What happens if you use too much hydrocortisone cream?

Author: Earlene Bauch  |  Last update: Tuesday, April 22, 2025

Using hydrocortisone for a long time without stopping can mean some of the medicine gets into your blood. If this happens, there's a very small chance it can cause serious side effects, such as adrenal gland problems, high blood sugar (hyperglycaemia), or problems with your eyesight.

What does overuse of hydrocortisone look like?

Burning, stinging, and bright red skin are the typical features of topical steroid overuse and withdrawal. The signs and symptoms occur within days to weeks after TCS discontinuation.

What damage can hydrocortisone do?

Common hydrocortisone side effects include burning, irritation, and dry skin or itching. These side effects may go away on their own, and they are usually mild. Serious side effects include high blood glucose, Cushing's syndrome, and TSW.

How many times a day can you use hydrocortisone ointment?

Most people need to use hydrocortisone cream or ointment once or twice a day. If you use it twice a day, try to leave a gap of 8 to 12 hours before putting on any more. The amount of cream or ointment you need to use is sometimes measured in fingertip units.

Can hydrocortisone make a rash worse?

Skin infections can become worse when this medication is used. Tell your doctor promptly if redness, swelling, or irritation does not improve.

What happens if you use too much steroid cream? - Dr. Urmila Nischal

Does hydrocortisone heal or just stop itching?

Hydrocortisone is a steroid (corticosteroid) medicine. It works by calming down your body's immune response to reduce pain, itching and swelling (inflammation). It can also be used as hormone replacement for people who do not have enough of the natural stress hormone, cortisol.

What are the symptoms of taking too much hydrocortisone?

Check with your doctor right away if you have darkening of the skin, diarrhea, dizziness, fainting, joint pain, loss of appetite, mental depression, nausea, skin rash, unusual tiredness or weakness, or vomiting.

How do I know if I used too much hydrocortisone cream?

Stop using hydrocortisone and tell a doctor or call 111 straight away if: your skin becomes swollen, yellow fluid is weeping from your skin or your skin becomes redder (redness may be less obvious on brown or black skin) – these are signs of a new skin infection or an existing one getting worse.

Where should you not apply hydrocortisone?

Unless otherwise directed by your doctor, do not apply this medicine to open wounds, burns, or broken or inflamed skin. This medicine should only be used for problems being treated by your doctor. Check with your doctor before using it for other problems, especially if you think that an infection may be present.

Can skin recover from steroid cream?

How long does it take to wean off steroid cream? Talk with your doctor about how to stop your topical steroid use. After you stop their use, it can take anywhere from a couple of days to several months to see improvement in your skin. For a small number of people, this can take several years.

What are the cons of hydrocortisone cream?

Side Effects
  • Blistering, burning, crusting, dryness, or flaking of the skin.
  • irritation.
  • itching, scaling, severe redness, soreness, or swelling of the skin.
  • redness and scaling around the mouth.

What does a steroid rash look like?

After several weeks of applying a topical steroid to the mid-forehead, eyelids, cheeks or chin, the affected area becomes red. Small bumps (papules) and pustules appear. These may be scaly. The reddened areas feel burning hot and itchy.

What happens if you use too much steroid cream?

If potent or very potent topical corticosteroids are used for a long time or over a large area, there's a risk of the medicine being absorbed into the bloodstream and causing internal side effects, such as: decreased growth in children. Cushing's syndrome.

What does steroid damaged skin look like?

Skin atrophy typically presents as thin, shiny skin. Once it develops, further topical steroid side effects may occur, such as telangiectasia, easy bruising, purpura, and striae.

Can hydrocortisone harm you?

You're more likely to get serious side effects if you take high doses of hydrocortisone over many months. Speak to a doctor if you get a puffy, rounded face and weight gain in your upper back or belly. This happens gradually and can be a sign of Cushing's syndrome.

Do you rub hydrocortisone all the way in?

To use hydrocortisone topical, apply a small amount of ointment, cream, solution, spray, or lotion to cover the affected area of skin with a thin even film and rub it in gently. This medication is only for use on the skin. Do not let hydrocortisone topical get into your eyes or mouth and do not swallow it.

What can you not mix with hydrocortisone?

The following nonprescription or herbal products may interact with hydrocortisone: aspirin, ibuprofen (Advil, Motrin), and naproxen (Aleve). Be sure to let your doctor and pharmacist know that you are taking these medications before you start taking hydrocortisone.

Why hydrocortisone Cannot be taken at night?

Treatment with conventional thrice-daily hydrocortisone is associated with exposure to high cortisol levels in the late afternoon and evening, which may lead to the development of increased cardiovascular risk (10, 12, 27, 28), disturbance of sleep pattern, and cognitive dysfunction (14, 29, 30, 31).

What are three signs of contact dermatitis?

Signs and symptoms of contact dermatitis vary widely and may include:
  • An itchy rash.
  • Leathery patches that are darker than usual (hyperpigmented), typically on brown or Black skin.
  • Dry, cracked, scaly skin, typically on white skin.
  • Bumps and blisters, sometimes with oozing and crusting.
  • Swelling, burning or tenderness.

How long does it take for hydrocortisone cream to absorb into skin?

Doctors recommend waiting about 15 minutes between applying a topical steroid and applying the moisturizing product. This allows the steroid to be absorbed properly. According to current knowledge, it doesn't matter which order you apply them in.

Can you put moisturizer over hydrocortisone?

When a moisturizer and a topical steroid are applied together, which should be applied first? Apply the moisturizer with a larger application area first, and then apply the topical steroid to only areas affected with disease, such as eczema.

Can hydrocortisone damage your skin?

The skin on your face is delicate, and if hydrocortisone damages it, it's particularly noticeable. Some common skin problems that affect the face, such as impetigo, rosacea and acne, can be made worse by hydrocortisone. If your doctor has prescribed hydrocortisone for your face, follow their instructions carefully.

What are the positive effects of hydrocortisone?

Hydrocodone is primarily used to treat severe chronic pain that requires opioid analgesia and is not effectively treated by nonopioid alternatives. Hydrocodone is used in combination formulations to treat nonproductive cough in adults and has antitussive properties.

How much hydrocortisone is too much?

If you take too much

Taking 1 or 2 extra hydrocortisone tablets once is unlikely to harm you. If you're worried, talk to your doctor or pharmacist. If you take too much hydrocortisone for more than a few days, it could harm your health.

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