What Cannot be mixed with glycolic acid?

Author: Ervin Cormier I  |  Last update: Friday, September 26, 2025

What NOT to mix with Glycolic Acid. Retinol, other AHAs/BHAs, Vitamin C: Using these ingredients alongside Glycolic Acid in the same routine could irritate the skin. However, alternating them between your morning and evening skincare routine means that you can enjoy the benefits without the risk of damaging your skin.

What can glycolic acid not mix with?

Combining glycolic acid and lactic acid can be quite potent and is generally not recommended due to the increased risk of irritation. Both acids are effective exfoliants, and using them together can over-exfoliate the skin.

What clashes with glycolic acid?

Retinoids and Glycolic Acid

Retinoids (including retinol) are fantastic for boosting cell turnover and fighting aging. However, pairing them with glycolic acid is like inviting two energetic party crashers into a small room—they can overwhelm your skin.

What cancels out glycolic acid?

Glycolic acid and niacinamide.

Indeed, niacinamide used with AHA's like glycolic acid and lactic acid has no effect and can even cause redness. Since niacinamide has a pH of about 5-7, it can actually increase the lower pH of glycolic acid, which is about 3-4, and negate its properties.

Can I mix glycolic acid with niacinamide?

If you've ever questioned, “Can I use niacinamide with glycolic acid in my skincare regimen,” don't worry—they most definitely can. Both of these can be used in a single skincare routine. You have to choose the right products from the top brands and follow a healthy skin routine.

Why I No Longer Use GLYCOLIC ACID - Glycolic Acid Explored

What does glycolic acid pair well with?

Glycolic acid and vitamin C: This combination can increase collagen production and smooth skin, but it's best to stagger application to keep skin from getting irritated.

What should you never mix niacinamide with?

DON'T MIX: AHA/BHA and niacinamide

Niacinamide is used to treat hyperpigmentation and reduce fine lines and wrinkles, while alpha hydroxy acids (AHAs) and beta hydroxy acids (BHAs) are chemical exfoliants. To understand why niacinamide shouldn't be mixed with AHAs and BHAs, you need to consider pH.

What should not be layered with glycolic acid?

Combining glycolic acid and lactic acid can be quite potent and is generally not recommended due to the increased risk of irritation. Both acids are effective exfoliants, and using them together can over-exfoliate the skin.

What serum works best with glycolic acid?

Best Glycolic Acid Serums
  • Dr. ...
  • Minimalist 10% AHA BHA Exfoliating Serum.
  • L'Oreal Paris Glycolic Bright Face Serum.
  • Himalaya Dark Spot Clearing Turmeric Serum.
  • Dot & Key Watermelon 10% Glycolic Serum.
  • Rejusure 5% Glycolic Acid Facial Serum.
  • Lakme Glycolic Illuminate Face Serum.
  • Dermtribe 10% Glycolic Acid Face Serum.

Which serums cannot be used together?

Skincare ingredients not to mix
  • Retinoids or retinol and benzoyl peroxide. ...
  • Retinoids or retinol and vitamin C. ...
  • Retinoids or retinol and salicylic acid. ...
  • Retinoid or retinol and AHAs/BHAs. ...
  • Vitamin C and AHAs/BHAs. ...
  • Vitamin C and benzoyl peroxide. ...
  • Niacinamide and AHAs / BHAs. ...
  • Benzoyl peroxide and hydroquinone.

What happens if you use too much glycolic acid on face?

However, as with all chemical exfoliants, using glycolic acid too frequently, at too high a concentration, or incorrectly can result in skin irritation or damage.

What is the best peptide serum for face?

Our Top Peptide Serums
  • Best for Inflammation: Eighth Day Regenerative Serum, $195.
  • Best for Dullness: Best for Dullness: Drunk Elephant Protini Powerpeptide Resurf Serum, $82.
  • Best Budget: The Ordinary Multi-Peptide + Copper Peptides 1% Serum, $32.
  • Best Eye Cream: Dermalogica Phyto Nature Lifting Eye Cream, $127.

