before improvement during an adjustment period.

What are the results of tretinoin 3 months?

The time it takes to start fading hyperpigmentation varies depending on severity and whether you're using Tretinoin alongside Hydroquinone. Noticeable improvements in skin tone may start after as little as 6-8 weeks or as much as 3-6 months of regular use.

What moisturizer goes well with tretinoin?

Three inexpensive moisturizers that our physicians love are Vanicream Daily Facial Lotion with Hyaluronic Acid, Neutrogena Hydroboost Gel, and The Ordinary Hyaluronic Acid Serum. All three of these are affordable, non-comedogenic,and blend well with tretinoin.

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