The clinical appearance of acneiform exanthema occurring during treatment with vitamin B6 or B12 consists of loosely disseminated small papules or papulopustules on the face (especially on the forehead and chin), on the upper parts of the back and chest and spreading to the upper arm.
Supplementation with high doses of vitamins B6 and B12 have been reported to worsen existing acne, with more reports in females than males [18-20]. Supplementation with high-dose vitamin B12 (more than 5-10mg per week) or use for long periods has been described as contributing to acne outbreaks [19,21].
The lesions usually tend to resolve two to three weeks after the cessation of vitamin B12, and can flare up after its reintroduction [9], which has not been necessary to date for our patient.
Vitamin B6 had been discovered as an anti-dermatitis factor, and has long been believed to be essential for skin development and maintenance. On the basis of such information, vitamin B6 has been often incorporated into various supplements and skin creams for skin care and maintenance.
In adults, vitamin B6 deficiency can cause inflammation of the skin (dermatitis) and a red, greasy, scaly rash. The hands and feet may feel numb and prickling—like pins and needles. The tongue may become sore and red, and cracks may form in the corners of the mouth.
In most cases, vitamin B6 deficiency can be overcome within a few weeks to a few months. However, people with severe vitamin B6 deficiency or an underlying medical condition may need to take a vitamin B6 supplement for a more extended period.
High intakes of vitamin B6 from food sources have not been reported to cause adverse effects [1]. However, chronic administration of 1–6 g oral pyridoxine per day for 12–40 months can cause severe and progressive sensory neuropathy characterized by ataxia (loss of control of bodily movements) [10,30-33].
Research shows B6 supplementation regulated hormones and reduced premenstrual acne over two months. Additionally, low levels of B-vitamins generally are linked to skin issues like acne, dermatitis, rashes and sensitivity. Optimal intake can prevent deficiency-associated skin disorders.
High-dose vitamins B6 and B12 have also been linked to rosacea fulminans, a condition that looks like acne. Rosacea is marked by large red bumps and pustules that typically appear on the nose, chin, and/or cheeks.
Vitamin B Family:
B5 (Pantothenic Acid): Reduces sebum production and hormonal acne. B1 (Thiamine): Boosts immunity, helping prevent stress-related acne.
Oral Medication
This can include: Antibiotics — Oral antibiotics work to treat acne by killing off the bacteria that are irritating your skin and triggering breakouts. Hormone Supplements — Oral contraceptives, like birth control pills, help to level out your hormonal balances to improve acne breakouts.
In some people, vitamin B6 might cause nausea, stomach pain, loss of appetite, headache, and other side effects. Vitamin B6 is possibly unsafe when taken in doses of 500 mg or more daily. High doses of vitamin B6, especially 1000 mg or more daily, might cause brain and nerve problems.
A number of dietary supplements have also been linked to acne, including those containing vitamins B6/B12, iodine, and whey, as well as "muscle building supplements" that may be contaminated with anabolic-androgenic steroids (AAS).
The deficiency of vitamin B12 can cause specific skin manifestations, such as hyperpigmentation, vitiligo, angular stomatitis, and hair and nail changes [1].
When the lymph system is blocked and fluid is building then your skin can be what suffers. As the toxins are stuck under the skin around the neck and jawline it can cause large breakouts of acne.
People with acne often have low levels of antioxidants like vitamin E and selenium, which almonds, peanuts, and Brazil nuts have a lot of. These nutrients protect cells from damage and infections. There's no clear proof that antioxidants will clear up acne, but they are good for your body in other ways.
While it's true that you might experience a temporary breakout when you first start taking probiotics, this is often a sign of your body adjusting to the new bacteria. This initial purging phase is usually short-lived and can be considered a positive sign that your gut microbiome is rebalancing.
If you take products that contain vitamin B6, be aware of symptoms of peripheral neuropathy, such as tingling, burning, or numbness. If you experience any of these symptoms, you should stop taking the product and seek medical advice.
Patients typically experience symptoms of peripheral neuropathy, dermatoses, photosensitivity, dizziness, and nausea with long-term intake of dosages above 250 mg/day. Additional morbidity would include ataxia and dysesthesias.
Medicines that reduce levels of B6 in the body.
Cycloserine (Seromycin), used to treat tuberculosis. Hydralazine (Apresoline), used to treat high blood pressure. Isoniazid, used to treat tuberculosis. Penicillamine, used to treat RA.
Combining Vitamin B6 and Magnesium offers numerous health benefits, particularly in managing stress and fatigue. These nutrients can improve overall health and well-being, making a noticeable difference in dealing with daily stressors or chronic fatigue.