What can I alternate with glycolic acid?

Otherwise, a good way to incorporate retinol into your beauty routine in addition to glycolic acid would be to alternate them every other night: one night using retinol, another night using a no-rinse exfoliating treatment followed by a moisturizing cream.

Can I mix retinol and glycolic acid?

Yes, you can! With strategic use, the combined benefits of glycolic acid and retinol can help you attain a healthier, radiant complexion. Need help with your skincare routine? Take help from the L'Oréal Paris Skin Genius tool to get a customized skincare routine and take care of your skin like a pro.

What ingredients neutralize glycolic acid?

AHAs include glycolic acid from sugar cane, lactic acid from milk, and citric acid from citrus fruits. To cease its action during a peel, glycolic acid necessitates a neutralizing agent, such as sodium bicarbonate and water.

Is hyaluronic acid OK with glycolic acid?

Absolutely! In fact, these two ingredients are a skincare dream team. Glycolic acid exfoliates and renews your skin, but it can sometimes cause dryness or irritation. That's where hyaluronic acid comes in—it replenishes moisture and soothes your skin after exfoliation.

What pairs well with glycolic acid?

To double down on anti-aging benefits, pair glycolic acid with either lactic acid or malic acid, both of which unblock pores so that exfoliation is more effective.

What products are not to use with glycolic acid?

Retinol, other AHAs/BHAs, Vitamin C: Using these ingredients alongside Glycolic Acid in the same routine could irritate the skin. However, alternating them between your morning and evening skincare routine means that you can enjoy the benefits without the risk of damaging your skin.

Which serum should not be used with glycolic acid?

Niacinamide. Niacinamide is a form of vitamin B3 and has become a well-loved skin care ingredient, as it has soothing properties, helps reduce redness and supports overall collagen production. Glycolic acid's potency can potentially dry out the skin, which is where niacinamide comes in.

Can I use glycolic with niacinamide?

As glycolic acid has a low molecular weight, it can irritate your skin. Those with sensitive skin might initially experience dry, flaky skin and mild redness. But when you layer it with niacinamide, it can lessen these possible side effects by strengthening your skin's barrier.

What is best to apply after glycolic acid?

Hydrate and moisturise: Use hydrating products like serums or moisturisers after using glycolic acid. These aid in rehydrating and nourishing the skin. Look for products that contain hydrating ingredients like hyaluronic acid, ceramides, or natural oils to help maintain a healthy skin barrier.

What happens if I use glycolic acid daily?

It is OK to use 1-2% containing glycolic acid face wash or ointments daily. The creams have a higher glycolic acid content (10% and above) and must only be used once or twice a week to avoid skin irritation. The creams with a concentration above 15% may need to be kept only for a few minutes and then wiped off.

What reacts badly with niacinamide?

Niacinamide works well with other skincare ingredients, including retinol and hyaluronic acid. However, some ingredients, like vitamin C, may interact negatively with niacinamide. Therefore, it's recommended to use products containing these ingredients at different times of the day or on alternate days.

Which serums should not be mixed?

6 Skin-Care Ingredient Combinations That Don't Mix
  • Skin products may work well for you on their own, but do they all work in combination? ...
  • Retinoid or Retinol and Alpha Hydroxy Acid. ...
  • Retinoid or Retinol and Benzoyl Peroxide. ...
  • Retinoid or Retinol and Vitamin C. ...
  • Retinoid or Retinol and Salicylic Acid.

Can I use vitamin C and glycolic acid together?

CAN YOU USE BOTH GLYCOLIC ACID AND VITAMIN C? While both glycolic acid and vitamin C are skincare superstars, using them together requires a bit of caution, and it's generally not recommended to use them at the same time. If you're not sure about your routine, it's best to avoid using them in unison.

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